The ubiquitin ligase Nedd4-2 is a potent regulator of the voltage-gated sodium channel Nav1.7 and is implicated in neuropathic pain

2011 ◽  
Vol 28 ◽  
pp. 2
Author(s):  
C. Laedermann ◽  
M. Cachemaille ◽  
H. Abriel ◽  
I. Decosterd
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Ubiquitin Ligase ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

scholarly journals DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain

2017 ◽  
Vol 38 (5) ◽  
pp. 1124-1136 ◽  
Author(s):  
Yan Li ◽  
Robert Y. North ◽  
Laurence D. Rhines ◽  
Claudio Esteves Tatsui ◽  
Ganesh Rao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

scholarly journals Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

2013 ◽  
Vol 118 (1) ◽  
pp. 160-172 ◽  
Author(s):  
Marc R. Suter ◽  
Guylène Kirschmann ◽  
Cedric J. Laedermann ◽  
Hugues Abriel ◽  
Isabelle Decosterd
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Mechanical Allodynia ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats

2017 ◽  
Vol 153 ◽  
pp. 116-129 ◽  
Author(s):  
Jee Youn Lee ◽  
Yoo Lim Kam ◽  
Jungae Oh ◽  
Dong Hyun Kim ◽  
Jin-Sung Choi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Channel Blocker ◽  
Sodium Channel Blocker ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

scholarly journals Nedd4-2 (NEDD4L) controls intracellular Na+-mediated activity of voltage-gated sodium channels in primary cortical neurons

2013 ◽  
Vol 457 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Jenny A. Ekberg ◽  
Natasha A. Boase ◽  
Grigori Rychkov ◽  
Jantina Manning ◽  
Philip Poronnik ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sodium Channels ◽  
Ubiquitin Ligase ◽  
Cortical Neurons ◽  
Channel Activity ◽  
Primary Cortical Neurons ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
First Time

The study shows for the first time that the ubiquitin ligase Nedd4-2 regulates voltage-gated sodium channel activity in cortical neurons, specifically in response to elevated intracellular Na+ concentration.

Sign in / Sign up

Export Citation Format

Share Document