scholarly journals Inhibition of phosphodiesterases relaxes urinary bladder smooth muscle via activation of the large conductance voltageand Ca 2+ ‐activated K + channels

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Wenkuan Xin ◽  
Qiuping Cheng ◽  
Rupal P. Soder ◽  
Georgi V. Petkov
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Bladder Smooth Muscle ◽  
K Channels ◽  
Urinary Bladder Smooth Muscle

scholarly journals SK4 Encodes Intermediate Conductance Ca2+-Activated K+ Channels in Mouse Urinary Bladder Smooth Muscle Cells

2000 ◽  
Vol 84 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Susumu Ohya ◽  
Shunichi Kimura ◽  
Mika Kitsukawa ◽  
Katsuhiko Muraki ◽  
Minoru Watanabe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Bladder Smooth Muscle ◽  
K Channels ◽  
Urinary Bladder Smooth Muscle

EVIDENCE FOR THE PRESENCE OF LARGE CONDUCTANCE CA 2+ -ACTIVATED K + CHANNELS IN NATIVE HUMAN URINARY BLADDER SMOOTH MUSCLE

2008 ◽  
Vol 179 (4S) ◽  
pp. 129-129 ◽  
Author(s):  
Kiril L Hristov ◽  
Xiangli Cui ◽  
Whitney F Kellett ◽  
Eric Rovner ◽  
Georgi Petkov
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Bladder Smooth Muscle ◽  
K Channels ◽  
Human Urinary Bladder ◽  
Urinary Bladder Smooth Muscle

Functional and molecular identification of pH-sensitive K+channels in murine urinary bladder smooth muscle

2008 ◽  
Vol 102 (1) ◽  
pp. 113-124 ◽  
Author(s):  
Elizabeth A.H. Beckett ◽  
Insoo Han ◽  
Salah A. Baker ◽  
Junguk Han ◽  
Fiona C. Britton ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Molecular Identification ◽  
Ph Sensitive ◽  
Bladder Smooth Muscle ◽  
K Channels ◽  
Urinary Bladder Smooth Muscle

Ca(2+)-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle

1997 ◽  
Vol 273 (1) ◽  
pp. C110-C117 ◽  
Author(s):  
T. J. Heppner ◽  
A. D. Bonev ◽  
M. T. Nelson
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Action Potential ◽  
Single Channel ◽  
Resting Membrane Potential ◽  
Channel Blockers ◽  
Bladder Smooth Muscle ◽  
Apparent Dissociation Constant ◽  
K Channels ◽  
Urinary Bladder Smooth Muscle

The goal of this study was to examine the role of large conductance Ca(2+)-activated K+ channels in the regulation of cell excitability in urinary bladder smooth muscle from the guinea pig. Ca(2+)-activated K+ channels were studied with single-channel recording techniques and found to be intracellular Ca2+ and voltage dependent and sensitive to external tetraethylammonium and blocked by nanomolar concentrations of iberiotoxin (apparent dissociation constant of 4 nM). Spontaneous action potentials recorded from intact tissue strips depended on external Ca2+ and were inhibited by Ca2+ channel blockers. Iberiotoxin (100 nM) significantly altered the configuration of the action potential by increasing the duration and peak amplitude of the action potential and decreasing the rate of decay. Iberiotoxin also increased the action potential frequency from 0.11 to 0.29 Hz. This study suggests that Ca(2+)-activated K+ channels play a significant role in the repolarization of the action potential and in the maintenance of the resting membrane potential of the urinary bladder smooth muscle.

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