Use of Drotrecogin Alpha in a surgical cohort of intra-abodominal infections patients

2011 ◽  
Vol 28 ◽  
pp. 182 ◽  
Author(s):  
E. Sanchez-García ◽  
J. A. Navarro-Martinez ◽  
A. Idrissi ◽  
E. Paya ◽  
N. Nicolas ◽  
...  
Keyword(s):  
Drotrecogin Alpha

scholarly journals Effects of vacuum-assisted closure and Drotrecogin alpha on inflammatory markers in severe acute pancreatitis

2013 ◽  
Vol 04 (08) ◽  
pp. 43-53
Author(s):  
Oscar Arias-Carvajal ◽  
José Manuel Hermosillo-Sandoval ◽  
Carlos Alberto Gutiérrez-Martínez ◽  
Fermín Paul Pacheco-Moisés ◽  
Genaro Gabriel Ortiz ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Inflammatory Markers ◽  
Vacuum Assisted Closure ◽  
Drotrecogin Alpha

scholarly journals Drotrecogin Alpha (Activated) in Two Patients with the Hantavirus Cardiopulmonary Syndrome

2006 ◽  
Vol 13 (5) ◽  
pp. 272-274 ◽  
Author(s):  
Robert C McDermid ◽  
RT Noel Gibney ◽  
Ronald J Brisebois ◽  
Neil M Skjodt
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Definitive Diagnosis ◽  
Endothelial Injury ◽  
Capillary Leak ◽  
Hypoxemic Respiratory Failure ◽  
Vasoactive Medications ◽  
Drotrecogin Alpha

Hantavirus cardiopulmonary syndrome (HCPS) is associated with rapid cardiopulmonary collapse from endothelial injury, resulting in massive capillary leak, shock and severe hypoxemic respiratory failure. To date, treatment remains supportive and includes mechanical ventilation, vasopressors and extracorporeal membrane oxygenation, with mortality approaching 50%. Two HCPS survivors initially given drotrecogin alpha (activated) (DAA) for presumed bacterial septic shock are described. Vasoactive medications were required for a maximum of 52 h, whereas creatinine levels and platelet counts normalized within seven to nine days. Given the similar presentations of HCPS and bacterial septic shock, empirical DAA therapy will likely be initiated before a definitive diagnosis of HCPS is made. Further observations of DAA in HCPS seem warranted.

EVALUATION OF THE USE OF DROTRECOGIN ALPHA (ACTIVATED) IN ADULT SEVERE SEPSIS AT THE OTTAWA HOSPITAL

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A155
Author(s):  
Julie Kim ◽  
Salmaan Kanji ◽  
Michael Tierney ◽  
Kevin McDonald ◽  
Avinder Singh ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Ottawa Hospital ◽  
Drotrecogin Alpha

Drotrecogin alpha (activated) in neonatal septic shock

2005 ◽  
Vol 37 (4) ◽  
pp. 306-308 ◽  
Author(s):  
David Frommhold ◽  
Alexandra Birle ◽  
Otwin Linderkamp ◽  
Eugen P. Zilow ◽  
Johannes M.B. Pöschl
Keyword(s):  
Septic Shock ◽  
Drotrecogin Alpha

Drotrecogin alpha (activated)

2003 ◽  
Vol 2 (1) ◽  
pp. 13-14 ◽  
Author(s):  
John Lebbos ◽  
Julia Bradsher ◽  
Peter Kirkpatrick
Keyword(s):  
Drotrecogin Alpha

scholarly journals Titrated dose of drotrecogin alpha for liver transplant recipient

2012 ◽  
Vol 58 (4) ◽  
pp. 330
Author(s):  
CK Pandey ◽  
A Singhal ◽  
V Saluja ◽  
V Pandey
Keyword(s):  
Transplant Recipient ◽  
Liver Transplant ◽  
Liver Transplant Recipient ◽  
Drotrecogin Alpha

scholarly journals Interleukin-10 gene down-expression in circulating mononuclear cells during infusion of drotrecogin-alpha activated: a pilot study

Critical Care ◽  
2010 ◽  
Vol 14 (5) ◽  
pp. R163 ◽  
Author(s):  
Thomas Lavaux ◽  
Pascal Bilbault ◽  
Anne Launoy ◽  
Marie-Pierre Gaub ◽  
Pierre Oudet ◽  
...  
Keyword(s):  
Pilot Study ◽  
Mononuclear Cells ◽  
Interleukin 10 ◽  
Drotrecogin Alpha

THREE YEAR EXPERIENCE WITH A DROTRECOGIN-ALPHA PROTOCOL FOR SEVERE SEPSIS: ANALYSIS OF USE, COST, AND MORBIDITY IN A UNIVERSITY HOSPITAL

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 302S
Author(s):  
Sonja D. Bartolome ◽  
Steven Q. Simpson ◽  
Steve Flaherty ◽  
Amy R. O’Brien-Ladner ◽  
Timothy Dwyer ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
University Hospital ◽  
Drotrecogin Alpha
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