Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron

In the review it was characterized today existing biomarkers that allow to detect chronic alcohol abuse, namely: carbohydrate-deficient transferrin, the activity of GGT, ALT, AST, β-hexosaminidase; sialic acid index of apolipoprotein J, circulating levels of cytokines (TNF-α, IL-1 and IL-6), α-1- and α-2 globulins, serum amyloid A4, fibronectin, and others. At present results of the studies of alcohol abusers organism's proteome contain significant amount of artifacts, which are connected with the other substances of double abuse (e.g. cocaine, tobacco), specific nutrition deficiency, and the presence of organs dysfunction. Summarising the scientific literature analysis we can attest the lack of research concerning proteome changes at different stages of alcohol intoxication. An important task is to identify biomarkers that would allow measuring the level of alcohol consumption by detecting tissue damage and other physiological reactions on the alcohol abuse over time. Strategies of alcoholism biomarkers research should include the identification of proteins, which number differs in alcoholics and non-alcoholics. Decoding of individual proteome is likely to be part of the future personalized medicine.

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Accuracy of carbohydrate‐deficient transferrin (CDT) as a biomarker of chronic alcohol abuse during treatment for alcoholism

Hepatology Research ◽

10.1111/hepr.13642 ◽

2021 ◽

Author(s):

Tatsuya Suzuki ◽

Akiko Eguchi ◽

Ryuta Shigefuku ◽

Saeko Nagao ◽

Masayuki Morikawa ◽

...

Keyword(s):

Alcohol Abuse ◽

Chronic Alcohol ◽

Chronic Alcohol Abuse ◽

Carbohydrate Deficient Transferrin

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ADVANCED APPROACH TO DIAGNOSTICS OF CHRONIC ALCOHOL ABUSE

Science and Innovations in Medicine ◽

10.35693/2500-1388-2019-4-1-37-41 ◽

2019 ◽

Vol 4 (1) ◽

pp. 37-41

Author(s):

Sergei A. Tsarev ◽

Andrei V. Shcherban ◽

Sergei A. Suslin ◽

Aleksei A. Katin ◽

Il'ya I. Sirotko

Keyword(s):

Alcohol Abuse ◽

Drunk Driving ◽

Diagnostic Value ◽

Positive Test ◽

Test Results ◽

Chronic Alcohol ◽

Chronic Alcohol Abuse ◽

The Past ◽

Extensive Analysis ◽

Carbohydrate Deficient Transferrin

Objectives - to identify the criteria of selecting the applicants for professional drivers who require the carbohydrate-deficient transferrin (CDT) assay, which can be applied by an addiction psychiatrist. Material and methods. The extensive analysis of testing results of 232 patients admitted to Samara Regional Narcological Dispensary from its local subsidiaries in Samara and the Samara Region was carried out. Results. The fact of driving in drunk condition in the past was defined as the criterion having the diagnostic value. Conclusion. The patients with the known fact of drunk driving had the majority of positive test results of the chronic alcohol abuse, compared to other groups of patients in this study. These findings make it possible to declare the deprivation of driving license due to the drunk driving to be a valuable criterion to submit the applicant for the CDT assay during his qualifying as a driver.

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