scholarly journals Granulovacuolar degeneration bodies of Alzheimer's disease resemble late‐stage autophagic organelles

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Kristen E Funk ◽  
Robert E Mrak ◽  
Jeff Kuret
2017 ◽  
Vol 58 (4) ◽  
pp. 1027-1033 ◽  
Author(s):  
Sandra L. Siedlak ◽  
Yinfei Jiang ◽  
Mikayla L. Huntley ◽  
Luwen Wang ◽  
Ju Gao ◽  
...  

1997 ◽  
Vol 3 (2) ◽  
pp. 195-198 ◽  
Author(s):  
SANDRA M. BOLOGNA ◽  
CAMERON J. CAMP

Some persons with Alzheimer's disease (AD) lose the ability to recognize themselves, as when they cannot overtly recognize their reflection in a mirror. There is evidence, however, that covert or unconscious self-recognition might be displayed in such individuals. In this study, 3 persons with AD lacking the ability to overtly self-recognize demonstrated multiple instances of unconscious or covert self-recognition. A variety of interventions, inspired by research with prosopagnosics, was implemented to remediate this loss. Interventions enabled all participants to exhibit overt self-recognition, though each did so with the aid of a different intervention. In addition, successful overt self-recognition required a verbal probe and was entirely intervention-dependent: When the intervention was removed, overt self-recognition was lost. Results support a dissociation between explicit–declarative versus implicit–nondeclarative memory systems, and extends this dissociation into the realm of self-recognition in AD. (JINS, 1997, 3, 195–198.)


2002 ◽  
Vol 103 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Allal Boutajangout ◽  
Karelle Leroy ◽  
Authelet M. ◽  
Brian Anderton ◽  
Jean-Pierre Brion ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Tadashi Kanamori ◽  
Yoshiyuki Kaneko ◽  
Kouju Yamada ◽  
Masahiro Suzuki

Pica in Alzheimer's disease (AD) makes it difficult for caregivers to provide care. However, few effective medications have been reported for pica in AD. We report a case of AD with pica that was successfully improved by trazodone and fluvoxamine. An 80-year-old woman with AD was admitted to our hospital due to aggravated pica, including eating weeds in the facility's garden and eating a dishwashing sponge. Her pica was accompanied by oral tendency, prosopagnosia, and placidity. She took rivastigmine and memantine, but these were ineffective for her pica. She was given olanzapine and perospirone, but both were discontinued due to over-sedation and severe extrapyramidal symptoms, respectively. We then administered trazodone and fluvoxamine, both of which have demonstrated effectiveness for pica in frontotemporal dementia (FTD). Her pica behaviors then disappeared without daytime sleepiness. In this case, pica with oral tendency, which was accompanied by prosopagnosia and placidity, may be interpreted as a partial symptom of Klüver–Bucy syndrome (KBS). KBS is often seen in FTD, but also occurs in late-stage AD. Our case together with previous reports showing that trazodone and fluvoxamine were effective for pica in FTD suggest that the same common drug therapy may be successful in pica with oral tendency, regardless of the subtype of dementia.


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