Differential regulation of interleukin-6 production in the kidney by the renal sympathetic nerves in normal and spontaneously hypertensive rats

1993 ◽  
Vol 11 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Akio Nakamura ◽  
Takao Kohsaka ◽  
Edward J. Johns
Keyword(s):  
Interleukin 6 ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerves ◽  
Differential Regulation ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Sympathetic

α2-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats

2002 ◽  
Vol 282 (6) ◽  
pp. H2336-H2345 ◽  
Author(s):  
Linda F. Hayward ◽  
Alecia P. Riley ◽  
Robert B. Felder
Keyword(s):  
Arterial Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Baroreflex Control ◽  
Renal Sympathetic Nerve Activity ◽  
Spontaneously Hypertensive ◽  
Aortic Depressor Nerve ◽  
Baroreflex Function ◽  
Wistar Kyoto ◽  
Renal Sympathetic

We examined the effect of α2-adrenoreceptor blockade in the nucleus of the solitary tract (NTS) on baroreflex responses elicited by electrical stimulation of the left aortic depressor nerve (ADN) in urethane-anesthetized spontaneously hypertensive rats (SHR, n = 11) and normotensive Wistar-Kyoto rats (WKY, n = 11). ADN stimulation produced a frequency-dependent decrease in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and heart rate (HR). In SHR, unilateral microinjection of idazoxan into the NTS markedly reduced baroreflex control of MAP, RSNA, and HR and had a disproportionately greater influence on baroreflex control of MAP than of RSNA. In WKY, idazoxan microinjections did not significantly alter baroreflex function relative to control vehicle injections. These results suggest that baroreflex regulation of arterial pressure in SHR is highly dependent on NTS adrenergic mechanisms. The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered α2-adrenoreceptor mechanisms in SHR.

scholarly journals Renal Sympathetic Nerve Responses to Tempol in Spontaneously Hypertensive Rats

Hypertension ◽  
2003 ◽  
Vol 41 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Takatomi Shokoji ◽  
Akira Nishiyama ◽  
Yoshihide Fujisawa ◽  
Hirofumi Hitomi ◽  
Hideyasu Kiyomoto ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Sympathetic Nerve ◽  
Renal Sympathetic
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