THE NATURE AND THE LESIONS OF CIRRHOSIS OF THE LIVER, WITH SPECIAL REFERENCE TO THE REGENERATION AND REARRANGEMENT OF THE LIVER PARENCHYMA

SummaryFactor XIII, estimated according to the method of Heene, was found to be diminished in patients with cirrhosis of the liver, in acute renal failure and, to a lesser extent, postoperatively, owing probably to both a decreased synthesis and an accelerated utilization. When compared to values obtained in healthy, normal weight, normolipemic control subjects, the level of factor XIII was higher in hyperlipemic and especially in hypertriglyceridemic patients, whether clinical atherosclerosis was present or not. Low levels of factor XIII were usually accompanied by a decrease in serum pseudocholinesterase, while high values of this enzyme produced by the liver were noted in hypertriglyceridemic patients. The hypothesis of an enhanced synthesis of factor XIII by the liver, in subjects with endogenous hypertriglyceridemia is considered. It is also suggested that accelerated stabilization of fibrin might contribute to the fibrinolytic insufficiency of hyperlipemic patients and enhance certain atherogenic mechanisms.

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CHARACTERISTICS OF AUTOPSY MATERIAL IN CASES OF CHRONIC DIFFUSE PATHOLOGY OF THE LIVER PARENCHYMA DIAGNOSED DURING PATIENT’S LIFETIME USING THE ULTRASOUND METHOD

Wiadomości Lekarskie ◽

10.36740/wlek202009218 ◽

2020 ◽

Vol 73 (9) ◽

pp. 1995-1999

Author(s):

Yuliia Ya. Fedulenkova ◽

Mykhailo S. Myroshnychenko ◽

Olha M. Astapieva ◽

Aleksandr A. Fatieiev ◽

Kristina Od. Akritova ◽

...

Keyword(s):

Malignant Tumors ◽

Relative Number ◽

Liver Parenchyma ◽

Cirrhosis Of The Liver ◽

Leukemic Cells ◽

Archival Material ◽

Liver Abscesses ◽

Pathology Of The Liver ◽

Metastatic Liver ◽

Tumors Of The Liver

The aim: Of the study is to analyze autopsy cases where chronic diffuse pathology of the liver parenchyma was diagnosed during patient’s lifetime using the ultrasound method. Material and methods: In this study archival material (autopsy protocols and microspecimens of these cases) of the pathological anatomy department of the Communal Nonprofit Enterprise «Regional Clinical Hospital» (Kharkiv) was used for the period from 2012 to 2018. The cases diagnosed with a chronic diffuse pathology of the liver parenchyma according to ultrasound data were selected among all cases. Microspecimens stained with hematoxylin and eosin, picrofuxin according to van Gieson were examined using an Olympus BX-41 microscope (Japan). The obtained digital indicators were statistically processed using the programs Statistica 6.0, Microsoft Excel 2003. To compare the parameters, parametric and nonparametric methods were used (Student’s t-test, χ2 criterion, Mann-Whitney U-test). Differences were considered significant at p<0.05. Results: According to the analysis of archival material for the period from 2012 to 2018, there was no change in the relative number of cases with fatty hepatosis, fibrosis or cirrhosis of the liver, chronic hepatitis, malignant tumors of the liver, metastatic liver damage and liver infiltration by leukemic cells, liver abscesses. Among all cases with revealed liver pathology, both separately by year and as a whole for the entire studied period, a predominance of the relative number of cases with fatty hepatosis, fibrosis or cirrhosis of the liver was noted. Conclusions: The term «chronic diffuse pathology of the liver parenchyma», which is widely used in ultrasound diagnostics, is morphologically a collective term that combines pathological conditions such as fatty hepatosis, fibrosis or cirrhosis of the liver, chronic hepatitis, malignant tumors of the liver, metastatic liver damage and liver infiltration by leukemic cells, liver abscesses. The ultrasound term «chronic diffuse pathology of the liver parenchyma» needs to be improved as well as additional diagnostic criteria should be developed in order to correctly use it in practice and avoid diagnostic errors.

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