The Use of Composite Bone Graft Materials in a Segmental Femoral Defect Model in the Rat

The material properties of nanocellulose (NC) can effectively enhance the structural stability of composite materials. However, the research related to NC/α-calcium sulfate hemihydrate (CSH) composites is largely lacking. In this paper, we explore the combination of these two materials and determine their elaborate biological activities in vivo. Using α-CSH as the matrix, the composite bone graft materials were produced according to different proportions of NC. Then the mechanical strength of the composite bone graft was measured, and the results were analyzed by X-ray diffraction and scanning electron microscopy (SEM). To conduct the material in vivo evaluation, 0% (CN0) and 0.75% (CN0.75) NC/α-CSH composite bone graft materials were implanted into a femoral condyle defect model. The results indicated that NC could significantly enhance the mechanical properties of α-CSH. The SEM analysis indicated that the NC shuttled between the crystal gaps and formed a three-dimensional network structure, which was firmly combined with the crystal structure. Meanwhile, the CN0.75 scaffold remained at 12 weeks postoperation, which provided a long-term framework for new bone formation. Overall, our findings demonstrate that, with a 0.75% NC/α-CSH composite demonstrating good potential as a bone graft material for clinical bone grafting.

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Evaluation of a silica-containing bone graft substitute in a vertebral defect model

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.32397 ◽

2009 ◽

Vol 9999A ◽

pp. NA-NA

Author(s):

Hideo Kobayashi ◽

A. Simon Turner ◽

Howard B. Seim ◽

Teruya Kawamoto ◽

Thomas W. Bauer

Keyword(s):

Bone Graft ◽

Bone Graft Substitute ◽

Defect Model

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Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Materials Today Communications ◽

10.1016/j.mtcomm.2021.102933 ◽

2021 ◽

pp. 102933

Author(s):

William A. Lackington ◽

Dominic Gehweiler ◽

Ivan Zderic ◽

Dirk Nehrbass ◽

Stephan Zeiter ◽

...

Keyword(s):

Therapeutic Efficacy ◽

Weight Bearing ◽

Collagen Scaffolds ◽

Defect Model ◽

Femoral Defect

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Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Materials ◽

10.3390/ma13194391 ◽

2020 ◽

Vol 13 (19) ◽

pp. 4391

Author(s):

Yoona Jung ◽

Won-Hyeon Kim ◽

Sung-Ho Lee ◽

Kyung Won Ju ◽

Eun-Hee Jang ◽

...

Keyword(s):

Bone Formation ◽

Bone Graft ◽

Octacalcium Phosphate ◽

Autogenous Bone ◽

Graft Material ◽

Calvarial Defect ◽

Bone Area ◽

Defect Model ◽

Bone Graft Material ◽

Experimental Group

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

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