Antihypertensive and Metabolic Effects of Long-Term Therapy with Nifedipine Slow-Release Tablets

1985 ◽  
Vol 7 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Knud Landmark
1987 ◽  
Vol 33 (5) ◽  
pp. 515-517 ◽  
Author(s):  
F. Galletti ◽  
P. Strazzullo ◽  
R. Gagliardi ◽  
M. Cirillo ◽  
A. Siani ◽  
...  

1979 ◽  
Vol 57 (s5) ◽  
pp. 367s-369s ◽  
Author(s):  
A. Lechi ◽  
G. Covi ◽  
G. Danti ◽  
A. Dalla Riva ◽  
E. Pedrolli ◽  
...  

1. Tienilic acid and hydrochlorothiazide were evaluated in a double-blind trial in order to investigate their antihypertensive and metabolic effects. 2. After 5 weeks, the decreases in blood pressure and the changes in plasma or serum electrolytes, urea, creatinine, glucose, cholesterol and triglycerides, and in creatinine clearance, did not differ in the two groups of patients. 3. In patients taking tienilic acid a significant decrease in serum uric acid and an increase in urate clearance was observed, whereas in patients receiving hydrochlorothiazide a slight increase in serum uric acid, with no modification of urate clearance, occurred. 4. The diuretic and antihypertensive actions of tienilic acid and hydrochlorothiazide are very similar. The uricosuric/hypouricaemic effect of tienilic acid could assume clinical relevance in long-term therapy of hypertensive patients.


1997 ◽  
Vol 17 (03) ◽  
pp. 161-162
Author(s):  
Thomas Hyers

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.


2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Kungel ◽  
A Engelhardt ◽  
T Spevakné-Göröcs ◽  
M Ebrecht ◽  
C Werner ◽  
...  

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