REM Sleep Behavior Disorder: Potential Relationship to Post-traumatic Stress Disorder

2001 ◽  
Vol 18 (2) ◽  
pp. 148-157 ◽  
Author(s):  
Aatif M. Husain ◽  
Patricia P. Miller ◽  
Sandra T. Carwile
Keyword(s):  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Post Traumatic ◽  
Disorder Potential

Abnormal REM Sleep Atonia Control in Chronic Post-Traumatic Stress Disorder

SLEEP ◽  
2021 ◽  
Author(s):  
John C Feemster ◽  
Tyler A Steele ◽  
Kyle P Palermo ◽  
Christy L Ralston ◽  
Yumeng Tao ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Sleep Disturbances ◽  
Stress Disorder ◽  
Rem Sleep Behavior Disorder ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Chronic Ptsd ◽  
Post Traumatic

Abstract Study Objectives Post-traumatic stress disorder (PTSD) and REM sleep behavior disorder (RBD) share some common features including prominent nightmares and sleep disturbances. We aimed to comparatively analyze REM sleep without atonia (RSWA) between patients with chronic PTSD with and without dream enactment behavior (DEB), isolated RBD (iRBD), and controls. Methods In this retrospective study, we comparatively analyzed 18 PTSD with DEB (PTSD+DEB), 18 PTSD without DEB, 15 iRBD, and 51 controls matched for age and sex. We reviewed medical records to determine PTSD clinical features and quantitatively analyzed RSWA. We used non-parametric analyses to compare clinical and polysomnographic features. Results PTSD patients, both with and without DEB, had significantly higher RSWA than controls (all p < 0.025, excepting submentalis phasic duration in PTSD+DEB). Most RSWA measures were also higher in PTSD+DEB than in PTSD without DEB patients (all p <0.025). Conclusions PTSD patients have higher RSWA than controls, whether DEB is present or not, indicating that REM sleep atonia control is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients.

scholarly journals 0817 Abnormal REM Sleep Atonia Control In Patients With Chronic Post-traumatic Stress Disorder

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A310-A312
Author(s):  
J Feemster ◽  
T Steele ◽  
Y Tao ◽  
S Rivera ◽  
T Gossard ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Rem Sleep Behavior Disorder ◽  
Psychiatric Disease ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Unique Biology ◽  
Post Traumatic

Abstract Introduction Post-traumatic stress disorder (PTSD) is characterized by persistent mental and emotional stress following one or more significant physical or psychological traumatic incidents earlier in life. Vivid recall of the events, including traumatic nightmares, and prominent sleep disturbance are usual in PTSD. Previous studies have suggested that PTSD may share some clinical features with idiopathic REM sleep behavior disorder (iRBD) including altered REM sleep without atonia (RSWA) levels. Our group has previously found evidence for altered RSWA control in patients with psychiatric disease, including a pilot sample of PTSD patients with iRBD. We aimed to comparatively analyze RSWA levels between patients with PTSD, PTSD and RBD (PTSD+RBD), iRBD, and controls. Methods We selected 18 PTSD, 18 PTSD+RBD, 15 iRBD, and 51 healthy control patients matched for age and sex from the Mayo Clinic Center for Sleep Medicine’s polysomnography database for RSWA quantification. RSWA amounts in the submentalis (SM) and anterior tibialis (AT) were quantitatively analyzed as a percentage of REM sleep duration, in accordance with previously published methods. Non-parametric analyses were performed to compare RSWA, patient demographics, and PSG data across groups. Significance was set at p < 0.016. Results Patients with PTSD had significantly higher RSWA than controls in all RSWA density measures (p < 0.016 for all). All measures of RSWA, excluding average SM duration, were significantly greater in PTSD+RBD patients compared with controls (p < 0.016 for all). Within the PTSD group, patients on antidepressants did not have significantly higher RSWA in any of the measures. PTSD+RBD patients had significantly higher SM Phasic, AT Any, SM+AT Any, and Tonic RSWA measures than PTSD patients (p < 0.016 for all). Conclusion PTSD patients have significantly higher RSWA than controls, with PTSD+RBD patients having higher RSWA levels than PTSD patients. These data provide the first evidence for abnormal RSWA control in patients with chronic PTSD. This provides evidence of a unique biology in PTSD that could imply a future risk for neurodegenerative disease in PTSD similar to RBD patients. Further prospective studying will need to be performed on patients with PTSD to understand the unique biology. Support  

scholarly journals REM Sleep Behavior Disorder among Veterans with and without Post-Traumatic Stress Disorder

2020 ◽  
Vol 17 (10) ◽  
pp. 987-995
Author(s):  
EunYoung Lee ◽  
Kiwon Kim ◽  
Hyung Seok So ◽  
Jin Hee Choi ◽  
In-Young Yoon ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Behavior Disorder ◽  
Exposed Group ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Male Age ◽  
Post Traumatic

Objective Among veterans, the prevalence of rapid eye movement sleep behavior disorder (RBD) is higher than among the general population, and some evidence suggests that this is related to post-traumatic stress disorder (PTSD). The purpose of this study was to determine whether the frequency of RBD differs depending on the presence of PTSD or trauma.Methods Patients who underwent nocturnal polysomnography (PSG) and sleep-related questionnaire surveys at the Veteran Health Service Medical Center were reviewed retrospectively. Based on patients with PTSD (n=20; 100% male; 67.9±8.5 years of age), we matched patients exposed to trauma without PTSD (n23; 100% male; age 64.0±13.4) and patients without trauma (n=21; 100% male; age 59.86±10.9).Results PTSD patients reported dream enactment behavior more than the trauma-exposed group without PTSD or the control group (p=0.006). After adjusting for age, there were more RBD patients in the PTSD group than in the trauma exposed group (p=0.049).Conclusion The results showed that RBD occurred significantly more in veterans with PTSD than those exposed to trauma, which suggests that there may be a pathophysiological association between PTSD and RBD.

scholarly journals The spectral fingerprint of sleep problems in post-traumatic stress disorder

SLEEP ◽  
2019 ◽  
Vol 43 (4) ◽  
Author(s):  
M de Boer ◽  
M J Nijdam ◽  
R A Jongedijk ◽  
K A Bangel ◽  
M Olff ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Sleep Problems ◽  
Nrem Sleep ◽  
Post Traumatic Stress ◽  
Oscillation Power ◽  
Post Traumatic

Abstract Study Objectives Sleep problems are a core feature of post-traumatic stress disorder (PTSD). The aim of this study was to find a robust objective measure for the sleep disturbance in patients having PTSD. Methods The current study assessed EEG power across a wide frequency range and multiple scalp locations, in matched trauma-exposed individuals with and without PTSD, during rapid eye movement (REM) and non-REM (NREM) sleep. In addition, a full polysomnographical evaluation was performed, including sleep staging and assessment of respiratory function, limb movements, and heart rate. The occurrence of sleep disorders was also assessed. Results In patients having PTSD, NREM sleep shows a substantial loss of slow oscillation power and increased higher frequency activity compared with controls. The change is most pronounced over right-frontal sensors and correlates with insomnia. PTSD REM sleep shows a large power shift in the opposite direction, with increased slow oscillation power over occipital areas, which is strongly related to nightmare activity and to a lesser extent with insomnia. These pronounced spectral changes occur in the context of severe subjective sleep problems, increased occurrence of various sleep disorders and modest changes in sleep macrostructure. Conclusions This is the first study to show pronounced changes in EEG spectral topologies during both NREM and REM sleep in PTSD. Importantly, the observed power changes reflect the hallmarks of PTSD sleep problems: insomnia and nightmares and may thus be specific for PTSD. A spectral index derived from these data distinguishes patients from controls with high effect size, bearing promise as a candidate biomarker.

scholarly journals Mental and Physical Factors Influencing Wellbeing among South Korean Emergency Workers

2020 ◽  
Vol 18 (1) ◽  
pp. 70
Author(s):  
Mi Young Choi
Keyword(s):  
Sleep Quality ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
South Korean ◽  
Emergency Workers ◽  
Post Traumatic

Emergency workers are frequently exposed to hazardous situations and such life patterns can influence their wellbeing. This study examined the relationships among South Korean emergency workers’ precedents and consequences of positive emotion, engagement, relationship, meaning, and achievement (PERMA), a wellbeing concept, and offered solutions. A total of 597 emergency workers in Daegu, South Korea, participated in a survey. This study measured post-traumatic stress disorder syndrome, burnout, depression, PERMA, quality of life, life satisfaction, and sleep quality to test the relationships. Results demonstrated that post-traumatic stress disorder syndrome and burnout predicted distracting sleep behavior and sleep health. Depression was significantly related to PERMA. The better the emergency workers’ PERMA was, the better their quality of life and life satisfaction were. PERMA significantly predicted sleep behavior, a portion of sleep quality. Depression had an indirect influence on quality of life mediated by PERMA. Post-traumatic stress disorder syndrome, burnout, and PERMA were significant predictors of low sleep health and sleep behavior. The results indicate that South Korean emergency workers struggle with depression and sleep quality. As the data were collected during the coronavirus disease 19 pandemic, individual efforts and relevant programs to improve South Korean emergency workers’ PERMA and sleep quality in a crisis are recommended. Possible solutions to improve the wellbeing of South Korean emergency workers are suggested.

scholarly journals The Spectral Fingerprint of Sleep Problems in Post-Traumatic Stress Disorder

2017 ◽  
Author(s):  
M. de Boer ◽  
M.J. Nijdam ◽  
R.A. Jongedijk ◽  
Olff ◽  
W.F. M. Hofman ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Sleep Problems ◽  
Nrem Sleep ◽  
Post Traumatic Stress ◽  
Oscillation Power ◽  
Post Traumatic

AbstractBACKGROUNDSleep problems are a core feature of post-traumatic stress disorder (PTSD). However, a robust objective measure for the sleep disturbance in patients has yet to be found.METHODSThe current study assessed EEG power across a wide frequency range and multiple scalp locations, in matched trauma-exposed individuals with and without PTSD, during rapid eye movement (REM) and non-REM (NREM) sleep. In addition, a full polysomnographical evaluation was performed, including sleep staging and assessment of respiratory function, limb movements and heart rate. The occurrence of sleep disorders was also assessed.RESULTSIn PTSD patients, NREM sleep shows a substantial loss of slow oscillation power and increased higher frequency activity compared to controls. The change is most pronounced in right-frontal brain areas and correlates with insomnia. PTSD REM sleep shows a large power shift in the opposite direction, with increased slow oscillation power in occipital areas, which is strongly related to nightmare activity and to lesser extent with insomnia. These pronounced spectral changes occur in the context of severe subjective sleep problems, increased occurrence of various sleep disorders and modest changes in sleep macrostructure.CONCLUSIONSThis is the first study to show pronounced changes in EEG spectral topologies during both NREM and REM sleep in PTSD. Importantly, the observed power changes reflect the hallmarks of PTSD sleep problems: insomnia and nightmares and may thus be specific for PTSD. A spectral index derived from these data distinguishes patients from controls with high effect size, bearing promise as a candidate biomarker.

scholarly journals REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder

2020 ◽  
Vol 11 (1) ◽  
pp. 1740492 ◽  
Author(s):  
Dimitris Repantis ◽  
Katharina Wermuth ◽  
Nikolaos Tsamitros ◽  
Heidi Danker-Hopfe ◽  
Jan Christoph Bublitz ◽  
...  
Keyword(s):  
Secondary Prevention ◽  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

scholarly journals Alterations in sleep electroencephalography synchrony in combat-exposed veterans with post-traumatic stress disorder

SLEEP ◽  
2020 ◽  
Vol 43 (7) ◽  
Author(s):  
Srinivas Laxminarayan ◽  
Chao Wang ◽  
Sridhar Ramakrishnan ◽  
Tatsuya Oyama ◽  
J David Cashmere ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Sleep Stage ◽  
Brain Regions ◽  
Sleep Stages ◽  
Alpha Band ◽  
Post Traumatic Stress ◽  
Post Traumatic

Abstract Study Objectives We assessed whether the synchrony between brain regions, analyzed using electroencephalography (EEG) signals recorded during sleep, is altered in subjects with post-traumatic stress disorder (PTSD) and whether the results are reproducible across consecutive nights and subpopulations of the study. Methods A total of 78 combat-exposed veteran men with (n = 31) and without (n = 47) PTSD completed two consecutive laboratory nights of high-density EEG recordings. We computed a measure of synchrony for each EEG channel-pair across three sleep stages (rapid eye movement [REM] and non-REM stages 2 and 3) and six frequency bands. We examined the median synchrony in 9 region-of-interest (ROI) pairs consisting of 6 bilateral brain regions (left and right frontal, central, and parietal regions) for 10 frequency-band and sleep-stage combinations. To assess reproducibility, we used the first 47 consecutive subjects (18 with PTSD) for initial discovery and the remaining 31 subjects (13 with PTSD) for replication. Results In the discovery analysis, five alpha-band synchrony pairs during non-REM sleep were consistently larger in PTSD subjects compared with controls (effect sizes ranging from 0.52 to 1.44) across consecutive nights: two between the left-frontal and left-parietal ROIs, one between the left-central and left-parietal ROIs, and two across central and parietal bilateral ROIs. These trends were preserved in the replication set. Conclusion PTSD subjects showed increased alpha-band synchrony during non-REM sleep in the left frontoparietal, left centro-parietal, and inter-parietal brain regions. Importantly, these trends were reproducible across consecutive nights and subpopulations. Thus, these alterations in alpha synchrony may be discriminatory of PTSD.

Sign in / Sign up

Export Citation Format

Share Document