ATYPICAL PSEUDOEPITHELIOMATOUS HYPERPLASIA IN SQUAMOUS CELL CARCINOMA IN CHRONIC WOUNDS

Squamous cell carcinomas are often seen on the sun-exposed areas of the skin and are rarely observed on the digits of the foot. However, there have been incidences of squamous cell carcinoma developing in the presence of chronic wounds with osteomyelitis, thus complicating the treatment. We present a patient with osteomyelitis who developed invasive squamous cell carcinoma of the third digit. We conclude that wounds with osteomyelitis may have underlying pathologic abnormalities that are not obvious on initial presentation.

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Cutaneous Leishmaniasis With Pseudoepitheliomatous Hyperplasia Simulating Squamous Cell Carcinoma

American Journal of Dermatopathology ◽

10.1097/dad.0b013e31820977d1 ◽

2011 ◽

Vol 33 (6) ◽

pp. 642-644 ◽

Cited By ~ 4

Author(s):

Leonardo Pereira Quintella ◽

Tullia Cuzzi ◽

Maria de Fátima Madeira ◽

Cláudia Maria Valete-Rosalino ◽

Mariza de Matos Salgueiro ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Cutaneous Leishmaniasis ◽

Squamous Cell ◽

Pseudoepitheliomatous Hyperplasia

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Hypertrophic Lichen Planus versus Well-Differentiated Squamous Cell Carcinoma: A Histological Challenge

SKIN The Journal of Cutaneous Medicine ◽

10.25251/10.25251/skin.1.2.6 ◽

2017 ◽

Vol 1 (2) ◽

pp. 91

Author(s):

Samuel P Haslam ◽

Lindy S Ross ◽

Alison C Lowe ◽

Brent C Kelly

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Multiplex Pcr ◽

Lichen Planus ◽

Squamous Cell ◽

Correct Diagnosis ◽

Pseudoepitheliomatous Hyperplasia ◽

Lichen Simplex Chronicus ◽

Well Differentiated

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP.

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Case of development of Gottron’s carcinoid papillomatosis of skin against a background of protracted psoriasis

Perm Medical Journal ◽

10.17816/pmj36676-82 ◽

2020 ◽

Vol 36 (6) ◽

pp. 76-82

Author(s):

M. Yu. Kobernik ◽

V. D. Elkin ◽

T. G. Sedova ◽

A. A. Zhukova

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinical Picture ◽

Skin Disease ◽

Clinical Observation ◽

Lower Extremities ◽

Pseudoepitheliomatous Hyperplasia ◽

First Time

The paper presents information regarding a rare skin disease Gottrons carcinoid papillomatosis, for the first time described in 1932 by German dermatologist H.A. Gottron. Its development is associated with the preceding chronic dermatoses and disturbance of circulation in the lower extremities. Morphologically, Gottrons carcinoid papillomatosis of the skin is characterized by the development of pseudoepitheliomatous hyperplasia of epidermis. Clinical picture, dermatoscopy, ultrasound and histological studied were used for diagnosis. This disease should be differed from high differentiated squamous cell carcinoma of the skin, chronic ulcerous pyodermavegetans, lupus verrucosis, chromomycosis. We described our own clinical observation of Gottrons carcinoid papillomatosis of the skin, developed against a background of psoriasis.

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