scholarly journals Uterine artery smooth muscle contractions are mediated by PKC and NO signaling mechanisms in diet‐induced obese pregnant rats (700.8)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Styliani Goulopoulou ◽  
Johanna Hannan ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Uterine Artery ◽  
Muscle Contractions ◽  
Pregnant Rats ◽  
Signaling Mechanisms ◽  
No Signaling ◽  
Smooth Muscle Contractions

194: Influence of the Inhibition of Cyclic Nucleotide Phosphodiesterase type 4 on Human Detrusor Smooth Muscle Contractions

2006 ◽  
Vol 175 (4S) ◽  
pp. 63-63 ◽  
Author(s):  
Stephanie Oger ◽  
Delphine Behr-Roussel ◽  
Jacques Bernabe ◽  
Pierre Denys ◽  
Eva Camperat ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Nucleotide ◽  
Muscle Contractions ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Detrusor Smooth Muscle ◽  
Phosphodiesterase Type ◽  
Smooth Muscle Contractions ◽  
Human Detrusor

Haloperidol differentiates smooth muscle contractions induced by release of intracellularly stored Ca and by influx of extracellular Ca

1992 ◽  
Vol 23 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Shigeru Hishinuma ◽  
Ikuko Hongo ◽  
Masaatsu K. Uchida ◽  
Masanori Kurokawa
Keyword(s):  
Smooth Muscle ◽  
Muscle Contractions ◽  
Smooth Muscle Contractions

Evaluation of Airway Smooth Muscle Contractions in Vitro by High-Frequency Ultrasonic Imaging

CHEST Journal ◽  
1992 ◽  
Vol 102 (4) ◽  
pp. 1251-1257 ◽  
Author(s):  
Kunihiko Iizuka ◽  
Kunio Dobashi ◽  
Shinobu Houjou ◽  
Hiromi Sakai ◽  
Kouichi Itoh ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
High Frequency ◽  
Ultrasonic Imaging ◽  
Muscle Contractions ◽  
Smooth Muscle Contractions

Shakuyaku-kanzo-to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro

2012 ◽  
Vol 38 (7) ◽  
pp. 1004-1010 ◽  
Author(s):  
Shoko Tsuji ◽  
Katsuhiko Yasuda ◽  
Genichiro Sumi ◽  
Hisayuu Cho ◽  
Tomoko Tsuzuki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Contractions ◽  
Uterine Tissue ◽  
Smooth Muscle Contractions

Enkephalinase Inhibitor Potentiates Substance P- and Capsaicin-induced Bronchial Smooth Muscle Contractions in Humans

1991 ◽  
Vol 143 (6) ◽  
pp. 1416-1418 ◽  
Author(s):  
Izumi Honda ◽  
Hirotsugu Kohrogi ◽  
Tetsuro Yamaguchi ◽  
Masayuki Ando ◽  
Shukuro Araki
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Muscle Contractions ◽  
Bronchial Smooth Muscle ◽  
Smooth Muscle Contractions

221. Localisation of relaxin receptors (Rxfp1) in the uterine artery and the effects of blocking circulating relaxin on passive mechanical wall properties in the uterine artery of late pregnant rats

2008 ◽  
Vol 20 (9) ◽  
pp. 21
Author(s):  
L. A. Vodstrcil ◽  
J. Novak ◽  
M. Tare ◽  
M. E. Wlodek ◽  
L. J. Parry
Keyword(s):  
Blood Flow ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Uterine Artery ◽  
Late Pregnancy ◽  
Artery Wall ◽  
Pregnant Rats ◽  
Uterine Arteries ◽  
Wall Properties ◽  
Wall Stiffness

During pregnancy, the uteroplacental circulation undergoes dramatic alterations to allow for the large increase in blood flow to the feto-placental unit. These alterations are achieved through several mechanisms including structural changes in the uterine artery wall and endothelium-dependent vasodilation. Small renal arteries of relaxin-deficient mice and rats have enhanced myogenic reactivity and decreased passive compliance, and are relatively vasoconstricted (Novak et al. 2001, 2006). To date, no study has identified relaxin receptors (Rxfp1) in arteries or investigated the effects of relaxin deficiency in pregnancy on uterine artery function. The aims of this current study were to: 1) localise Rxfp1 in the uterine arteries, 2) measure myogenic reactivity in small uterine arteries after relaxin treatment, and 3) test the hypothesis that blocking circulating relaxin in late pregnancy will increase uterine artery wall stiffness. We demonstrated that Rxfp1 is expressed in the uterine arteries of pregnant mice and rats. Brightfield immunohistochemistry and immunofluorescence using antibodies specific for rat Rxfp1, α-smooth muscle actin and CD31 localised Rxfp1 protein predominantly to the vascular smooth muscle in the uterine artery of pregnant rats. Administration of recombinant human H2 relaxin (4 ug/h) for 6 h or 5 days in intact and ovariectomised rats reduced myogenic reactivity of small uterine arteries in vitro. Pregnant rats were treated with a monoclonal antibody against circulating relaxin (MCA1) or control (MCAF) for 3 days (Days 17–19) and uterine arteries were mounted on a pressure myograph to assess passive mechanical wall properties. Neutralising circulating relaxin in late pregnancy resulted in a significant increase in uterine artery wall stiffness. These data demonstrate that relaxin acts on the vascular smooth muscle cells in the uterine artery and may be involved in the pregnancy-specific vascular remodelling of uterine arteries to increase vasodilation and blood flow to the uterus and placenta. (1) Novak J et al. (2001). J Clin Invest 107: 1469–75 (2) Novak J et al. (2006). FASEB J 20: 2352–62

Exogenous but not endogenous PGE2 modulates pony tracheal smooth muscle contractions

1992 ◽  
Vol 5 (4) ◽  
pp. 225-231 ◽  
Author(s):  
Z. Wang ◽  
M. Yu ◽  
N.E. Robinson ◽  
R.V. Broadstone ◽  
P.H. LeBlanc ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Contractions ◽  
Tracheal Smooth Muscle ◽  
Smooth Muscle Contractions

[OP.8C.02] SENESCENCE INCREASES VASCULAR SMOOTH MUSCLE CONTRACTIONS THROUGH INCREASED RHO KINASE ACTIVITY IN FEMALE MOUSE AORTA

2016 ◽  
Vol 34 ◽  
pp. e102
Author(s):  
S. Novella ◽  
X. Vidal-Gómez ◽  
I. Pérez-Monzó ◽  
A. Mompeón ◽  
D. Pérez-Cremades ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Female Mouse ◽  
Kinase Activity ◽  
Rho Kinase ◽  
Muscle Contractions ◽  
Mouse Aorta ◽  
Smooth Muscle Contractions
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