Bradykinin-Degrading Enzymes: Structure, Function, Distribution, and Potential Roles in Cardiovascular Pharmacology

1992 ◽  
Vol 20 (Supplement 9) ◽  
pp. S4-S9 ◽  
Author(s):  
Randal A. Skidgel
2018 ◽  
Vol 15 (1) ◽  
pp. 87-100 ◽  
Author(s):  
Puja Chandrayan

Pectin is an integral part of plant cell wall and since centuries pectin extracted from plants is widely used in food and fruit juice processing. Moreover, in last half century, the applications have also invaded into many bio-processing applications such as pharmaceutical, bioenergy, textile, paper and tea processing. In these growing industries, the use of pectinases has grown with a significant amount i.e. approximately 10 % of total global enzyme market comes from pectinases. Herein comprehensive analyses of information related to structure and function of pectin in plant cell wall as well as structural classes of pectins have been discussed. The major function of pectin is in cementing the cellulose and hemicelluloses network, cell-cell adhesion and plant defence. Keeping the wide use of pectin in food industry and growing need of environment friendly technology for pectin extraction has accelerated the demand of pectin degrading enzymes (PDEs). PDEs are from three enzyme classes: carbohydrate esterases from CE8 and CE12 family, glycoside hydrolases from GH28 family and lyases from PL1, 2, 3, 9 and 10. We have reviewed the literature related to abundance and structure-function of these abovementioned enzymes from bacteria. From the current available literature, we found very limited information is present about thermostable PDEs. Hence, in future it could be a topic of study to gain the insight about structure-function of enzymes together with the expanded role of thermostable enzymes in development of bioprocesses based on these enzymes.


1992 ◽  
Vol 33 (9) ◽  
pp. 1255-1267
Author(s):  
Y Kishimoto ◽  
M Hiraiwa ◽  
JS O'Brien

1999 ◽  
Vol 46 (1) ◽  
pp. 49-63 ◽  
Author(s):  
Birte Svensson ◽  
Kristian Sass Bak-Jensen ◽  
Morten Tovborg Jensen ◽  
Jørgen Sauer ◽  
Tine E. Gottschalk ◽  
...  

ChemBioChem ◽  
2021 ◽  
Author(s):  
Maria Cristina Menziani ◽  
Alessandro Berselli ◽  
Maria J. Ramos

2014 ◽  
Vol 21 (12) ◽  
pp. 1209-1229
Author(s):  
Mateja Mancek-Keber

Proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes. Their dysregulation and increased expression during inflammation can have devastating consequences, promoting etiology of vascular diseases, inflammatory arthritis, cancer, and allograft rejection. In this review several proteases (ADAMTS, granzymes, plasmin, and kallikreins) with different mechanisms and substrates are described in addition to their physiological roles and contribution to inflammation and inflammatory diseases. Inhibition of proteases may therefore represent an attractive strategy for treatment and herein we describe physiological and engineered inhibitors.


1998 ◽  
Vol 26 (2) ◽  
pp. 198-204 ◽  
Author(s):  
T. E. Gottschalk ◽  
H.-P. Fierobe ◽  
E. Mirgorodskaya ◽  
A. J. Clarke ◽  
D. Tull ◽  
...  

2021 ◽  
Vol 142 ◽  
pp. 112002
Author(s):  
Saeeda Al Jaberi ◽  
Athena Cohen ◽  
Crystal D’Souza ◽  
Yousef M. Abdulrazzaq ◽  
Shreesh Ojha ◽  
...  

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