LEVELS OF APC, S-PROTEIN C RECEPTOR AND THROMBOMODULIN IN MENINGOCOCCAL SEPTIC SHOCK ARE RELATED TO SURVIVAL.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 55-56
Author(s):  
J A Hazelzet ◽  
E D de Kleijn ◽  
R de Groot ◽  
D. J. Stearns-Kurosawa ◽  
Shinichiro Kurosawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Protein C ◽  
S Protein ◽  
Meningococcal Septic Shock

Coagulation Activation and Tissue Necrosis in Meningococcal Septic Shock: Severely Reduced Protein C Levels Predict a High Mortality

1995 ◽  
Vol 73 (01) ◽  
pp. 015-020 ◽  
Author(s):  
Karin Fijnvandraat ◽  
Bert Derkx ◽  
Marjolein Peters ◽  
Rob Bijlmer ◽  
Augueste Sturk ◽  
...  
Keyword(s):  
Septic Shock ◽  
Protein C ◽  
Purpura Fulminans ◽  
Clinical Signs ◽  
Protein S ◽  
Coagulation System ◽  
Protein C Deficiency ◽  
Free Protein ◽  
Meningococcal Septic Shock ◽  
Protein C Activity

SummaryIn 35 consecutively admitted children (mean age: 4.3 years) with a clinical diagnosis of meningococcal septic shock (MSS), activation of the coagulation and fibrinolytic pathways was evaluated directly at admittance to the paediatric intensive care unit (ICU). The association of clinical signs and haemostatic abnormalities was assessed.All patients had signs of extensive activation of the coagulation system. The 28-day mortality was 26%. Protein C activity was strongly reduced, especially in non-survivors in whom it was significantly lower than in survivors (5% versus 23%; p <0.0001). There was a strong negative correlation between protein C activity and the mean size of the skin lesions (r = -0.71, p <0.001). These results suggest that an acquired protein C deficiency in MSS is related to the pathogenesis of purpura fulminans.Furthermore, no increase in C4b-binding protein (C4BP) and no decrease in the ratio free protein S/total protein S was observed, suggesting that a deficiency of free protein S as a result of increased C4BP does not play a pathogenetic role in meningococcal septic shock.

scholarly journals Fulminant meningococcal septic shock in a boy with combined inherited properdin and protein C deficiency

2008 ◽  
Vol 102 (2) ◽  
pp. 290-296 ◽  
Author(s):  
C. A. P. FIJEN ◽  
B. H. F. DERKX ◽  
E. J. KUIJPER ◽  
M. MANNENS ◽  
S. R. POORT ◽  
...  
Keyword(s):  
Septic Shock ◽  
Protein C ◽  
Protein C Deficiency ◽  
Meningococcal Septic Shock

Early treatment with activated protein C for meningococcal septic shock: case report and literature review

2005 ◽  
Vol 31 (7) ◽  
pp. 1002-1003 ◽  
Author(s):  
Tal Hasin ◽  
David Leibowitz ◽  
David Rot ◽  
Yoram Weiss ◽  
Tova Chajek-Shaul ◽  
...  
Keyword(s):  
Septic Shock ◽  
Case Report ◽  
Literature Review ◽  
Early Treatment ◽  
Protein C ◽  
Activated Protein C ◽  
Meningococcal Septic Shock
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