scholarly journals Effects of Cfh genotype and dietary glycemic index on age‐related macular degeneration in mice

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Sheldon Rowan ◽  
Karen Weikel ◽  
Min‐Lee Chang ◽  
Barbara Nagel ◽  
Jeffrey Thinschmidt ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Glycemic Index ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Dietary Glycemic Index

scholarly journals CfhGenotype Interacts With Dietary Glycemic Index to Modulate Age-Related Macular Degeneration-Like Features in Mice

2014 ◽  
Vol 55 (1) ◽  
pp. 492 ◽  
Author(s):  
Sheldon Rowan ◽  
Karen Weikel ◽  
Min-Lee Chang ◽  
Barbara A. Nagel ◽  
Jeffrey S. Thinschmidt ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Glycemic Index ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Dietary Glycemic Index

scholarly journals Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration

2006 ◽  
Vol 83 (4) ◽  
pp. 880-886 ◽  
Author(s):  
Chung-Jung Chiu ◽  
Larry D Hubbard ◽  
Jane Armstrong ◽  
Gail Rogers ◽  
Paul F Jacques ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Glycemic Index ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related ◽  
Dietary Glycemic Index

Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration

2006 ◽  
Vol 142 (3) ◽  
pp. 535-536
Author(s):  
C.J. Chiu ◽  
L.D. Hubbard ◽  
J. Armstrong ◽  
G. Rogers ◽  
P.F. Jacques ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Glycemic Index ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related ◽  
Dietary Glycemic Index

scholarly journals Dietary glycemic index and the risk of age-related macular degeneration

2008 ◽  
Vol 88 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
Shweta Kaushik ◽  
Jie Jin Wang ◽  
Victoria Flood ◽  
Jennifer Sue Ling Tan ◽  
Alan W Barclay ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Glycemic Index ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Dietary Glycemic Index

scholarly journals Adalékok az időskori maculadegeneráció – etiopatogeneziséből fakadó – nem gyógyszeres intervenciójához

2015 ◽  
Vol 156 (28) ◽  
pp. 1128-1132 ◽  
Author(s):  
Tamás Fischer
Keyword(s):  
Endothelial Dysfunction ◽  
Macular Degeneration ◽  
Vascular Disease ◽  
Vascular Wall ◽  
Age Related Macular Degeneration ◽  
Omega 3 ◽  
Pharmacological Interventions ◽  
Therapeutic Implications ◽  
Age Related ◽  
Dietary Glycemic Index

It has a great therapeutic significance that the disorder of the vascular endothelium, which supplies the affected ocular structures, plays a major role in the development of age-related macular degeneration. Chronic inflammation is closely linked to diseases associated with endothelial dysfuncition and age-related macular degeneration is accompanied by a general inflammatory response. The vascular wall including those in chorioids may be activated by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic and genetic factors causing a protracted host defence response with a consequent vascular damage, which leads to age-related macular degeneration. Based on this concept, age-related macular degeneration is a local manifestation of the systemic vascular disease. This recognition should have therapeutic implications because restoration of endothelial dysfunction can stabilize the condition of chronic vascular disease including age-related macular degeneration, as well. Restoration of endothelial dysfunction by non-pharmacological or pharmacological interventions may prevent the development or improve endothelial dysfunction resulting in prevention or improvement of age-related macular degeneration. Non-pharmacological interventions which may have beneficial effect in endothelial dysfunction include (1) smoking cessation; (2) reduction of increased body weight; (3) adequate physical activity; (4) appropriate diet (a) proper dose of flavonoids, polyphenols and kurcumin; (b) omega-3 long-chain polyunsaturated fatty acids: docosahexaenoic acid and eicosapentaenoic acid; (c) carotenoids, lutein and zeaxanthins), (d) management of dietary glycemic index, (e) caloric restriction, and (5) elimination of stressful lifestyle. Non-pharmacological interventions should be preferable even if medicaments are also used for the treatment of endothelial dysfunction. Orv. Hetil., 2015, 156(28), 1128–1132.

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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