Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder

1996 ◽  
Vol 6 (4) ◽  
pp. 177-182 ◽  
Author(s):  
S. Battersby ◽  
A. D. Ogilvie ◽  
C. A.D. Smith ◽  
D. H.R. Blackwood ◽  
W. J. Muir ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Serotonin Transporter ◽  
Tandem Repeat ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

scholarly journals Neuroticism and polymorphisms in the serotonin transporter gene

1999 ◽  
Vol 29 (3) ◽  
pp. 735-739 ◽  
Author(s):  
I. J. DEARY ◽  
S. BATTERSBY ◽  
M. C. WHITEMAN ◽  
J. M. CONNOR ◽  
F. G. R. FOWKES ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Personality Trait ◽  
Gene Polymorphisms ◽  
Haplotype Analysis ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Tandem Repeat Region ◽  
Significant Linkage

Background. There is evidence for an association between two different polymorphisms of the human serotonin transporter gene (5-HTT) and the personality trait of neuroticism and affective disorder.Methods. We studied the association between neuroticism and polymorphisms in the 5HTT-linked promoter region and in a variable number tandem repeat region (VNTR) of the 5-HTT gene in 204 people aged over 60 derived from a random sample of men and women in the general population. Approximately half of the subjects were in the top 20% of neuroticism scorers and half in the bottom 20%.Results. There were no significant differences in allelic or genotypic frequencies between the high and low neuroticism scorers. There was highly significant linkage disequilibrium between the two 5-HTT gene polymorphisms, and haplotype analysis showed no association between neuroticism level and haplotype.Conclusions. Reports of an association between two 5-HTT gene polymorphisms and the personality trait of neuroticism are not supported by these results.

scholarly journals Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF

2010 ◽  
Vol 112 (1) ◽  
pp. 296-306 ◽  
Author(s):  
Fahad R. Ali ◽  
Sylvia A. Vasiliou ◽  
Kate Haddley ◽  
Ursula M. Paredes ◽  
Julian C. Roberts ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Tandem Repeats ◽  
Variable Number ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Variable Number Tandem Repeats

Intronic Tandem Repeat in the Serotonin Transporter Gene in Old World Monkeys: a New Transcriptional Regulator?

2011 ◽  
Vol 47 (2) ◽  
pp. 401-407 ◽  
Author(s):  
Ursula M. Paredes ◽  
Vivien J. Bubb ◽  
Kate Haddley ◽  
Gabriele A. Macho ◽  
John P. Quinn
Keyword(s):  
Serotonin Transporter ◽  
Tandem Repeat ◽  
Transcriptional Regulator ◽  
Serotonin Transporter Gene ◽  
Old World Monkeys ◽  
Transporter Gene ◽  
Old World
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