Studies on the Natriuretic Effect of Nifedipine in Hypertensive Patients: Increase in Levels of Plasma Atrial Natriuretic Factor Without Participation of the Renal Kallikrein-Kinin System

1987 ◽  
Vol 5 (Supplement 4) ◽  
pp. S61-S65 ◽  
Author(s):  
Alessandro Rappelli ◽  
Paolo Dessi-Fulgheri ◽  
Paolo Madeddu ◽  
Nicola Glorioso
Keyword(s):  
Atrial Natriuretic Factor ◽  
Kinin System ◽  
Hypertensive Patients ◽  
Natriuretic Factor ◽  
Renal Kallikrein ◽  
Natriuretic Effect ◽  
Kallikrein Kinin System ◽  
Atrial Natriuretic

Renal and endocrine effects of physiological variations of atrial natriuretic factor in normal humans

1991 ◽  
Vol 260 (1) ◽  
pp. R217-R224 ◽  
Author(s):  
N. E. Bruun ◽  
P. Skott ◽  
J. Giese
Keyword(s):  
Atrial Natriuretic Factor ◽  
Plasma Concentrations ◽  
Normal Subjects ◽  
Endocrine Effects ◽  
Renin Substrate ◽  
Fluid Delivery ◽  
Natriuretic Factor ◽  
51Cr Edta ◽  
Natriuretic Effect ◽  
Atrial Natriuretic

The renal and endocrine effects of incremental infusions of 3 and 6 ng.kg-1.min-1 of exogenous atrial natriuretic factor (ANF)-(99-126) or placebo were investigated in 10 normal subjects. A 90-min basal period was followed by two 2-h infusion periods with urine collection in the last 90 min of each period. Plasma ANF concentration increased by 50 and 150%, respectively, from a basal value of 6.2 +/- 3.1 pmol/l. Plasma guanosine 3',5'-cyclic monophosphate concentration increased in parallel with ANF. Blood pressure and heart rate were unchanged, whereas hematocrit was stepwise increased. 51Cr-EDTA clearance (GFR) did not change, but ANF caused an increase in Li clearance (a measure of end-proximal fluid delivery), Na clearance, and urine flow compared with time-matched control values. These excretory effects of ANF were mainly due to prevention of the 20- to 50% decreases occurring in the placebo series. Calculated values of fractional proximal and distal tubular Na reabsorption decreased significantly. ANF caused a decrease in plasma concentrations of active renin and aldosterone, whereas renin substrate, angiotensin I, and angiotensin II concentrations were unaltered. A subtle increase in plasma concentrations of norepinephrine and epinephrine was observed during the ANF infusions. These data suggest that the natriuretic effect of ANF is caused by an increased fluid delivery from the proximal tubule in addition to a fall in fractional distal Na reabsorption.

Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patients

1989 ◽  
Vol 7 ◽  
pp. S300-301 ◽  
Author(s):  
Paolo Dessi-Fulgheri ◽  
Mario Motolese ◽  
Giorgio Di Noto ◽  
Domenico Delfino ◽  
Gilberta Giacchetti ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Volume Expansion ◽  
Hypertensive Patients ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Atrial Natriuretic Factor as a Vasodilator Agent in Hypertensive Patients

1990 ◽  
Vol 300 (2) ◽  
pp. 78-82 ◽  
Author(s):  
Roberto Pedrinelli ◽  
Marzia Spessot ◽  
Giovanni Panarace ◽  
Stefano Taddei ◽  
Stefania Favilla ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Hypertensive Patients ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Does Mild Autonomie Neuropathy Affect Atrial Natriuretic Factor Regulation in Diabetic Hypertensive Patients?

1991 ◽  
Vol 4 (10 Pt 1) ◽  
pp. 832-835 ◽  
Author(s):  
G. D. Mattia ◽  
O. Laurenti ◽  
C. Bravi ◽  
C. Ferri ◽  
C. Bellini ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Hypertensive Patients ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
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