Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema

A three-dimensional magnetic resonance imaging (MRI) method to measure pulmonary edema and lung microvascular barrier permeability was developed and compared with conventional methods in nine mongrel dogs. MRIs were obtained covering the entire lungs. Injury was induced by injection of oleic acid (0.021–0.048 ml/kg) into a jugular catheter. Imaging followed for 0.75–2 h. Extravascular lung water and permeability-related parameters were measured from multiple-indicator dilution curves. Edema was measured as magnetic resonance signal-to-noise ratio (SNR). Postinjury wet-to-dry lung weight ratio was 5.30 ± 0.38 ( n = 9). Extravascular lung water increased from 2.03 ± 1.11 to 3.00 ± 1.45 ml/g ( n = 9, P < 0.01). Indicator dilution studies yielded parameters characterizing capillary exchange of urea and butanediol: the product of the square root of equivalent diffusivity of escape from the capillary and capillary surface area ( D 1/2 S) and the capillary permeability-surface area product ( PS). The ratio of D 1/2 Sfor urea to D 1/2 Sfor butanediol increased from 0.583 ± 0.027 to 0.852 ± 0.154 ( n = 9, P < 0.05). Whole lung SNR at baseline, before injury, correlated with D 1/2 Sand PS ratios (both P < 0.02). By using rate of SNR change, the mismatch of transcapillary filtration flow and lymph clearance was estimated to be 0.2–1.8 ml/min. The filtration coefficient was estimated from these values. Results indicate that pulmonary edema formation during oleic acid injury can be imaged regionally and quantified globally, and the results suggest possible regional quantification by using three-dimensional MRI.

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The potential role of atrial natriuretic peptide in the effects of Angiotensin-(1–7) in a chronic atrial tachycardia canine model

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320315627409 ◽

2016 ◽

Vol 17 (1) ◽

pp. 147032031562740 ◽

Cited By ~ 5

Author(s):

Jun Zhao ◽

Tiecheng Liu ◽

Enzhao Liu ◽

Guangping Li ◽

Lingshan Qi ◽

...

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Atrial Tachycardia ◽

Potential Role ◽

Canine Model ◽

Atrial Natriuretic

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Effect of ventilatory patterns during cardio-pulmonary bypass on extravascular lung water, pulmonary gas exchange and haemodynamics following extracorporeal circulation

Journal of Cardiothoracic Anesthesia ◽

10.1016/0888-6296(90)90074-p ◽

1990 ◽

Vol 4 (6) ◽

pp. 3

Author(s):

F.X. Schmid ◽

L. Brandt ◽

U. Hake ◽

H. Oelert

Keyword(s):

Gas Exchange ◽

Extracorporeal Circulation ◽

Extravascular Lung Water ◽

Pulmonary Gas Exchange ◽

Lung Water ◽

Cardio Pulmonary Bypass ◽

Pulmonary Bypass

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M-Atrial Natriuretic Peptide: A Novel Designer Natriuretic Peptide with Sustained Blood Pressure Lowering and Cyclic GMP Activating Actions in a Chronic Canine Model of Angiotensin II-Induced Hypertension

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2014.06.010 ◽

2014 ◽

Vol 20 (8) ◽

pp. S2

Author(s):

Giuseppe Puccia ◽

Sasantha J. Sangaralingham ◽

Gail Harty ◽

Alessandro Cataliotti ◽

Tomoko Ichiki ◽

...

Keyword(s):

Blood Pressure ◽

Angiotensin Ii ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Cyclic Gmp ◽

Canine Model ◽

Blood Pressure Lowering ◽

Induced Hypertension ◽

Pressure Lowering ◽

Atrial Natriuretic

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Effect of intravenous atrial natriuretic peptide on gas exchange in humans

Peptides ◽

10.1016/0196-9781(94)90102-3 ◽

1994 ◽

Vol 15 (4) ◽

pp. 719-721 ◽

Cited By ~ 3

Author(s):

M. Wong ◽

R. Demnati ◽

M.C. Michoud ◽

A. Robichaud ◽

J.R. Cusson ◽

...

Keyword(s):

Gas Exchange ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Atrial Natriuretic

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Acid-base status affects gas exchange in canine oleic acid pulmonary edema

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1991.260.4.h1080 ◽

1991 ◽

Vol 260 (4) ◽

pp. H1080-H1086 ◽

Cited By ~ 2

Author(s):

S. Brimioulle ◽

J. L. Vachiery ◽

P. Lejeune ◽

M. Leeman ◽

C. Melot ◽

...

Keyword(s):

Oleic Acid ◽

Metabolic Acidosis ◽

Gas Exchange ◽

Pulmonary Edema ◽

Sulfur Hexafluoride ◽

Respiratory Acidosis ◽

Pulmonary Gas Exchange ◽

Intrapulmonary Shunt ◽

Pulmonary Hemodynamics ◽

Acid Base Status

The effects of acidosis and alkalosis on pulmonary gas exchange were studied in 32 pentobarbital sodium-anesthetized intact dogs after induction of oleic acid (0.06 ml/kg) pulmonary edema. Gas exchange was assessed at constant ventilation and constant cardiac output, by venous admixture calculations and by intrapulmonary shunt measurements using the sulfur hexafluoride (SF6) method. Metabolic acidosis (pH 7.20) and alkalosis (pH 7.60) were induced with HCl and Carbicarb (isosmolar Na2CO3 and NaHCO3), respectively. Hypercapnia was induced by adding inspiratory CO2, whereas pH was allowed to change (respiratory acidosis, pH 7.20) or maintained constant (isolated hypercapnia). Mean intrapulmonary shunt and pulmonary arterial minus wedge pressure difference, respectively, changed from 44 to 33% (P less than 0.05) and from 9 to 10 mmHg (P greater than 0.05) in metabolic acidosis, from 44 to 62% (P less than 0.001) and from 12 to 8 mmHg (P less than 0.01) in metabolic alkalosis, from 40 to 42% (P greater than 0.05) and from 13 to 16 mmHg (P less than 0.05) in respiratory acidosis, from 42 to 52% (P less than 0.05) and from 8 to 12 mmHg (P less than 0.01) in isolated hypercapnia. These results indicate that acidosis, alkalosis, and hypercapnia markedly influence pulmonary gas exchange and/or pulmonary hemodynamics in dogs with oleic acid pulmonary edema.

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Rebreathing lung tissue volume of sheep with normal and edematous lungs

Journal of Applied Physiology ◽

10.1152/jappl.1986.61.3.1132 ◽

1986 ◽

Vol 61 (3) ◽

pp. 1132-1138 ◽

Cited By ~ 2

Author(s):

G. J. Huchon ◽

A. Lipavsky ◽

J. M. Hoeffel ◽

J. F. Murray

Keyword(s):

Oleic Acid ◽

Pulmonary Edema ◽

Blood Volume ◽

Lung Tissue ◽

Extravascular Lung Water ◽

Lung Water ◽

Lung Weight ◽

Tissue Volume ◽

Accuracy Of Measurements ◽

Permeability Pulmonary Edema

To determine the accuracy of measurements of lung tissue volume (Vlt) by rebreathing acetylene in normal and edematous lungs, we compared gravimetric values of total lung weight (Ql) and extravascular lung water (Qwl) with Vlt in anesthetized control sheep (C) and sheep with hydrostatic pulmonary edema (HPE) or oleic acid-induced permeability pulmonary edema (PPE), five animals each. In eight additional sheep we determined that acetylene solubility in blood (0.117 +/- 0.010 ml X 100 ml-1 X Torr-1) differed significantly from that in lung-blood homogenates (0.095 +/- 0.009 ml X 100 ml-1 X Torr-1, P = 0.0017). The latter value was used in all calculations. In C, Vlt was 194% of Qwl and 98% of Ql; in HPE, Vlt was 144% of Qwl and 87% of Ql; and in PPE, Vlt was 112% of Qwl and 77% of Ql. We conclude that when the lungs are normal, Vlt reasonably measures Ql not Qwl. However in both HPE and PPE, Vlt progressively underestimates Ql and cannot differentiate between increased blood volume and increased Qwl.

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