scholarly journals EFFECTS OF FATTY ACIDS ON PRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) BY SKELETAL MUSCLE CELLS

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Renato Tadeu Nachbar ◽  
Augusto Ducati Luchessi ◽  
Tavane David Cambiaghi ◽  
Rafael Herling Lambertucci ◽  
Sandro Massao Hirabara ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Oxygen Species

Intracellular generation of reactive oxygen species by contracting skeletal muscle cells

2005 ◽  
Vol 39 (5) ◽  
pp. 651-657 ◽  
Author(s):  
Francis McArdle ◽  
David M. Pattwell ◽  
Aphrodite Vasilaki ◽  
Anne McArdle ◽  
Malcolm J. Jackson
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Oxygen Species

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

2011 ◽  
Vol 410 (3) ◽  
pp. 665-670 ◽  
Author(s):  
Claudio Cabello-Verrugio ◽  
María José Acuña ◽  
María Gabriela Morales ◽  
Alvaro Becerra ◽  
Felipe Simon ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Angiotensin Ii ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Oxygen Species ◽  
Fibrotic Response

Reactive oxygen species are important mediators of taurine release from skeletal muscle cells

2003 ◽  
Vol 284 (6) ◽  
pp. C1362-C1373 ◽  
Author(s):  
Niels Ørtenblad ◽  
Jette Feveile Young ◽  
Niels Oksbjerg ◽  
Jacob Holm Nielsen ◽  
Ian Henry Lambert
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Reactive Oxygen ◽  
Anion Channel ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Cell Swelling ◽  
Oxygen Species ◽  
Taurine Release ◽  
Taurine Efflux

The present study illustrates elements of the signal cascades involved in the activation of taurine efflux pathways in myotubes derived from skeletal muscle cells. Exposing primary skeletal muscle cells, loaded with 14C-taurine, to 1) hypotonic media, 2) the phospholipase A2 (PLA2) activator melittin, 3) anoxia, or 4) lysophosphatidyl choline (LPC) causes an increase in 14C-taurine release and a concomitant production of reactive oxygen species (ROS). The antioxidants butulated hydroxy toluene and vitamin E inhibit the taurine efflux after cell swelling, anoxia, and addition of LPC. The muscle cells possess two separate taurine efflux pathways, i.e., a swelling- and melittin-induced pathway that requires 5-lipoxygenase activity for activation and a LPC-induced pathway. The two pathways are distinguished by their opposing sensitivity toward the anion channel blocker DIDS and cholesterol. These data provide evidence for PLA2 products and ROS as key mediators of the signal cascade leading to taurine efflux in muscle.

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