Covert versus overt self-recognition in late stage Alzheimer's disease

1997 ◽  
Vol 3 (2) ◽  
pp. 195-198 ◽  
Author(s):  
SANDRA M. BOLOGNA ◽  
CAMERON J. CAMP
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Stage ◽  
Memory Systems ◽  
Self Recognition ◽  
Nondeclarative Memory

Some persons with Alzheimer's disease (AD) lose the ability to recognize themselves, as when they cannot overtly recognize their reflection in a mirror. There is evidence, however, that covert or unconscious self-recognition might be displayed in such individuals. In this study, 3 persons with AD lacking the ability to overtly self-recognize demonstrated multiple instances of unconscious or covert self-recognition. A variety of interventions, inspired by research with prosopagnosics, was implemented to remediate this loss. Interventions enabled all participants to exhibit overt self-recognition, though each did so with the aid of a different intervention. In addition, successful overt self-recognition required a verbal probe and was entirely intervention-dependent: When the intervention was removed, overt self-recognition was lost. Results support a dissociation between explicit–declarative versus implicit–nondeclarative memory systems, and extends this dissociation into the realm of self-recognition in AD. (JINS, 1997, 3, 195–198.)

Impaired Self–Recognition from Recent Photographs in a Case of Late–Stage Alzheimer's Disease

2005 ◽  
Vol 23 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Jessica A. Hehman ◽  
Tim P. German ◽  
Stanley B. Klein
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Stage ◽  
Self Recognition

scholarly journals Successful Combination Therapy of Trazodone and Fluvoxamine for Pica in Alzheimer's Disease: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Tadashi Kanamori ◽  
Yoshiyuki Kaneko ◽  
Kouju Yamada ◽  
Masahiro Suzuki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Report ◽  
Drug Therapy ◽  
Combination Therapy ◽  
Frontotemporal Dementia ◽  
Late Stage ◽  
Daytime Sleepiness ◽  
Extrapyramidal Symptoms ◽  
Common Drug

Pica in Alzheimer's disease (AD) makes it difficult for caregivers to provide care. However, few effective medications have been reported for pica in AD. We report a case of AD with pica that was successfully improved by trazodone and fluvoxamine. An 80-year-old woman with AD was admitted to our hospital due to aggravated pica, including eating weeds in the facility's garden and eating a dishwashing sponge. Her pica was accompanied by oral tendency, prosopagnosia, and placidity. She took rivastigmine and memantine, but these were ineffective for her pica. She was given olanzapine and perospirone, but both were discontinued due to over-sedation and severe extrapyramidal symptoms, respectively. We then administered trazodone and fluvoxamine, both of which have demonstrated effectiveness for pica in frontotemporal dementia (FTD). Her pica behaviors then disappeared without daytime sleepiness. In this case, pica with oral tendency, which was accompanied by prosopagnosia and placidity, may be interpreted as a partial symptom of Klüver–Bucy syndrome (KBS). KBS is often seen in FTD, but also occurs in late-stage AD. Our case together with previous reports showing that trazodone and fluvoxamine were effective for pica in FTD suggest that the same common drug therapy may be successful in pica with oral tendency, regardless of the subtype of dementia.

Estrogenic Regulation of Synaptic Health and Cognition in Aging Rhesus Monkeys

2020 ◽  
pp. 303-334
Author(s):  
Johanna L. Crimins ◽  
Yuko Hara ◽  
John H. Morrison
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Aging ◽  
Rhesus Monkeys ◽  
Memory Systems ◽  
Brain Regions ◽  
Clinical Literature ◽  
Menopausal Women ◽  
Dorsolateral Prefrontal ◽  
Estrogenic Regulation

A compelling case can be made for estrogen’s role in maintaining synaptic health in the context of cognitive aging. This chapter first reviews clinical literature pertinent to estrogenic actions on cognition in menopausal women. Next, the authors provide a comprehensive summary of recent investigations in aging rhesus monkeys, which have emerged as a particularly powerful model for the study of synaptic and cognitive effects of both natural and surgical menopause. In particular, we focus on hippocampal and dorsolateral prefrontal cortex neurons and circuits that degenerate in normal aging and Alzheimer’s disease. The responsiveness of these brain regions to estrogen and implications for their related memory systems are discussed. Finally, the chapter highlights work that needs to be done to more fully understand the molecular basis for the complex interplay between menopause, aging, and vulnerability to Alzheimer’s disease in higher cognitive function and synaptic health.

The effects of a Namaste care program on quality of life: A pilot study in Iranian women with late-stage Alzheimer's disease

2021 ◽  
Vol 42 (1) ◽  
pp. 78-82
Author(s):  
Zahra Amrollah Majdabadi Kohne ◽  
Nasrin Nikpeyma ◽  
Firoozeh Bayat ◽  
Mahvash Salsali ◽  
Paulette V. Hunter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pilot Study ◽  
Late Stage ◽  
Care Program ◽  
Iranian Women

scholarly journals RNA Oxidation Adducts 8-OHG and 8-OHA Change with Aβ42 Levels in Late-Stage Alzheimer's Disease

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24930 ◽  
Author(s):  
Adam M. Weidner ◽  
Melissa A. Bradley ◽  
Tina L. Beckett ◽  
Dana M. Niedowicz ◽  
Amy L. S. Dowling ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Stage ◽  
Rna Oxidation
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