scholarly journals Do kappa opioid receptors regulate cardiovascular responses to severe haemorrhage in conscious newborn lambs? (859.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Francine Smith ◽  
Mohamed Samhan ◽  
Wei Qi
Keyword(s):  
Opioid Receptors ◽  
Cardiovascular Responses ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Severe Haemorrhage

CHARACTERIZATION OF KAPPA OPIOID RECEPTORS WITH TRITIATED norBNI

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 557-560 ◽  
Author(s):  
Á Márki ◽  
F. Ötvös ◽  
G. Tóth ◽  
S. Hosztafi ◽  
A. Borsodi
Keyword(s):  
Opioid Receptors ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid

Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors

2006 ◽  
Vol 1083 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Hiroaki Yamada ◽  
Naohito Shimoyama ◽  
Ichiro Sora ◽  
George R. Uhl ◽  
Yasuichiro Fukuda ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Kappa Opioid Receptors ◽  
Mu Opioid Receptors ◽  
Kappa Opioid ◽  
Mu Opioid

Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test

2013 ◽  
Vol 698 (1-3) ◽  
pp. 286-291 ◽  
Author(s):  
Carlos B. Filho ◽  
Lucian Del Fabbro ◽  
Marcelo G. de Gomes ◽  
André T.R. Goes ◽  
Leandro C. Souza ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Swimming Test

kappa-Opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury

1991 ◽  
Vol 261 (6) ◽  
pp. R1527-R1532 ◽  
Author(s):  
R. Vink ◽  
P. S. Portoghese ◽  
A. I. Faden
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Neurological Outcome ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Opioid Receptor Antagonist ◽  
Cellular Bioenergetics

Treatment with opioid receptor antagonists improves outcome after experimental brain trauma, although the mechanisms underlying the protective actions of these compounds remain speculative. We have proposed that endogenous opioids contribute to the pathophysiology of traumatic brain injury through actions at kappa-opioid receptors, possibly by affecting cellular bioenergetic state. In the present study, the effects of the kappa-selective opioid-receptor antagonist nor-binaltorphimine (nor-BNI) were examined after fluid percussion brain injury in rats. Metabolic changes were evaluated by 31P magnetic resonance spectroscopy; the same animals were subsequently followed over 2 wk to evaluate neurological recovery. Nor-BNI, administered intravenously as a 10 or 20 mg/kg bolus at 30 min after injury, significantly improved neurological outcome at 2 wk posttrauma compared with controls. Animals treated with nor-BNI showed significantly greater recovery of intracellular free magnesium concentrations and cytosolic phosphorylation potentials during the first 4 h after injury compared with saline-treated controls. The improvement in cytosolic phosphorylation potential was significantly correlated to neurological outcome. These data support the hypothesis that kappa-opioid receptors mediate pathophysiological changes after traumatic brain injury and that the beneficial effects of opioid-receptor antagonist may result from improvement of posttraumatic cellular bioenergetics.

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