scholarly journals TAS2R bitter taste receptors regulate thyroid function

2014 ◽  
Vol 29 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Adam A. Clark ◽  
Cedrick D. Dotson ◽  
Amanda E. T. Elson ◽  
Anja Voigt ◽  
Ulrich Boehm ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Bitter Taste ◽  
Taste Receptors ◽  
Bitter Taste Receptors

M1659 Agonists of Bitter Taste Receptors Activate the Gut-Brain Axis and Influence Food Intake and Gastrointestinal Function in Mice

2008 ◽  
Vol 134 (4) ◽  
pp. A-392
Author(s):  
Shuzhen Hao ◽  
Elvis G. Espero ◽  
Michelle Dulake ◽  
Catia Sternini ◽  
Linda Rinaman ◽  
...  
Keyword(s):  
Food Intake ◽  
Bitter Taste ◽  
Gastrointestinal Function ◽  
Taste Receptors ◽  
Bitter Taste Receptors

Bitter Taste Receptors (TAS2RS) Regulate Gastric Accommodation Following Liquid Meal Administration in Guinea Pigs

2017 ◽  
Vol 152 (5) ◽  
pp. S934
Author(s):  
Yumi Harada ◽  
Junichi Koseki ◽  
Hitomi Sekine ◽  
Naoki Fujitsuka ◽  
Tomohisa Hattori ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Bitter Taste ◽  
Taste Receptors ◽  
Gastric Accommodation ◽  
Liquid Meal ◽  
Bitter Taste Receptors

Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

2021 ◽  
Author(s):  
Ichie Ojiro ◽  
Hiromi Nishio ◽  
Toyomi Yamazaki-Ito ◽  
Shogo Nakano ◽  
Sohei Ito ◽  
...  
Keyword(s):  
Functional Food ◽  
Functional Foods ◽  
Bitter Taste ◽  
Functional Characteristic ◽  
Taste Receptors ◽  
Food Ingredients ◽  
Masking Agents ◽  
Bitter Taste Receptors ◽  
Bitterness Masking

Abstract Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multi-functional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.

scholarly journals Personalized expression of bitter ‘taste’ receptors in human skin

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205322 ◽  
Author(s):  
Lauren Shaw ◽  
Corrine Mansfield ◽  
Lauren Colquitt ◽  
Cailu Lin ◽  
Jaime Ferreira ◽  
...  
Keyword(s):  
Human Skin ◽  
Bitter Taste ◽  
Taste Receptors ◽  
Bitter Taste Receptors

scholarly journals Bitter Taste Receptors Expression in Human Granulosa and Cumulus Cells: New Perspectives in Female Fertility

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3127
Author(s):  
Bianca Semplici ◽  
Francesca Paola Luongo ◽  
Sofia Passaponti ◽  
Claudia Landi ◽  
Laura Governini ◽  
...  
Keyword(s):  
Reproductive System ◽  
Bitter Taste ◽  
Receptor Activation ◽  
Female Fertility ◽  
Human Reproduction ◽  
Receptor Subtype ◽  
Taste Receptors ◽  
Female Reproductive System ◽  
Bitter Taste Receptors

Bitter taste receptors (TAS2RS) expression is not restricted to the oral cavity and the presence of these receptors in the male reproductive system and sperm provides insights into their possible role in human reproduction. To elucidate the potential role of TAS2Rs in the female reproductive system, we investigated the expression and localization of bitter taste receptors and the components of signal transduction cascade involved in the pathway of taste receptors in somatic follicular cells obtained from women undergoing assisted reproductive techniques. We found that TAS2R genes are expressed in both cumulus (CCs) and granulosa (GCs) cells, with TAS2R14 being the most highly expressed bitter receptor subtype. Interestingly, a slight increase in the expression of TAS2R14 and TAS2R43 was shown in both GCs and CCs in young women (p < 0.05), while a negative correlation may be established between the number of oocytes collected at the pickup and the expression of TAS2R43. Regarding α-gustducin and α-transducin, two Gα subunits expressed in the taste buds on the tongue, we provide evidence for their expression in CCs and GCs, with α-gustducin showing two additional isoforms in GCs. Finally, we shed light on the possible downstream transduction pathway initiated by taste receptor activation in the female reproductive system. Our study, showing for the first time the expression of taste receptors in the somatic ovarian follicle cells, significantly extends the current knowledge of the biological role of TAS2Rs for human female fertility.

Sign in / Sign up

Export Citation Format

Share Document