AGE DEPENDENT DOSE REQUIREMENTS OF PROPOFOL IN TOTAL INTRAVENOUS ANESTHESIA AS QUANTIFIED BY CLOSED-LOOP EEG FEED-BACK INFUSION STRATEGIES

1992 ◽  
Vol 77 (Supplement) ◽  
pp. A338 ◽  
Author(s):  
J. Schüttler ◽  
S. Kloos ◽  
H. Röpcke ◽  
H. Ihmsen
Keyword(s):  
Closed Loop ◽  
Total Intravenous Anesthesia ◽  
Intravenous Anesthesia ◽  
Age Dependent

scholarly journals Technical and clinical evaluation of a closed loop TIVA system with SEDLineTM spectral density monitoring: Multicentric prospective cohort study

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Claudia Castellanos Peñaranda ◽  
Fabián D. Casas Arroyave ◽  
Francisco J. Gómez ◽  
Paola A. Pinzón Corredor ◽  
Juan M. Fernández ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort ◽  
Closed Loop ◽  
Clinical Performance ◽  
Total Intravenous Anesthesia ◽  
Closed Loop System ◽  
Intravenous Anesthesia ◽  
Anesthetic Depth ◽  
Maintenance Time ◽  
Performance Error

Abstract Introduction Closed loop total intravenous anesthesia is a technique in which the patient’s hemodynamic and anesthetic depth variables are monitored, and based on this information, a computer controls the infusion rate of drugs to keep them within pre-established clinical parameters. Objective To describe the technical and clinical performance of a closed loop system for total intravenous anesthesia with propofol and remifentanil, using the SEDLineTM monitor Design Multicentric prospective cohort study Setting Surgery room Patients ASA I-II undergoing elective surgery Measurements The authors designed a closed loop system that implements a control algorithm based on anesthetic depth monitoring and the Patient State Index (PSITM) of the SEDLine monitor for propofol, and on hemodynamic variables for remifentanil. The measurement of clinical performance was made based on the percentage of PSITM maintenance time in the range 20–50. Precision analysis was evaluated by measuring median performance error (MDPE) can be defined as the median difference between actual and desired values, which refers to the degree of precision in which the controller is able to maintain the control variable within the objective set by the anesthesiologist; it represents the direction (over-prediction or under-prediction) of performance error (PE) rather than size of errors, which is represented by MDAPE, median absolute percentage error, Wobble index, which is used for measuring the intrasubject variability in performance error. Results Data were obtained from 93 patients in three healthcare centers. The percentage of PSITM maintenance time in the 20–50 range was 92% (80.7–97.0). MDPE was 10.7 (− 11.0–18.0), MDAPE 21.0 (14.2–26.8) and wobble 10.7 (7.0–16.9). No adverse surgical or anesthetic events were found. Conclusions The closed loop total intravenous anesthesia system with SEDLine developed by the authors was used without major complication and appear to be feasible its use in clinical performance.

Closed-Loop Control of Total Intravenous Anesthesia During Significant Intraoperative Blood Loss

2017 ◽  
Vol 9 (8) ◽  
pp. 239-243 ◽  
Author(s):  
Sonia M. Brodie ◽  
Matthias Görges ◽  
J. Mark Ansermino ◽  
Guy A. Dumont ◽  
Richard N. Merchant
Keyword(s):  
Blood Loss ◽  
Closed Loop ◽  
Total Intravenous Anesthesia ◽  
Closed Loop Control ◽  
Intraoperative Blood Loss ◽  
Intravenous Anesthesia ◽  
Loop Control

CLOSED-LOOP SYSTEM FOR TOTAL INTRAVENOUS ANESTHESIA

1999 ◽  
Vol 88 (Supplement) ◽  
pp. 203S ◽  
Author(s):  
X.S. Zhang ◽  
R.J. Roy ◽  
J.W. Huang
Keyword(s):  
Closed Loop ◽  
Loop System ◽  
Total Intravenous Anesthesia ◽  
Closed Loop System ◽  
Intravenous Anesthesia

Total intravenous anesthesia in a closed loop system: Report of the first case in Colombia☆

2013 ◽  
Vol 41 (4) ◽  
pp. 306-310
Author(s):  
Francisco Javier Gómez Oquendo ◽  
Fabián David Casas Arroyave ◽  
Juan Manuel Fernández ◽  
Álvaro Guarín Grisales
Keyword(s):  
Closed Loop ◽  
Loop System ◽  
Total Intravenous Anesthesia ◽  
Closed Loop System ◽  
Intravenous Anesthesia ◽  
First Case

scholarly journals Quantitation of the Effect of Nitrous Oxide on Rocuronium Infusion Requirements Using Closed-loop Feedback Control

2008 ◽  
Vol 108 (3) ◽  
pp. 388-391 ◽  
Author(s):  
Hanna Illman ◽  
Heikki Antila ◽  
Klaus T. Olkkola
Keyword(s):  
Nitrous Oxide ◽  
Steady State ◽  
Feedback Control ◽  
Closed Loop ◽  
Neuromuscular Block ◽  
Total Intravenous Anesthesia ◽  
Minor Effect ◽  
Intravenous Anesthesia ◽  
Loop Feedback ◽  
Closed Loop Feedback

Background Nitrous oxide has a minor effect on the effective dose 50% values of bolus doses of rocuronium. The authors have studied the effect of nitrous oxide on the infusion requirements of rocuronium using closed-loop feedback control of rocuronium infusion. Methods The authors obtained institutional approval and informed consent to study 70 patients. The patients were given total intravenous anesthesia with propofol and remifentanil by target-controlled infusion and were randomly assigned to one of two groups, one receiving nitrous oxide with 30% oxygen (n = 35) and the other group receiving air with 30% oxygen (n = 35). The possible interaction of rocuronium with nitrous oxide was quantitated by determining the asymptotic steady state rate of infusion of rocuronium necessary to produce a constant 90% neuromuscular block. This was accomplished by applying nonlinear curve fitting to data on the cumulative dose requirement during the initial 90-min period after bolus administration of rocuronium. Results Patient characteristics and controller performance, i.e., the ability of the controller to maintain the neuromuscular block constant at the set point, did not differ significantly between the groups. The administration of nitrous oxide did not affect rocuronium infusion requirements. The mean steady state rates of infusion were 33.0 +/- 9.8 and 36.9 +/- 13.2 mg/h in the nitrous oxide-total intravenous anesthesia and air-total intravenous anesthesia groups, respectively. Conclusions Nitrous oxide does not affect the infusion requirements of rocuronium to a clinically significant degree.

scholarly journals Total intravenous anesthesia in a closed loop system: Report of the first case in Colombia

2013 ◽  
Vol 41 (4) ◽  
pp. 306-310 ◽  
Author(s):  
Francisco Javier Gómez Oquendo ◽  
Fabián David Casas Arroyave ◽  
Juan Manuel Fernández ◽  
Álvaro Guarín Grisales
Keyword(s):  
Closed Loop ◽  
Loop System ◽  
Total Intravenous Anesthesia ◽  
Closed Loop System ◽  
Intravenous Anesthesia ◽  
First Case
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