The Prognostic Significance of Lymph-Vascular Space Invasion in Stage I Endometrial Cancer

Background/Aim. Endometrial carcinoma is the most common malignant neoplasm of the female genital tract in developed countries. Endometrioid carcinoma represents about three-fourths of all endometrial carcinoma. The aim of this study was to examine pathologic parameters, age, and the 5-year survival of the patients with FIGO stage I endometrial carcinoma of endometrioid type and to assess the prognostic utility of age, depth of myometrial invasion, hystologic type (endometrioid or variant), histologic grade, nuclear grade, and lymph-vascular space invasion. Methods. Age, pathologic parameters, and survival data were retrospectively collected on 236 patients with FIGO stage I endometrial carcinoma of endometrioid type. All the patients underwent hysterectomy between 1996 and 2000 and follow-up until December 2005. Results. A total of 236 patients (mean age 58.0, range 40?79) were analyzed. During the 5-year period of follow-up, 59 (25.0%) patents died from the disease. An univariate analysis revealed that age, depth of myometrial invasion, histologic grade, nuclear grade, and lymph-vascular space invasion were associated significantly with the 5-year survival of the patients. A multivariate analysis revealed that age, lymph-vascular space invasion, and depth of myometrial invasion were associated significantly with the 5-year survival. Conclusion. Age, lymph-vascular space invasion, and depth of myometrial invasion are independent prognostic parameters for the 5-year survival of the patients with FIGO stage I endometrial carcinoma of endometrioid type.

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Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer

Journal of Gynecologic Oncology ◽

10.3802/jgo.2021.32.e11 ◽

2021 ◽

Vol 32 (2) ◽

Cited By ~ 1

Author(s):

Lucia Tortorella ◽

Stefano Restaino ◽

Gian Franco Zannoni ◽

Giuseppe Vizzielli ◽

Vito Chiantera ◽

...

Keyword(s):

Endometrial Cancer ◽

Poor Prognosis ◽

Early Stage ◽

Low Risk ◽

Distant Relapse ◽

Vascular Space ◽

Early Stage Endometrial Cancer ◽

Vascular Space Invasion

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EP626 Lymph vascular space invasion, an independent risk factor of sentinel node mapping failure in endometrial cancer, the sentifail study: a multicentric prospective analysis

10.1136/ijgc-2019-esgo.683 ◽

2019 ◽

Author(s):

G Sozzi ◽

FM Re ◽

R Berretta ◽

G Lo Balbo ◽

V Giallombardo ◽

...

Keyword(s):

Endometrial Cancer ◽

Risk Factor ◽

Sentinel Node ◽

Independent Risk Factor ◽

Prospective Analysis ◽

Sentinel Node Mapping ◽

Vascular Space ◽

Vascular Space Invasion

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Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200201000-00008 ◽

2002 ◽

Vol 12 (1) ◽

pp. 49-56 ◽

Cited By ~ 1

Author(s):

A Ørbo ◽

M Rydningen ◽

B Straume ◽

S Lysne

Keyword(s):

Endometrial Cancer ◽

Cancer Patients ◽

Vascular Invasion ◽

Prognostic Markers ◽

Dna Ploidy ◽

Prognostic Significance ◽

Figo Stage ◽

Stage I ◽

Northern Norway

Abstract.Ørbo A, Rydningen M, Straume B, Lysne S. Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway.The objective of this study was to evaluate the prognostic value of nuclear morphometric features and DNA ploidy by flow cytometry next to depth of myometrial invasion and vascular invasion in endometrial cancer of all FIGO stages.A total of 123 women (103 FIGO stage I, eight stage II, and 12 stage III and IV) from northern Norway were studied. The follow-up period was between 7 and 19 years. The median age of patients was 62 years. The primary surgery was performed in the University Hospital of Tromsø or in the seven different reference hospitals in the northern part of Norway after an endometrial cancer diagnosis. The histologic, morphometric, flowcytometric and immunohistochemical investigations were based on archival paraffin-embedded material. The information regarding the follow-up data and clinical information were obtained from the medical records.Thirteen (10.6%) patients from the entire group (all stages) but only three (2.7%) of the FIGO stage I and II patients died from locally recurrent or metastatic disease. FIGO substage (P = 0.0006; odds ratio [OR] = 16.44, 95% confidence interval [CI] = 3.36–80.45), vascular invasion (P = 0.01, OR = 6.42, CI = 1.57–26.34) and nuclear size (P = 0.025, 0 R = 1.3, CI = 1.05–1.61) were independently correlated with recurrence in a multivariate analysis but histologic grade and DNA ploidy were not. Vascular invasion was poorly reproducible both between and within the same observer, however.In this retrospective study of all stages of endometrial carcinoma with long follow-up periods the primary tumor characteristics nuclear perimeter and FIGO stage were of prognostic significance in addition to the poorly reproducible vessel invasion.

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