FIBRONECTIN LEVELS IN PREMATURE INFANTS WITH A LATE-ONSET SEPSIS

1994 ◽  
Vol 13 (1) ◽  
pp. 84
Author(s):  
M. S. Edwards
Keyword(s):  
Premature Infants ◽  
Late Onset ◽  
Late Onset Sepsis

Tocopherol Efficacy and Safety for Preventing Retinopathy of Prematurity: A Randomized, Controlled, Double-Masked Trial

PEDIATRICS ◽  
1987 ◽  
Vol 79 (4) ◽  
pp. 489-500 ◽  
Author(s):  
Dale L. Phelps ◽  
Arthur L. Rosenbaum ◽  
Sherwin J. lsenberg ◽  
Rosemary D. Leake ◽  
Frederick J. Dorey
Keyword(s):  
Premature Infants ◽  
Retinopathy Of Prematurity ◽  
Plasma Levels ◽  
Late Onset ◽  
Retinal Hemorrhage ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Late Onset Sepsis ◽  
Prospective Monitoring

To test the efficacy and safety of vitamin E in preventing retinopathy of prematurity, 287 infants with birth weights of less than 1.5 kg or gestational ages of less than 33 weeks were enrolled within 24 hours of birth in a randomized, double-masked trial of IV, followed by oral, placebo v tocopherol (adjusted to plasma levels of 3 to 3.5 mg/dL). In the 196 infants completing ophthalmic follow-up, tocopherol did not prevent retinopathy of prematurity of any stage (28% placebo treated v 26% tocopherol treated) or moderately severe retinopathy of prematurity (8% placebo treated v 11% tocopherol treated). Cicatricial sequelae were not significantly different (1/97 placebo treated v 3/99 tocopherol treated), with one placebo-treated infant and one tocopherol-treated infant having retinal detachments. Among all 232 infants examined, those treated with tocopherol had more retinal hemorrhage than placebo-treated infants (8/121 placebo treated v 16/111 tocopherol treated), and retinal hemorrhage correlated positively (P < .01) with plasma levels of tocopherol after the first 2 weeks of age. Prospective monitoring of morbidity including late-onset sepsis, necrotizing enterocolitis, etc revealed no differences between groups except that grades 3 and 4 intraventricular hemorrhage occurred more frequently in infants weighing less than 1 kg at birth who had received tocopherol (14/42, 33%) v those who had received placebo (4/43, 9%) (P < .02). Our data do not support the use of tocopherol for prophylaxis against retinopathy of prematurity in premature infants and suggest that IV tocopherol treatment starting on day 1 may increase the incidence of hemorrhagic complications of prematurity, particularly in infants with birth weights of less than 1 kg.

Optimized Detection of Central Apneas Preceding Late-Onset Sepsis in Premature Infants

2021 ◽  
Author(s):  
Gabriele Varisco ◽  
Deedee Kommers ◽  
Xi Long ◽  
Zhuozhao Zhan ◽  
Marina M. Nano ◽  
...  
Keyword(s):  
Premature Infants ◽  
Late Onset ◽  
Late Onset Sepsis ◽  
Central Apneas

scholarly journals Intestinal microbiome colonization patterns differ prior to late onset sepsis in premature infants (637.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Diana Taft ◽  
Doyle Ward ◽  
Kurt Schibler ◽  
Zhuoteng Yu ◽  
David Newburg ◽  
...  
Keyword(s):  
Premature Infants ◽  
Late Onset ◽  
Intestinal Microbiome ◽  
Late Onset Sepsis ◽  
Colonization Patterns

scholarly journals Trajectories of the heart rate characteristics index, a physiomarker of sepsis in premature infants, predict Neonatal ICU mortality

2020 ◽  
Vol 9 ◽  
pp. 204800402094514
Author(s):  
Amanda M Zimmet ◽  
Brynne A Sullivan ◽  
J Randall Moorman ◽  
Douglas E Lake ◽  
Sarah J Ratcliffe
Keyword(s):  
Heart Rate ◽  
Premature Infants ◽  
Neonatal Intensive Care ◽  
Time Course ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Low Birth Weight Infants ◽  
Late Onset Sepsis ◽  
Neonatal Icu ◽  
Time Courses

Objective Trajectories of physiomarkers over time can be useful to define phenotypes of disease progression and as predictors of clinical outcomes. The aim of this study was to identify phenotypes of the time course of late-onset sepsis in premature infants in Neonatal Intensive Care Units. Methods We examined the trajectories of a validated continuous physiomarker, abnormal heart rate characteristics, using functional data analysis and clustering techniques. Participants We analyzed continuous heart rate characteristics data from 2989 very low birth weight infants (<1500 grams) from nine NICUs from 2004–2010. Result Despite the relative homogeneity of the patients, we found extreme variability in the physiomarker trajectories. We identified phenotypes that were indicative of seven and 30 day mortality beyond that predicted by individual heart rate characteristics values or baseline demographic information. Conclusion Time courses of a heart rate characteristics physiomarker reveal snapshots of illness patterns, some of which were more deadly than others.

scholarly journals Late-onset Sepsis in Extremely Premature Infants

2017 ◽  
Vol 36 (8) ◽  
pp. 774-779 ◽  
Author(s):  
Rachel G. Greenberg ◽  
Sarah Kandefer ◽  
Barbara T. Do ◽  
P. Brian Smith ◽  
Barbara J. Stoll ◽  
...  
Keyword(s):  
Premature Infants ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Is Urine Interleukin-8 Level a Reliable Laboratory Test for Diagnosing Late Onset Sepsis in Premature Infants?

2007 ◽  
Vol 53 (6) ◽  
pp. 403-408 ◽  
Author(s):  
M. R. Bentlin ◽  
L. M. S. de Souza Rugolo ◽  
A. R. Junior ◽  
M. Hashimoto ◽  
J. C. Lyra
Keyword(s):  
Laboratory Test ◽  
Premature Infants ◽  
Late Onset ◽  
Interleukin 8 ◽  
Late Onset Sepsis

scholarly journals Risk factors and prevention of late-onset sepsis in premature infants

2010 ◽  
Vol 86 (1) ◽  
pp. 7-12 ◽  
Author(s):  
L. Corbin Downey ◽  
P. Brian Smith ◽  
Daniel K. Benjamin
Keyword(s):  
Risk Factors ◽  
Premature Infants ◽  
Late Onset ◽  
Late Onset Sepsis
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