ALDOSTERONE-RECEPTOR ANTAGONISTS LEAD TO PROLONGED BLOOD PRESSURE REDUCTION IN UNCONTROLLED HYPERTENSION: A RETROSPECTIVE ANALYSIS

2011 ◽  
Vol 29 ◽  
pp. e97
Author(s):  
P. M. Jansen ◽  
K. Verdonk ◽  
B. P. Imholz ◽  
A. H.J. Danser ◽  
A. H. van den Meiracker
Keyword(s):  
Blood Pressure ◽  
Retrospective Analysis ◽  
Blood Pressure Reduction ◽  
Uncontrolled Hypertension ◽  
Pressure Reduction ◽  
Receptor Antagonists ◽  
Aldosterone Receptor

scholarly journals Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension: A Retrospective Analysis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Pieter M. Jansen ◽  
Koen Verdonk ◽  
Ben P. Imholz ◽  
A. H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Essential Hypertension ◽  
Primary Aldosteronism ◽  
Treatment Duration ◽  
Uncontrolled Hypertension ◽  
Receptor Antagonists ◽  
Aldosterone Receptor

Background. The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported.Methods. Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available.Results. Systolic BP decreased by22±20and diastolic BP by9.4±12 mmHg after a median treatment duration of 25 months. In patients that received treatment >5 years, SBP was33±20and DBP was 16 ± 13 mmHg lower than at baseline. Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response.Conclusion. Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.

Determinants of blood pressure reduction by eplerenone in uncontrolled hypertension

2013 ◽  
Vol 31 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Pieter M. Jansen ◽  
Wijnanda J. Frenkel ◽  
Bert-Jan H. van den Born ◽  
Emile L.E. de Bruijne ◽  
Jaap Deinum ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Reduction ◽  
Uncontrolled Hypertension ◽  
Pressure Reduction
Sign in / Sign up

Export Citation Format

Share Document