Preservation of endoplasmic reticulum (ER) Ca 2+ stores by deletion of inositol‐1,4,5‐trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide‐gated channel‐deficient cone photoreceptors

2021 ◽  
Vol 35 (6) ◽  
Author(s):  
Fan Yang ◽  
Hongwei Ma ◽  
Michael R. Butler ◽  
Xi‐Qin Ding
Keyword(s):  
Endoplasmic Reticulum ◽  
Cyclic Nucleotide ◽  
Outer Segment ◽  
Receptor Type ◽  
Cone Photoreceptors ◽  
Inositol 1,4,5 Trisphosphate ◽  
Gated Channel ◽  
Trisphosphate Receptor

scholarly journals cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

2015 ◽  
Vol 290 (34) ◽  
pp. 20880-20892 ◽  
Author(s):  
Hongwei Ma ◽  
Michael R. Butler ◽  
Arjun Thapa ◽  
Josh Belcher ◽  
Fan Yang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Er Stress ◽  
Cyclic Nucleotide ◽  
Protein Kinase G ◽  
Cng Channel ◽  
Inositol 1,4,5 Trisphosphate ◽  
Gated Channel ◽  
Trisphosphate Receptor ◽  
Deficient Mice

Photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction. Mutations in the cone CNG channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophies. We have shown endoplasmic reticulum (ER) stress-associated apoptotic cone death and increased phosphorylation of the ER Ca2+ channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG channel-deficient mice. We also presented a remarkable elevation of cGMP and an increased activity of the cGMP-dependent protein kinase (protein kinase G, PKG) in CNG channel deficiency. This work investigated whether cGMP/PKG signaling regulates ER stress and IP3R1 phosphorylation in CNG channel-deficient cones. Treatment with PKG inhibitor and deletion of guanylate cyclase-1 (GC1), the enzyme producing cGMP in cones, were used to suppress cGMP/PKG signaling in cone-dominant Cnga3−/−/Nrl−/− mice. We found that treatment with PKG inhibitor or deletion of GC1 effectively reduced apoptotic cone death, increased expression levels of cone proteins, and decreased activation of Müller glial cells. Furthermore, we observed significantly increased phosphorylation of IP3R1 and reduced ER stress. Our findings demonstrate a role of cGMP/PKG signaling in ER stress and ER Ca2+ channel regulation and provide insights into the mechanism of cone degeneration in CNG channel deficiency.

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

Cell Calcium ◽  
2006 ◽  
Vol 40 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Nael Nadif Kasri ◽  
Sarah L. Kocks ◽  
Leen Verbert ◽  
Sébastien S. Hébert ◽  
Geert Callewaert ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Receptor Type ◽  
Knock Out ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

Differential modulation of inositol 1,4,5-trisphosphate receptor type 1 and type 3 by ATP

Cell Calcium ◽  
2000 ◽  
Vol 27 (5) ◽  
pp. 257-267 ◽  
Author(s):  
K. Maes ◽  
L. Missiaen ◽  
P. De Smet ◽  
S. Vanlingen ◽  
G. Callewaert ◽  
...  
Keyword(s):  
Receptor Type ◽  
Differential Modulation ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor ◽  
Type 3

scholarly journals Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation

Cell Calcium ◽  
2009 ◽  
Vol 46 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Veerle Vanderheyden ◽  
Takuya Wakai ◽  
Geert Bultynck ◽  
Humbert De Smedt ◽  
Jan B. Parys ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Receptor Type ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals Cdc2/Cyclin B1 Interacts with and Modulates Inositol 1,4,5-Trisphosphate Receptor (Type 1) Functions

2005 ◽  
Vol 175 (9) ◽  
pp. 6205-6210 ◽  
Author(s):  
Xiaogui Li ◽  
Krishnamurthy Malathi ◽  
Olga Krizanova ◽  
Karol Ondrias ◽  
Kirk Sperber ◽  
...  
Keyword(s):  
Cyclin B1 ◽  
Receptor Type ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

4.1N binding regions of inositol 1,4,5-trisphosphate receptor type 1

2006 ◽  
Vol 342 (2) ◽  
pp. 573-576 ◽  
Author(s):  
Kazumi Fukatsu ◽  
Hiroko Bannai ◽  
Takafumi Inoue ◽  
Katsuhiko Mikoshiba
Keyword(s):  
Receptor Type ◽  
Inositol 1,4,5 Trisphosphate ◽  
Binding Regions ◽  
Trisphosphate Receptor
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