CHRONIC PROGRESSIVE PARANEOPLASTIC SYNDROME WITH PROMINENT BRAINSTEM AND SPINAL CORD INVOLVEMENT, ASSOCIATED WITH TYPE-2 ANTI-NEURONAL NUCLEAR ANTIBODIES (ANNA-2) AND BREAST CARCINOMA

Abstract This 3-dimensional operative video illustrates resection of 2 cervical spine schwannomas in a 19-yr-old female with neurofibromatosis type 2. The patient presented with lower extremity hyperreflexity and hypertonicity. Magnetic resonance imaging (MRI) demonstrated 2 contrast-enhancing intradural extramedullary cervical spine lesions causing spinal cord compression at C4 and C5. The patient underwent a posterior cervical laminoplasty with a midline dural opening for tumor resection. Curvilinear spine cord compression is demonstrated in the operative video. After meticulous dissection, the tumors were resected without complication. The dural closure was performed in watertight fashion followed by laminoplasty using osteoplastic titanium miniplates and screws. Postoperative MRI demonstrated gross total resection with excellent decompression of the spinal cord. The postoperative course was uneventful. The natural history of this disease, treatment options, and potential complications are discussed.

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Spinal cord involvement in posterior reversible encephalopathy syndrome

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.2008.154781 ◽

2008 ◽

Vol 80 (1) ◽

pp. 35-35 ◽

Cited By ~ 9

Author(s):

B Lapuyade ◽

I Sibon ◽

S Jeanin ◽

V Dousset

Keyword(s):

Spinal Cord ◽

Posterior Reversible Encephalopathy Syndrome ◽

Posterior Reversible Encephalopathy ◽

Spinal Cord Involvement ◽

Reversible Encephalopathy

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Crystalline deposits in the macula – tamoxifen maculopathy or macular telangiectasia?

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v6i2.11713 ◽

2014 ◽

Vol 6 (2) ◽

pp. 227-229 ◽

Cited By ~ 4

Author(s):

Roshija Khanal Rijal ◽

Dr Chinmay Nakhwa ◽

Manavi D Sindal D Manavi D Sindal

Keyword(s):

Breast Carcinoma ◽

Past History ◽

Rare Complication ◽

Fundus Autofluorescence ◽

Retinal Layer ◽

Fundus Fluorescein Angiography ◽

Normal Limits ◽

Macular Telangiectasia ◽

Crystalline Deposits

Introduction: Tamoxifen citrate is an anti-estrogen agent used in the treatment of breast carcinoma. Crystalline maculopathy is a rare complication of tamoxifen therapy. The clinical picture resembles that of idiopathic macular telangiectasia (IMT) Type 2, which is a more common clinical entity. Objective: To report a case of crystalline maculopathy secondary to tamoxifen and highlight the importance of the medical history and investigations in differentiating it from IMT Type 2. Case: A diabetic female with a past history of breast carcinoma treated with tamoxifen came to the hospital for a routine eye check-up. Crystalline deposits were seen in the parafoveal region in both the eyes. The spectral domain optical coherence tomography (SD-OCT) showed foveal cysts in the inner retinal layer and fundus autofluorescence (FAF) and fundus fluorescein angiography (FFA) were within normal limits. Conclusion: While tamoxifen maculopathy is reversible on stopping the therapy, IMT needs a long-term follow-up to monitor the potential risk of loss of vision due to choroidal neovascularization, hence necessitating the distinction between these two different clinical entities.DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11713Nepal J Ophthalmol 2014; 6 (12): 227-229

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