Serum Prostate Specific Antigen Levels after Transurethral Resection of Prostate

Background: Diseases primarily inflicting prostate gland are inflammation, benign prostatic hyperplasia and cancer. Prostate specific antigen is a protein produced by the cells of prostate gland. It has been widely used in the diagnosis and management of patients with prostatic cancer. The aim this study was to determine the correlation between serum prostate specific antigen level and histological findings in biopsy specimens of men with prostatic disease.Materials and methods: This study was carried out at Kathmandu Medical College and Teaching Hospital, department of Pathology over a period of 2 years. One hundred and twenty eight cases with prostatic lesions were included in this study. Prostate specific antigen values of these cases were recorded before the surgical process. Histology of the tissue samples collected after transurethral resection of prostate was studied and relationship with prostate specific antigen level were analyzed.Results: Benign prostatic hyperplasia was the most common histological lesion encountered (n=95; 74.22%). Prostatic adenocarcinomas were seen a decade older than those with benign lesions. Maximum number of the benign cases had the Prostate specific antigen range of 0-7ng/ml. Most of the prostatic intraepithelial neoplasia lesions were seen within the PSA range of 0-7ng/ml and adenocarcinoma in the range of >20ng/ml.Conclusion: Prostate specific antigen is specific for the prostate but not for prostate cancer. Both benign and malignant lesions in prostate can cause increase in serum prostate specific antigen levels, but the chances of malignancy it rising level.

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LONGITUDINAL FOLLOW-UP OF SERUM PROSTATE SPECIFIC ANTIGEN (PSA) LEVELS FOLLOWING TRANSURETHRAL RESECTION OF THE PROSTATE (TURP) FOR BENIGN PROSTATIC HYPERPLASIA (BPH)

The Journal of Urology ◽

10.1097/00005392-199904020-00212 ◽

1999 ◽

pp. 302

Author(s):

Scott M. Sech ◽

Clark Tingleaf ◽

Allison Ahrens ◽

Claus G. Roehrborn

Keyword(s):

Benign Prostatic Hyperplasia ◽

Prostate Specific Antigen ◽

Transurethral Resection ◽

Specific Antigen ◽

Prostatic Hyperplasia ◽

Serum Prostate Specific Antigen

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Change in Free To Total Prostate Specific Antigen Ratio Following Transurethral Resection of Prostate in Patient With Benign Prostatic Hyperplasia

Bangladesh Journal of Urology ◽

10.3329/bju.v18i2.49283 ◽

2020 ◽

Vol 18 (2) ◽

pp. 83-87

Author(s):

SM Yunus Ali ◽

Md Saiful Islam ◽

Mohammad Al Amin ◽

Md Golam Mowla Choudhury ◽

Isteaq Ahmed Shamim

Keyword(s):

Prostate Specific Antigen ◽

Transurethral Resection ◽

Histopathological Examination ◽

Urinary Tract Obstruction ◽

Specific Antigen ◽

Total Serum ◽

Transurethral Resection Of Prostate ◽

Free Psa ◽

Lower Urinary Tract Obstruction ◽

Total Psa

Objective- To determine the changes in free to total serum prostate specific antigen (PSA) ratio level after transurethral resection of prostate (TURP) in BPH patients at different interval of time. Materials & Methods- A total of 93 patients undergoing TURP for benign enlargement of prostate were included in the study. Serum total PSA and free PSA were assessed before operation and on the Ist and 7th postoperative day and at month 3 to determine the changes in total PSA, free PSA and free to total PSA ratio following TURP. Result- The preoperative mean total PSA, free PSA and free to total PSA ratio were 3.5 :L 1.7 ng/ml, 0.781 0.21 ng/ml and 0.28 + 0.07. In terms of IPSS, 75(80.7%) patients had severe lower urinary tract obstruction and 18(19.3%) moderate obstruction. Histopathological examination of the resected prostatic tissue revealed that all the 93 patients had benign prostatic lesion. Conclusion-The free and total PSA in first few days increases and thereafter it decreases in 3 months period following transurethral resection of prostate in men with BPH. As both these parameters decrease proportionately, the free to total PSA ratio remains consistent. If free to total PSA ratio decreases it raises suspicision about the early changes in malignancy. Bangladesh Journal of Urology, Vol. 18, No. 2, July 2015 p.83-87

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