Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

2021 ◽  
pp. 102933
Author(s):  
William A. Lackington ◽  
Dominic Gehweiler ◽  
Ivan Zderic ◽  
Dirk Nehrbass ◽  
Stephan Zeiter ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Weight Bearing ◽  
Collagen Scaffolds ◽  
Defect Model ◽  
Femoral Defect

CD34+cells seeded in collagen scaffolds promote bone formation in a mouse calvarial defect model

2017 ◽  
Vol 106 (4) ◽  
pp. 1505-1516 ◽  
Author(s):  
Jens Hertweck ◽  
Ulrike Ritz ◽  
Hermann Götz ◽  
Patrick C Schottel ◽  
Pol Maria Rommens ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Defect ◽  
Collagen Scaffolds ◽  
Defect Model ◽  
Cd34 Cells

scholarly journals A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

10.3791/59206 ◽  
2019 ◽  
Author(s):  
Benjamin Kerzner ◽  
Hannah L. Martin ◽  
Michael Weiser ◽  
Gianluca Fontana ◽  
Nicholas Russell ◽  
...  
Keyword(s):  
External Fixator ◽  
Defect Model ◽  
Femoral Defect

scholarly journals Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model

2013 ◽  
Vol 32 (2) ◽  
pp. 197-203 ◽  
Author(s):  
Farhang Alaee ◽  
Mandeep S. Virk ◽  
Hezhen Tang ◽  
Osamu Sugiyama ◽  
Douglas J. Adams ◽  
...  
Keyword(s):  
Bone Repair ◽  
Systemic Treatment ◽  
Neutralizing Antibody ◽  
Defect Model ◽  
Femoral Defect

Human acellular amniotic membrane: A potential osteoinductive biomaterial for bone regeneration

2017 ◽  
Vol 32 (6) ◽  
pp. 754-764 ◽  
Author(s):  
Kai Tang ◽  
Jiayi Wu ◽  
Zekang Xiong ◽  
Yanhui Ji ◽  
Tingfang Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tissue Engineering ◽  
Bone Marrow ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Amniotic Membrane ◽  
Matrix Material ◽  
Defect Model ◽  
Femoral Defect ◽  
Marrow Mesenchymal Stem Cells

Human acellular amniotic membrane is an acellular, naturally extracellular matrix material with various bioactive factors, which applied in tissue engineering in clinic. Several studies have applied human acellular amniotic membrane in skin and ocular surface tissue engineering to enhance tissue regeneration. However, the application of human acellular amniotic membrane in bone tissue engineering was rarely investigated. The aim of the current study was to investigate the osteoinductivity, angiogenesis and the early molecular changes of human acellular amniotic membrane to bone regeneration. Our results showed that human acellular amniotic membrane with excellent biocompatibility was beneficial for bone marrow mesenchymal stem cells proliferation and osteogenic differentiation. In rat femoral defect model, the existence of human acellular amniotic membrane significantly improved bone regeneration in the defects. The gene expression of CXCR-4, MCP-1, OC and CatK which were connected with cells recruitment and bone remodeling, was enhanced in the defects implanted with human acellular amniotic membrane. The results of this study suggest that human acellular amniotic membrane is an osteoinductive biomaterial for bone regeneration.

scholarly journals Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model

2019 ◽  
Vol 7 ◽  
Author(s):  
Omair A. Mohiuddin ◽  
Brett Campbell ◽  
J. Nick Poche ◽  
Michelle Ma ◽  
Emma Rogers ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Bone Regeneration ◽  
Defect Model ◽  
Femoral Defect
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