scholarly journals NEONATAL ADMINISTRATION OF THE SELECTIVE SEROTONIN REUPTAKE INHIBITOR LU 10???134-C INCREASES FORCED SWIMMING-INDUCED IMMOBILITY OF ADULT RATS

1996 ◽  
Vol 7 (Supplement 1) ◽  
pp. 49
Author(s):  
F HAOUR ◽  
C MARQUETTE ◽  
M JAFARIAN ◽  
M GABELLEC ◽  
M CRUMEYROLLE
Keyword(s):  
Selective Serotonin Reuptake Inhibitor ◽  
Reuptake Inhibitor ◽  
Serotonin Reuptake ◽  
Forced Swimming ◽  
Selective Serotonin ◽  
Serotonin Reuptake Inhibitor ◽  
Adult Rats ◽  
Neonatal Administration

scholarly journals Action of selective serotonin reuptake inhibitor on aggressive behavior in adult rat submitted to the neonatal malnutrition

2001 ◽  
Vol 59 (3A) ◽  
pp. 499-503 ◽  
Author(s):  
Jairza Maria Barreto Medeiros ◽  
Cristiano Mendes da Silva ◽  
Everton Botelho Sougey ◽  
José Audisio Costa ◽  
Célia Maria M. Barbosa de Castro ◽  
...  
Keyword(s):  
Selective Serotonin Reuptake Inhibitor ◽  
Reuptake Inhibitor ◽  
Serotonin Reuptake ◽  
Critical Period ◽  
Saline Solution ◽  
Control Diet ◽  
Selective Serotonin ◽  
Serotonin Reuptake Inhibitor ◽  
Adult Rats ◽  
Adult Rat

The effect of the malnutrition during suckling on the aggressiveness was investigated in adult rats treated or not with citalopram, a selective serotonin reuptake inhibitor (SSRI). The animals were divided into two groups according to the diet used: nourished group-- the rats received the control diet with 23% protein during the life; and malnourished group-- the rats had its mothers submitted to diet with 7.8% protein during suckling. At 120 days of age, each group was sub-divided according to the treatment: acute -- consisting a single i.p. injection of saline solution or 20-mg/Kg citalopram; chronic -- consisting the single injections (1 per day during 14 days) of saline or 20 mg/Kg citalopram. The acute or chronic treatment with SSRI reduces aggressive response in nourished rats, but not in malnourished ones. Thus, the malnutrition during the critical period of brain development seems to induce durable alterations in the function of the serotoninergic neurotransmission

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