RENOPROTECTIVE EFFECTS OF THE 21-AMINOSTEROID U74389G IN ISCHEMIA-REPERFUSION INJURY AND COLD STORAGE PRESERVATION1,2

1997 ◽  
Vol 63 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Paul J. Garvin ◽  
Michael L. Niehoff ◽  
Sandra M. Robinson ◽  
Bhargav Mistry ◽  
Robert Esterl ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion

Prolonged Mouse Cardiac Graft Cold Storage via Attenuating Ischemia-Reperfusion Injury Using a New Antioxidant-Based Preservation Solution

2016 ◽  
Vol 100 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Songjie Cai ◽  
Naotsugu Ichimaru ◽  
Mingyi Zhao ◽  
Masayuki Fujino ◽  
Hidenori Ito ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Preservation Solution ◽  
Cardiac Graft

Influence of Cold Storage on Renal Ischemia Reperfusion Injury after Non-Heart-Beating Donor Explantation

2004 ◽  
Vol 96 (3) ◽  
pp. e97-e102 ◽  
Author(s):  
Sven Dittrich ◽  
David A. Groneberg ◽  
Johanna von Loeper ◽  
Frank Lippek ◽  
Olaf Hegemann ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heart Beating ◽  
Renal Ischemia Reperfusion Injury

Poly(ADP-ribose) polymerase and renal hypothermic preservation injury

2004 ◽  
Vol 286 (5) ◽  
pp. F838-F847 ◽  
Author(s):  
Martin J. Mangino ◽  
Mary Ametani ◽  
Csaba Szabó ◽  
James H. Southard
Keyword(s):  
Enzyme Activity ◽  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Synthesis Rate ◽  
Renal Tubules ◽  
Hypothermic Preservation ◽  
Preservation Injury ◽  
Parp Activity

The nuclear enzyme poly(ADP-ribose) polymerase (PARP) has been implicated in ischemia-reperfusion injury in many tissues under normothermic conditions. The purpose of this study was to determine whether PARP contributes to mechanisms of the hypothermic ischemia-reperfusion injury that occurs when kidneys are cold stored for transplantation. Cortical tissue slice PARP enzyme activity rose significantly with prolonged cold storage and was dependent on both reperfusion and preservation quality. However, prior exposure to warm ischemia abrogated this increase. PARP protein increased with cold storage but was not dependent on reperfusion. PARP enzyme activity rose quickly after reperfusion in buffer and was not different when whole blood was used. Addition of exogenous hydrogen peroxide (3 mM) to normal renal slices significantly increased PARP activity over 4 h in the cortex but not in the medulla, but the medullary basal PARP synthesis rate was five times higher than that in the cortex. However, the reactive oxygen species (ROS) inhibitors catalase (2,000 U/ml), Trolox (200 μM), and DMSO (15 mM) did not reduce reperfusion-induced PARP activity in cold-stored cortical slices. Finally, PARP inhibitors potentiated preservation injury in isolated canine proximal renal tubules. In conclusion, canine renal PARP enzyme activity rises with prolonged cold storage after reperfusion and may play a protective rather than an injurious role in hypothermic preservation for transplantation. ROS are sufficient but not necessary to activate PARP under these conditions.

scholarly journals Hydrogen Flush After Cold Storage as a New End‐Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury

2018 ◽  
Vol 24 (11) ◽  
pp. 1589-1602 ◽  
Author(s):  
Ichiro Tamaki ◽  
Koichiro Hata ◽  
Yusuke Okamura ◽  
Yermek Nigmet ◽  
Hirofumi Hirao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ex Vivo ◽  
Ischemia Reperfusion
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