Prolonged Mouse Cardiac Graft Cold Storage via Attenuating Ischemia-Reperfusion Injury Using a New Antioxidant-Based Preservation Solution

2016 ◽  
Vol 100 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Songjie Cai ◽  
Naotsugu Ichimaru ◽  
Mingyi Zhao ◽  
Masayuki Fujino ◽  
Hidenori Ito ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Preservation Solution ◽  
Cardiac Graft

scholarly journals Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury

2010 ◽  
Vol 139 (4) ◽  
pp. 1048-1056 ◽  
Author(s):  
Sivakkanan Loganathan ◽  
Tamás Radovits ◽  
Kristóf Hirschberg ◽  
Sevil Korkmaz ◽  
Achim Koch ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Organ Preservation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Preservation Solution ◽  
Organ Preservation Solution

scholarly journals Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3592
Author(s):  
Aneta Ostróżka-Cieślik ◽  
Barbara Dolińska ◽  
Florian Ryszka
Keyword(s):  
Reperfusion Injury ◽  
Activity Concentration ◽  
Ischemia Reperfusion Injury ◽  
Therapeutic Potential ◽  
Ischemia Reperfusion ◽  
Antioxidant Properties ◽  
Preservation Solution ◽  
Kidney Preservation ◽  
Preservation Solutions ◽  
Metabolic Reduction

Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol® (modified Biolasol®), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se4+ ions at a dose of 1 µg/L into the Biolasol® preservation solution in the form of Na2SeO3 caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se4+ on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol® modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO32−) during ischemia/reperfusion.

Influence of Cold Storage on Renal Ischemia Reperfusion Injury after Non-Heart-Beating Donor Explantation

2004 ◽  
Vol 96 (3) ◽  
pp. e97-e102 ◽  
Author(s):  
Sven Dittrich ◽  
David A. Groneberg ◽  
Johanna von Loeper ◽  
Frank Lippek ◽  
Olaf Hegemann ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Heart Beating ◽  
Renal Ischemia Reperfusion Injury

RENOPROTECTIVE EFFECTS OF THE 21-AMINOSTEROID U74389G IN ISCHEMIA-REPERFUSION INJURY AND COLD STORAGE PRESERVATION1,2

1997 ◽  
Vol 63 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Paul J. Garvin ◽  
Michael L. Niehoff ◽  
Sandra M. Robinson ◽  
Bhargav Mistry ◽  
Robert Esterl ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion
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