scholarly journals REM Sleep Behavior Disorder among Veterans with and without Post-Traumatic Stress Disorder

2020 ◽  
Vol 17 (10) ◽  
pp. 987-995
Author(s):  
EunYoung Lee ◽  
Kiwon Kim ◽  
Hyung Seok So ◽  
Jin Hee Choi ◽  
In-Young Yoon ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Behavior Disorder ◽  
Exposed Group ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Male Age ◽  
Post Traumatic

Objective Among veterans, the prevalence of rapid eye movement sleep behavior disorder (RBD) is higher than among the general population, and some evidence suggests that this is related to post-traumatic stress disorder (PTSD). The purpose of this study was to determine whether the frequency of RBD differs depending on the presence of PTSD or trauma.Methods Patients who underwent nocturnal polysomnography (PSG) and sleep-related questionnaire surveys at the Veteran Health Service Medical Center were reviewed retrospectively. Based on patients with PTSD (n=20; 100% male; 67.9±8.5 years of age), we matched patients exposed to trauma without PTSD (n23; 100% male; age 64.0±13.4) and patients without trauma (n=21; 100% male; age 59.86±10.9).Results PTSD patients reported dream enactment behavior more than the trauma-exposed group without PTSD or the control group (p=0.006). After adjusting for age, there were more RBD patients in the PTSD group than in the trauma exposed group (p=0.049).Conclusion The results showed that RBD occurred significantly more in veterans with PTSD than those exposed to trauma, which suggests that there may be a pathophysiological association between PTSD and RBD.

Changes of 5-HT1A receptor in the dorsal raphe nucleus in the rat model of Post-Traumatic Stress Disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 1081-1081
Author(s):  
F.F. Luo ◽  
F. Han ◽  
X.Y. Shi
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Dorsal Raphé

IntroductionPosttraumatic stress disorder (PTSD) is characterized mainly by symptoms of reexperiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The dorsal raphe nucleus (DR)-serotonin (5-HT) system is dramatically affected by swim stress and has been implicated in affective disorders. The 5-HT1A receptor (5-HT1AR) is critically involved in regulating mood and anxiety levels.ObjectiveIn this study, we investigated changes in the expression of 5-HT1AR in DR of rats after SPS which may reveal part of the pathogenesis of PTSD.MethodsRats were randomly divided into 24h, 4d and 7d groups after SPS and a normal control group, 5-HT1AR expression in DR was examined using immunohistochemistry, western blotting and reverse transcription polymerase chain reaction.ResultsThe expression of 5-HT1AR in DR after SPS exposure was increased when compared to that in the control group (P < 0.05).ConclusionThese findings suggest increase of 5-HT1AR in DR of SPS rats, which may play important roles in the pathogenesis of PTSD rats.

scholarly journals Evaluation of secondary post-traumatic stress disorder symptoms in the spouses of chemical warfare victims 20 years after the Iran–Iraq war

2011 ◽  
Vol 35 (5) ◽  
pp. 168-175 ◽  
Author(s):  
Khodabakhsh Ahmadi ◽  
Mahmood Reshadatjoo ◽  
GholamReza Karami ◽  
Nariman Sepehrvand ◽  
Pegah Ahmadi ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Chemical Warfare ◽  
Control Group ◽  
Case Group ◽  
Ptsd Symptoms ◽  
Post Traumatic Stress ◽  
Study Results ◽  
Post Traumatic

Aims and methodPost-traumatic stress disorder (PTSD) has been reported in 90% of chemical warfare victims in previous studies. An individual's traumatic experience(s) may affect the lives of other family members as well. This cross-sectional case–control study compared the prevalence of PTSD symptoms in the husbands, the secondary PTSD symptoms in the wives and also aimed to identify if there was an association between the PTSD symptoms of the couples in the case group. Cases were 150 husband–wife couples where husbands were civilians exposed to chemical warfare; the controls were 156 husband–wife couples where there was no such exposure. Both cases and controls were recruited from Sardasht in Iran; this Kurdish city was attacked by four 250 kg sulphur mustard warheads in June 1987.ResultsAcross three sets of cut-off points for the Mississippi Scale for Combat-Related PTSD symptomotology (<120 and ⩾121; <106 and ⩾107; and <65, 65–130 and > 130) wives in the case group demonstrated higher rates of PTSD symptoms than did those in the control group; the difference was statistically significant. Furthermore, husbands in the case group had a significantly higher overall mean score (123.0 (s.d. = 17.2)) than the husbands in the control group (112.3 (s.d. = 21.7); P<0.001, t = 4.80). There was no statistically significant association between the overall PTSD score of the husbands in the case group with that of their wives (P = 0.274, correlation coefficient 0.092).Clinical implicationsHusbands who were exposed to the chemical agents reported higher PTSD symptoms and there were higher rates of PTSD symptoms among the wives of individuals who were exposed to chemical warfare. Study results suggest the need for coordinated treatments, policy efforts and interventions to improve the wellbeing of chemical warfare victims and their caregiver wives.

scholarly journals Intrinsic Network Brain Dysfunction Correlates With Temporal Complexity in Post-traumatic Stress Disorder

2021 ◽  
Author(s):  
Yingliang Dai ◽  
Zhou Zhou ◽  
Feng Chen ◽  
Li Zhang ◽  
Jun Ke ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Dynamic Properties ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Emotional Modulation ◽  
Whole Brain ◽  
Brain Level ◽  
Post Traumatic

Abstract BackgroundResearch has been looking into neural pathophysiology of post-traumatic stress disorder (PTSD) and dynamic functioning connectivity (dFC) applying resting state functional magnetic resonance imaging (rs-fMRI). Previous studies showed that PTSD related impairments are associated with alterations distributed across different brain regions and disorganized functional connectivity, especially in Default Mode Network and the cerebellar area. In this study, we specifically looked into dFC on a whole brain level, and we focused on critical regions such as DMN and cerebellum. MethodsTo explore the characteristics of dFC among patients with PTSD, we collected rs-fMRI data from 27 PTSD patients and 30 healthy controls. The study also added a control group of 33 trauma-exposed individuals to further look into trauma impact. Utilizing group spatial independent component analysis (ICA), the dynamic properties on whole brain level were detected with sliding time window approach, and k-means clustering. ResultsTwo reoccurring FC “States” were identified, with connections being more concentrated on a within-network level in one state and more strongly inter-connected in the other state. Abnormalities in dFC were found within DMN, between DMN and cerebellum, and between DMN and visual network. ConclusionsThe findings were in accordance with the study hypothesis that PTSD patients demonstrated deficits in emotional modulation and dysfunctional self-referential thoughts, and the deficits could be indicated in dFC alterations. Abnormalities in dFC among PTSD patients could serve as appropriate indicators of PTSD symptoms including depression and anxiety, hypervigilance, as well as impaired cognitive functioning and self-referential information processing.

scholarly journals Identification of DNA Methylation Changes That Predict Onset of Post-traumatic Stress Disorder and Depression Following Physical Trauma

2021 ◽  
Vol 15 ◽  
Author(s):  
Carina A. Martin ◽  
Rany Vorn ◽  
Martin Schrieber ◽  
Chen Lai ◽  
Sijung Yun ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Stressful Events ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Physical Trauma ◽  
Post Traumatic ◽  
And Control

Post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly experienced after exposure to highly stressful events, including physical trauma, yet, biological predictors remain elusive. Methylation of DNA may provide key insights, as it likely is reflective of factors that may increase the risk in trauma patients, as DNA methylation is altered by previous stressors. Here, we compared DNA methylation patterns using bisulfite sequencing in patients with a physical trauma that required more than a 24-h hospitalization (n = 33). We then compared DNA methylation in patients who developed and compared the following groups (1) PTSD and MDD; n = 12), (2) MDD (patients with MDD only; n = 12), and (3) control (patients who did not have PTSD or MDD; n = 9), determined by the PTSD Checklist (PCL-5) and Quick Inventory of Depressive Symptomatology (QIDS) at 6-months follow-up. We identified 17 genes with hypermethylated cytosine sites and 2 genes with hypomethylated sites in comparison between PTSD and control group. In comparison between MDD and control group, we identified 12 genes with hypermethylated cytosine sites and 6 genes with hypomethylated sites. Demethylation of these genes altered the CREB signaling pathway in neurons and may represent a promising therapeutic development target for PTSD and MDD. Our findings suggest that epigenetic changes in these gene regions potentially relate to the onset and symptomology of PTSD and MDD and could be used as potential biomarkers in predicting the onset of PTSD or MDD following traumatic events.

scholarly journals Mental and Physical Factors Influencing Wellbeing among South Korean Emergency Workers

2020 ◽  
Vol 18 (1) ◽  
pp. 70
Author(s):  
Mi Young Choi
Keyword(s):  
Sleep Quality ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
South Korean ◽  
Emergency Workers ◽  
Post Traumatic

Emergency workers are frequently exposed to hazardous situations and such life patterns can influence their wellbeing. This study examined the relationships among South Korean emergency workers’ precedents and consequences of positive emotion, engagement, relationship, meaning, and achievement (PERMA), a wellbeing concept, and offered solutions. A total of 597 emergency workers in Daegu, South Korea, participated in a survey. This study measured post-traumatic stress disorder syndrome, burnout, depression, PERMA, quality of life, life satisfaction, and sleep quality to test the relationships. Results demonstrated that post-traumatic stress disorder syndrome and burnout predicted distracting sleep behavior and sleep health. Depression was significantly related to PERMA. The better the emergency workers’ PERMA was, the better their quality of life and life satisfaction were. PERMA significantly predicted sleep behavior, a portion of sleep quality. Depression had an indirect influence on quality of life mediated by PERMA. Post-traumatic stress disorder syndrome, burnout, and PERMA were significant predictors of low sleep health and sleep behavior. The results indicate that South Korean emergency workers struggle with depression and sleep quality. As the data were collected during the coronavirus disease 19 pandemic, individual efforts and relevant programs to improve South Korean emergency workers’ PERMA and sleep quality in a crisis are recommended. Possible solutions to improve the wellbeing of South Korean emergency workers are suggested.

scholarly journals The Effectiveness of Music on Quality of Life and Anxiety Symptoms in the Post Traumatic Stress Disorder in Bustan Hospital of Ahvaz City

2016 ◽  
Vol 8 (3) ◽  
pp. 237
Author(s):  
Ebtesam Jasemi Zergani ◽  
Farah Naderi
Keyword(s):  
Quality Of Life ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Anxiety Symptoms ◽  
Stress Disorders ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Post Traumatic

<p>The present study aims at investigating the effectiveness of music on quality of life and anxiety symptoms of the veterans with post traumatic stress disorder in Bustan hospital of Ahvaz City. 40 persons were selected by simple random sampling method from the aforementioned population. The research design was an experimental one of type pretest-posttest with control group. Quality of Life inventory SF-36 (2005) and Spielberger Anxiety inventory (2005) were used for collecting the data. After selecting groups randomly, pretest was implemented on both experiment group (20 persons) and control group (20 persons). Then, music therapy intervention was implemented on the experiment group during 20 sessions each of which with 45 minutes. At the end of subject program, both groups were given posttest. Data were analyzed by using the multivariate covariance analysis. Results showed that presenting music can affect quality of life and anxiety symptoms of the veterans with posttraumatic stress disorders and this effect remained stable after one month of follow-up. Therefore, presenting music can be effective in treating the veterans with stress disorders after the accident.</p>

Post-traumatic stress symptoms linked to hidden Holocaust trauma among adult Finnish evacuees separated from their parents as children in World War II, 1939–1945: a case-control study

2010 ◽  
Vol 23 (4) ◽  
pp. 654-661 ◽  
Author(s):  
Pentti Andersson
Keyword(s):  
World War Ii ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Test Group ◽  
Control Group ◽  
Long Term Effects ◽  
Post Traumatic Stress ◽  
World War ◽  
Post Traumatic

ABSTRACTBackground: The aim of this study was to identify long-term effects of diagnostic criteria on the Post Traumatic Stress Disorder Checklist (PCL-C) for a test group of Finnish evacuees from World War II and compare the outcome effect with a control group of children who lived in Finland during the war in 1939–1945.Methods: 152 participants were recruited by the local leader of the Finnish War Child Association in Sweden and Finland. The selected group answered questions on the Post Traumatic Stress Disorder Checklist (PCL-C) and the EMBU (Swedish acronym for “Own Memories of Parental Rearing”).Results: Evidence suggests a link between childhood parental separation and termination of the internalized attachment hierarchy of origin in a detachment process among Finnish evacuees. Based on the Post Traumatic Stress Disorder Total (PCL-C) diagnosis an extreme traumatization for 36.7% of the test group subjects was identified, including a hidden Holocaust trauma in the population of Finnish evacuees.Conclusions: The study met the criteria for satisfying global evidence value. Sixty-five years after the end of World War II and in line with other studies on war children, the data show high levels of different trauma exposures from the war with 10.6 higher risk (odds ratio) for the exposed group of Finnish evacuees. Despite some limitations, the data highlight the need for further investigation into different parts of the detachment process among seriously traumatized groups to reveal resilience and other dimensions of importance in professional mental health creation.

scholarly journals Effect of Psychodrama on Post-traumatic Stress Disorder Symptoms in Primary School Students Living in Earthquake-stricken Areas

2021 ◽  
Vol 26 (4) ◽  
pp. 400-417
Author(s):  
Farideh Hamidi ◽  
◽  
Shoaib Sobhani Tabar ◽  
Keyword(s):  
Primary School ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Primary School Students ◽  
School Students ◽  
Post Traumatic

Objectives: This study aims to determine the effectiveness of psychodrama in reducing the symptoms of Post-Traumatic Stress Disorder (PTSD) in primary school students living in earthquake-stricken areas. Methods: This is a quasi-experimental study with pre-test/post-test design using a control group. The study population consists of all male primary school students diagnosed with PTSD living in Salas-e Babajani County, Kermanshah, Iran. Of these, 40 were selected using a purposive sampling method and based on the PTSD criteria, and were then divided into two groups of intervention (n=20) and control (n=20). Research instruments were a diagnostic interview based on Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria and the PTSD Checklist for DSM5 (PCL-5) questionnaire. Data were analyzed using one-way and multivariate analysis of covariance. Results: Psychodrama reduced the symptoms of PTSD in children with an effect size of 0.51 (P<0.001). Conclusion: Psychodrama is an effective method for reducing the PTSD symptoms and neuropsychological problems. For the generalization of its results, further studies are recommended.

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