Thymoglobulin Versus Basiliximab Induction Therapy for Kidney Transplant From Deceased Donor With Acute Kidney Injury.

2014 ◽  
Vol 98 ◽  
pp. 583
Author(s):  
C. Jung ◽  
H. Jun ◽  
M. Kim ◽  
K. Park ◽  
S. Kim
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Kidney Injury ◽  
Deceased Donor

scholarly journals Impact of deceased donor with acute kidney injury on subsequent kidney transplant outcomes–an ANZDATA registry analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0249000
Author(s):  
Juan Pei ◽  
Yeoungjee Cho ◽  
Yong Pey See ◽  
Elaine M. Pascoe ◽  
Andrea K. Viecelli ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Kidney Transplant ◽  
Graft Failure ◽  
Cox Regression ◽  
Graft Function ◽  
Kidney Injury ◽  
Deceased Donor ◽  
Hazard Ratio

Background The need for kidney transplantation drives efforts to expand organ donation. The decision to accept organs from donors with acute kidney injury (AKI) can result in a clinical dilemma in the context of conflicting reports from published literature. Material and methods This observational study included all deceased donor kidney transplants performed in Australia and New Zealand between 1997 and 2017. The association of donor-AKI, defined according to KDIGO criteria, with all-cause graft failure was evaluated by multivariable Cox regression. Secondary outcomes included death-censored graft failure, death, delayed graft function (DGF) and acute rejection. Results The study included 10,101 recipients of kidneys from 5,774 deceased donors, of whom 1182 (12%) recipients received kidneys from 662 (11%) donors with AKI. There were 3,259 (32%) all-cause graft failures, which included 1,509 deaths with functioning graft. After adjustment for donor, recipient and transplant characteristics, donor AKI was not associated with all-cause graft failure (adjusted hazard ratio [HR] 1.11, 95% CI 0.99–1.26), death-censored graft failure (HR 1.09, 95% CI 0.92–1.28), death (HR 1.15, 95% CI 0.98–1.35) or graft failure when death was evaluated as a competing event (sub-distribution hazard ratio [sHR] 1.07, 95% CI 0.91–1.26). Donor AKI was not associated with acute rejection but was associated with DGF (adjusted odds ratio [OR] 2.27, 95% CI 1.92–2.68). Conclusion Donor AKI stage was not associated with any kidney transplant outcome, except DGF. Use of kidneys with AKI for transplantation appears to be justified.

scholarly journals First Reported Case in Romania of a Successfully Treated Severe COVID-19 in a Kidney Transplant Recipient: A Focus on Acute Kidney Injury

2020 ◽  
Vol 10 (3) ◽  
pp. 174-179
Author(s):  
Flaviu Tosa ◽  
Roxana Manaila ◽  
Alina Elec ◽  
Tudor Moisoiu ◽  
Liviu Ghervan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Clinical Status ◽  
Organ Transplant ◽  
Treatment Strategies ◽  
Kidney Injury ◽  
Kidney Graft ◽  
Kidney Involvement

As coronavirus disease 2019 (COVID-19) caused by the novel virus SARS-CoV-2 is expanding worldwide, kidney involvement seems to be part of the spectrum of its effects. Moreover, the prognosis of the disease seems to be worse in immunocompromised patients when compared to the general population, with 4–5 times higher mortality rates. However, the overall impact on long-term function of the kidney graft is unknown. We report on a case of a 46-year-old kidney transplant recipient who was successfully treated for severe COVID-19 pneumonia. The clinical course was complicated by transient acute kidney injury, most likely due to tubulo-interstitial involvement, with return to the baseline of the creatinine level by the time of discharge. We discuss the characteristics and differential diagnosis of acute kidney injury, as well as management of immunosuppression in connection with overall clinical status and evolution of kidney function. The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based, efficient COVID-19 therapy. The risk-benefit balance of the yet to be approved treatment strategies may be weighed differently in organ transplant recipients owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy.

FP784LONG TERM GRAFT FUNCTION IN KIDNEY TRANSPLANT RECIPIENTS OF DECEASED DONORS WITH ACUTE KIDNEY INJURY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Reinis Lulle ◽  
Gritane Klinta ◽  
Asare Lasma ◽  
Jushinskis Janis ◽  
Malcevs Aleksandrs ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Graft Function ◽  
Kidney Injury ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Deceased Donors

scholarly journals Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival

2020 ◽  
Vol 3 (1) ◽  
pp. e1918634 ◽  
Author(s):  
Caroline Liu ◽  
Isaac E. Hall ◽  
Sherry Mansour ◽  
Heather R. Thiessen Philbrook ◽  
Yaqi Jia ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Graft Survival ◽  
Kidney Injury ◽  
Deceased Donor

scholarly journals Validation of Administrative Database Codes for Acute Kidney Injury in Kidney Transplant Recipients

2016 ◽  
Vol 3 ◽  
pp. 108 ◽  
Author(s):  
Amber O. Molnar ◽  
Carl van Walraven ◽  
Eric McArthur ◽  
Dean Fergusson ◽  
Amit X. Garg ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Transplant ◽  
Kidney Injury ◽  
Administrative Database ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts

2020 ◽  
Vol 9 (9) ◽  
pp. 2986 ◽  
Author(s):  
Smaragdi Marinaki ◽  
Stathis Tsiakas ◽  
Maria Korogiannou ◽  
Konstantinos Grigorakos ◽  
Vassilios Papalois ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
Deceased Donor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Male Predominance ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
The Mean

The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to physicians and healthcare systems worldwide. Evidence about kidney transplant (KTx) recipients is still limited. A systematic literature review was performed. We included 63 articles published from 1 January until 7 July 2020, reporting on 420 adult KTx recipients with confirmed COVID-19. The mean age of patients was 55 ± 15 years. There was a male predominance (67%). The majority (74%) were deceased donor recipients, and 23% were recently transplanted (<1 year). Most patients (88%) had at least one comorbidity, 29% had two, and 18% three. Ninety-three percent of cases were hospitalized. Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. From the hospitalized patients a total of 22% died, 59% were discharged, and 19% were still in hospital at the time of publication. Immunosuppression was reduced in 27%, discontinued in 31%, and remained unchanged in 5%. Hydroxychloroquine was administered to 78% of patients, antibiotics to 73%, and antivirals to 30% while 25% received corticosteroid boluses, 28% received anti-interleukin agents, and 8% were given immunoglobulin. The main finding of our analysis was that the incidence of COVID-19 among kidney transplant patients is not particularly high, but when they do get infected, this is related to significant morbidity and mortality.

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