8‐ iso ‐prostaglandin E 2 induces nasal obstruction via thromboxane receptor in murine model of allergic rhinitis

2021 ◽  
Vol 35 (10) ◽  
Author(s):  
Tatsuro Nakamura ◽  
Yuri Tachibana ◽  
Takahisa Murata
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Obstruction ◽  
Murine Model ◽  
Prostaglandin E ◽  
Thromboxane Receptor

scholarly journals Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model

2021 ◽  
Vol 141 ◽  
pp. 111944
Author(s):  
Susanna Choi ◽  
Myung-A Jung ◽  
Youn-Hwan Hwang ◽  
Bo-Jeong Pyun ◽  
Joo Young Lee ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Asarum Heterotropoides

Nasal Cytology in Radiofrequency Turbinate Volume Reduction

ORL ◽  
2021 ◽  
pp. 1-6
Author(s):  
Giancarlo Pecorari ◽  
Giuseppe Riva ◽  
Claudia Bartoli ◽  
Mattia Ravera ◽  
Valeria Dell’Era ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Effective Treatment ◽  
Nasal Obstruction ◽  
Nasal Mucosa ◽  
Inferior Turbinate ◽  
Volume Reduction ◽  
Nonallergic Rhinitis ◽  
Turbinate Hypertrophy ◽  
Nasal Cytology ◽  
Rhinitis Medicamentosa

Introduction: Radiofrequency turbinate volume reduction (RFTVR) is an effective treatment of inferior turbinate hypertrophy. RFTVR can reduce epithelial cell alterations in nasal mucosa. The aim of this observational study was to evaluate the effects of RFTVR on nasal obstruction and cytology, stratifying for different types of rhinitis. Methods: Nasal cytology and subjective nasal obstruction were evaluated on 113 patients before RFTVR (T0) and after 3 months (T1). The patients were divided into groups on the basis of the underlying disease: allergic rhinitis, nonallergic rhinitis, rhinitis medicamentosa, and other diseases (e.g., hormonal-based turbinate hypertrophy). Results: Nasal cytology at T0 identified 42 patients with allergic rhinitis, 40 with nonallergic rhinitis, 19 with rhinitis medicamentosa, and 12 with other diseases. An improvement of nasal cytology at T1 was observed in 29.2% of cases. They mainly consisted of patients with nonallergic rhinitis with neutrophils, whose neutrophil infiltrate decreased. Only 2 cases (1.7%) showed a worsening of nasal cytology at T1. A statistically significant decrease in subjective nasal obstruction was observed for every group (p < 0.05). Higher differences of nasal obstruction between T0 and T1 were found in patients with rhinitis medicamentosa or other diseases. Conclusion: RFTVR represents a safe and effective treatment for turbinate hypertrophy of various etiology. It is not responsible for a worsening of inflammatory infiltrate of the nasal mucosa.

Allergic rhinitis versus Idiopathic rhinitis: Are there differences in the symptomatology and nasal obstruction?

2019 ◽  
Vol 59 (6) ◽  
pp. 434-439
Author(s):  
M. Mayo-Yáñez ◽  
J. Villares-Soriano ◽  
C. Calvo-Henríquez ◽  
JC. Vázquez-Barro ◽  
J. Herranz González-Botas ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Obstruction ◽  
Idiopathic Rhinitis

Intranasal budesonide in children affected by persistent allergic rhinitis and its effect on nasal patency and Nasal Obstruction Symptom Evaluation (NOSE) score

2015 ◽  
Vol 31 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Anna Maria Zicari ◽  
Francesca Occasi ◽  
Montanari Giulia ◽  
Luciana Indinnimeo ◽  
Giovanna De Castro ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Obstruction ◽  
Nasal Patency ◽  
Persistent Allergic Rhinitis ◽  
Symptom Evaluation

Clinical Outcome of CO2 Laser Inferior Turbinate Reduction in Patients with Nasal Obstruction Due to Inferior Turbinate Hypertrophy in a Tertiary Care Centre, Thiruvananthapuram, Kerala

2021 ◽  
Vol 8 (30) ◽  
pp. 2778-2783
Author(s):  
Nikhila Rajendran ◽  
Jaya C ◽  
Venugopal M ◽  
Satheesh S
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Outcome ◽  
Medical Treatment ◽  
Nasal Obstruction ◽  
Co2 Laser ◽  
Inferior Turbinate ◽  
Turbinate Hypertrophy ◽  
Inferior Turbinate Hypertrophy ◽  
Turbinate Reduction

BACKGROUND Nasal obstruction secondary to inferior turbinate hypertrophy significantly affects the quality of life. Patients refractory to medical treatment are taken up for surgery. Laser turbinate reduction is an effective and simple method for treatment of nasal obstruction due to inferior turbinate hypertrophy. Only a few studies reported on the outcome of laser inferior turbinate reduction in India. The present study was done to assess the clinical outcome of laser inferior turbinate reduction in patients with nasal obstruction due to inferior turbinate hypertrophy. METHODS This prospective observational study was done in 31 patients (18 – 60 years) with nasal obstruction due to inferior turbinate hypertrophy refractory to medical management who underwent laser inferior turbinate reduction in ENT Department, Government Medical College, Thiruvananthapuram from December 2017 to September 2019. RESULTS All patients had bilateral inferior turbinate hypertrophy. 21 out of 31 patients had allergic rhinitis and rest had non-allergic rhinitis. Pre-operatively most patients had symptom score between 15 and 20. After CO2 laser inferior turbinate reduction at the end of 3 months of follow up, subjective assessment by symptom scoring confirmed by objective assessment by flowmetry 29 out of 31 patients had good outcome with relief from nasal obstruction. The success rate was more in nonallergic rhinitis (100 %) than the allergic rhinitis group (90.47 %). CONCLUSIONS CO2 laser inferior turbinate reduction is an effective procedure to relieve nasal obstruction in patients with inferior turbinate hypertrophy refractory to medical treatment, with minimal complications. Post-procedure on follow up significant number of patients had relief from hyposmia, sneezing and running nose. KEYWORDS Nasal Obstruction, Peak Nasal Inspiratory Flowmetry, Symptom Scoring, CO2 Laser, Outcome

Site-specific sensitization in a murine model of allergic rhinitis: Role of the upper airway in lower airways disease

2002 ◽  
Vol 110 (6) ◽  
pp. 891-898 ◽  
Author(s):  
Christine McCusker ◽  
Martin Chicoine ◽  
Qutayba Hamid ◽  
Bruce Mazer
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Upper Airway ◽  
Site Specific ◽  
Lower Airways

Hematopoietic Prostaglandin D Synthase Is a Useful Target For Treating Nasal Obstruction In Guinea Pigs With Allergic Rhinitis

2014 ◽  
Vol 133 (2) ◽  
pp. AB134
Author(s):  
Daisuke Kajiwara ◽  
Hiroki Aoyagi ◽  
Kazuhiko Shigeno ◽  
Katsunao Tanaka ◽  
Eiji Sasaki ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Obstruction ◽  
Guinea Pigs ◽  
Prostaglandin D Synthase

Relationship between Responses to Bronchodilation Testing and to Nasal Decongestion Testing in Patients with Allergic Rhinitis Alone

2009 ◽  
Vol 7 (3) ◽  
pp. 153-160 ◽  
Author(s):  
G. Ciprandi ◽  
A. Pistorio ◽  
M.A. Tosca ◽  
I. Cirillo ◽  
G.L. Marseglia
Keyword(s):  
Allergic Rhinitis ◽  
Skin Prick Test ◽  
Nasal Obstruction ◽  
Clinical Examination ◽  
Positive Response ◽  
Bronchial Obstruction ◽  
Prick Test ◽  
Large Group ◽  
Lower Airways

A remarkable relationship exists between upper and lower airways. Bronchial obstruction is a paramount feature of asthma as well as nasal obstruction of allergic rhinitis (AR). This study aims to evaluate the response to both bronchodilation and decongestion testing and their relationships in a large group of patients with moderate-severe persistent AR alone. Two hundred eleven patients with moderate-severe persistent AR were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry, bronchodilation test, rhinomanometry, and decongestion test were performed on all patients. Seventeen subjects (8%) did not respond to any of the tests, 55 subjects (26.1%) were responders only to the decongestion test, 31 (14.7%) only to the bronchodilation test, and 108 subjects (51.2%) responded to both these tests. Longer AR duration was significantly associated with positive response to both tests (p<0.01). In conclusion, this study provides the first evidence that patients with moderate-severe persistent AR may frequently show reversibility to both bronchodilation and decongestion tests.

scholarly journals Allergic rhinitis and pregnancy – management

2017 ◽  
Vol 12 (2) ◽  
pp. 38-40
Author(s):  
Adriana TUDOSE ◽  
◽  
Radu MATEESCU ◽  
Alexandru MATEI ◽  
Edu ANTOINE ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Chronic Inflammation ◽  
Nasal Obstruction ◽  
Saline Solution ◽  
In Vitro Tests ◽  
Ige Antibodies

Allergic rhinitis is a chronic inflammation produced by the action of IgE antibodies which fight against allergens inside the mucosal nazale. It is characterized by symptoms such as nasal obstruction and/or watery rhinorrhea, sneezing and itching. Pregnancy is a temporary testing contraindication. During the pregnancy to detect the allergens involved in the symptoms we advise you to only take in vitro tests. The best approach in the management of rhinitis is to avoid allergens. Patients with mild to moderate rhinitis can only control the symptoms using nasal saline solution administered topically. Antihistamines can be useful during the pregnancy. Immunotherapy has not been found to be teratogenic and is clinically useful in relieving symptoms. The usage of oral decongestans and/or topical is controversial.

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