scholarly journals Differential Epigenetic Modifications of Histones at the Myosin Heavy Chain Genes in Fast and Slow Skeletal Muscle Fibers and in Response to Muscle Unloading

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Clay E Pandorf ◽  
Fadia Haddad ◽  
Kenneth M Baldwin
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Epigenetic Modifications ◽  
Slow Skeletal Muscle ◽  
Skeletal Muscle Fibers ◽  
Myosin Heavy Chain Genes ◽  
Muscle Unloading

Effects of Creatine Supplementation During Resistance Training on Myosin Heavy Chain (MHC) Expression in Rat Skeletal Muscle Fibers

2010 ◽  
Vol 24 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Andreo F Aguiar ◽  
Danilo H Aguiar ◽  
Alan DS Felisberto ◽  
Fernanda R Carani ◽  
Rachel C Milanezi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Creatine Supplementation ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Fibers

scholarly journals Innervation regulates myosin heavy chain isoform expression in developing skeletal muscle fibers

1996 ◽  
Vol 58 (1-2) ◽  
pp. 115-127 ◽  
Author(s):  
Bruno Lefeuvre ◽  
Fe´lix Crossin ◽  
Josiane Fontaine-Pe´rus ◽  
Everett Bandman ◽  
Marie-France Gardahaut
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Myosin Heavy Chain Isoform ◽  
Skeletal Muscle Fibers ◽  
Isoform Expression

Single-fiber myosin heavy chain polymorphism: how many patterns and what proportions?

2003 ◽  
Vol 285 (3) ◽  
pp. R570-R580 ◽  
Author(s):  
Vincent J. Caiozzo ◽  
Michael J. Baker ◽  
Karen Huang ◽  
Harvey Chou ◽  
Ya Zhen Wu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Myosin Heavy Chain Isoforms ◽  
Single Fiber ◽  
Myosin Heavy Chain Isoform ◽  
Skeletal Muscle Fibers ◽  
Velocity Relationship ◽  
Force Velocity

Previous studies have reported the existence of skeletal muscle fibers that coexpress multiple myosin heavy chain isoforms. These surveys have usually been limited to studying the polymorphic profiles of skeletal muscle fibers from a limited number of muscles (i.e., usually <4). Additionally, few studies have considered the functional implications of polymorphism. Hence, the primary objective of this study was to survey a relatively large number of rat skeletal muscle/muscle regions and muscle fibers ( n≈ 5,000) to test the hypothesis that polymorphic fibers represent a larger fraction of the total pool of fibers than do so-called monomorphic fibers, which express only one myosin heavy chain isoform. Additionally, we used Hill's statistical model of the force-velocity relationship to differentiate the functional consequences of single-fiber myosin heavy chain isoform distributions found in these muscles. The results demonstrate that most muscles and regions of rodent skeletal muscles contain large proportions of polymorphic fibers, with the exception of muscles such as the slow soleus muscle and white regions of fast muscles. Several muscles were also found to have polymorphic profiles that are not consistent with the I↔IIA↔IIX↔IIB scheme of muscle plasticity. For instance, it was found that the diaphragm muscle normally contains I/IIX fibers. Functionally, the high degree of polymorphism may 1) represent a strategy for producing a spectrum of contractile properties that far exceeds that simply defined by the presence of four myosin heavy chain isoforms and 2) result in relatively small differences in function as defined by the force-velocity relationship.

Myosin heavy chain expression within the tapered ends of skeletal muscle fibers

1995 ◽  
Vol 242 (4) ◽  
pp. 462-470 ◽  
Author(s):  
Benjamin W. C. Rosser ◽  
Donna M. Waldbillig ◽  
Stacey D. Lovo ◽  
Jacalyn D. Armstrong ◽  
Everett Bandman
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Skeletal Muscle Fibers

scholarly journals Type 2X-myosin heavy chain is coded by a muscle fiber type-specific and developmentally regulated gene.

1993 ◽  
Vol 123 (4) ◽  
pp. 823-835 ◽  
Author(s):  
C DeNardi ◽  
S Ausoni ◽  
P Moretti ◽  
L Gorza ◽  
M Velleca ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Development ◽  
Fiber Type ◽  
Muscle Fibers ◽  
Hindlimb Muscles ◽  
Isolation And Characterization ◽  
Skeletal Muscle Fibers ◽  
Myhc Isoforms

We have previously reported the identification of a distinct myosin heavy chain (MyHC) isoform in a major subpopulation of rat skeletal muscle fibers, referred to as 2X fibers (Schiaffino, S., L. Gorza, S. Sartore, L. Saggin, M. Vianello, K. Gundersen, and T. Lømo. 1989. J. Muscle Res. Cell Motil. 10:197-205). However, it was not known whether 2X-MyHC is the product of posttranslational modification of other MyHCs or is coded by a distinct mRNA. We report here the isolation and characterization of cDNAs coding a MyHC isoform that is expressed in type 2X skeletal muscle fibers. 2X-MyHC transcripts differ from other MyHC transcripts in their restriction map and 3' end sequence and are thus derived from a distinct gene. In situ hybridization analyses show that 2X-MyHC transcripts are expressed at high levels in the diaphragm and fast hindlimb muscles and can be coexpressed either with 2B- or 2A-MyHC transcripts in a number of fibers. At the single fiber level the distribution of each MyHC mRNA closely matches that of the corresponding protein, determined by specific antibodies on serial sections. In hindlimb muscles 2X-, 2A-, and 2B-MyHC transcripts are first detected by postnatal day 2-5 and display from the earliest stages a distinct pattern of distribution in different muscles and different fibers. The emergence of type 2 MyHC isoforms thus defines a distinct neonatal phase of fiber type differentiation during muscle development. The functional significance of MyHC isoforms is discussed with particular reference to the velocity of shortening of skeletal muscle fibers.

scholarly journals Fluorescence polarization of skeletal muscle fibers labeled with rhodamine isomers on the myosin heavy chain

1996 ◽  
Vol 71 (6) ◽  
pp. 3330-3343 ◽  
Author(s):  
C.L. Berger ◽  
J.S. Craik ◽  
D.R. Trentham ◽  
J.E. Corrie ◽  
Y.E. Goldman
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Fluorescence Polarization ◽  
Muscle Fibers ◽  
Skeletal Muscle Fibers

Evidence for three adult fast myosin heavy chain isoforms in type II skeletal muscle fibers in pigs.

1998 ◽  
Vol 76 (6) ◽  
pp. 1584 ◽  
Author(s):  
L Lefaucheur ◽  
R K Hoffman ◽  
D E Gerrard ◽  
C S Okamura ◽  
N Rubinstein ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Myosin Heavy Chain Isoforms ◽  
Type Ii ◽  
Fast Myosin ◽  
Skeletal Muscle Fibers ◽  
Fast Myosin Heavy Chain

scholarly journals Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle Fibers

2001 ◽  
Vol 276 (49) ◽  
pp. 45902-45908 ◽  
Author(s):  
Stefan Weiss ◽  
Rosetta Rossi ◽  
Maria-Antonietta Pellegrino ◽  
Roberto Bottinelli ◽  
Michael A. Geeves
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibers ◽  
Myosin Heavy Chain Isoforms ◽  
Release Rates ◽  
Shortening Velocity ◽  
Skeletal Muscle Fibers ◽  
Adp Release
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