Benefit of carbohydrate deficient transferrin in detecting chronic alcohol abuse in the elderly: study protocol for a multicentre, non-randomized, open-label study

2016 ◽  
Vol 1 (3) ◽  
pp. 121
Author(s):  
Cécile Schnell
Keyword(s):  
Alcohol Abuse ◽  
Study Protocol ◽  
The Elderly ◽  
Chronic Alcohol ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin

Open-Label Study to Evaluate the Healing Rate and Safety of the Profore™ Extra Four-Layer Bandage System in Patients with Venous Leg Ulceration

2000 ◽  
Vol 4 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Aditya K. Gupta ◽  
Joel De Koven ◽  
Robert Lester ◽  
Neil H. Shear ◽  
Daniel N. Sauder
Keyword(s):  
Healing Rate ◽  
The Elderly ◽  
Leg Ulcers ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Venous Leg Ulcers ◽  
Initial Event ◽  
Venous Ulcers ◽  
High Compression

Background: Venous ulcers are increasing in prevalence, especially since these are observed more frequently in the elderly, and the number of individuals in this age group is becoming a larger portion of the population. Objective: To determine the healing rate and safety of the Profore™ Extra Four-Layer Bandage System in the management of venous leg ulcers. Methods: In an open-label study, patients aged 18 years or older with venous leg ulcers were treated with a high compression four-layer bandage system in which a hydrocellular dressing was placed in contact with the wound. The combination is designated the “Profore Extra Four-Layer Bandage System.” Follow-up visits took place weekly unless there was heavy exudation from the ulcer or if there was marked edema of the leg at the start of the study requiring reapplication of the bandage system. Results: Fifteen patients were entered into the study (men 8, women 7, mean age 66 years, mean duration of ulcers 1.3 years). Thirteen of the 15 patients completed the study, with two withdrawals. In one patient who withdrew, the ulcer became infected and required treatment with antibiotics. The other termination from the study occurred for reasons unrelated to treatment. The ulcer in this patient healed in 7 weeks. Ten of the 13 patients (77%) who completed the study, and 10 (67%) of 15, who had enrolled experienced complete (100%) healing. Healing of > 80% of the ulcers occurred in 11 of 13 patients (85%) who completed the study and in 12 (80%) of 15 enrolled patients. No patient experienced a study-related adverse event. One patient developed contact dermatitis and was later found to have stasis dermatitis. It is unclear whether the initial event was contact or stasis dermatitis. Conclusion: In this open-label study, a high compression system, using the Profore Extra Four-Layer Bandage with a hydrocellular dressing in contact with the wound, was found to be effective and safe for the treatment of venous leg ulcers.

scholarly journals Analysis of protein profile changes in chronic alcohol intoxication to diagnose the development of these pathological conditions

2015 ◽  
Vol 70 (2) ◽  
pp. 11-19
Author(s):  
O. Harchenko ◽  
O. Savchuk ◽  
L. Ostapchenko
Keyword(s):  
Alcohol Abuse ◽  
Alcohol Intoxication ◽  
Protein Profile ◽  
Chronic Alcohol ◽  
Alcohol Abusers ◽  
Chronic Alcohol Abuse ◽  
Apolipoprotein J ◽  
Other Substances ◽  
Carbohydrate Deficient Transferrin ◽  
Proteome Changes

In the review it was characterized today existing biomarkers that allow to detect chronic alcohol abuse, namely: carbohydrate-deficient transferrin, the activity of GGT, ALT, AST, β-hexosaminidase; sialic acid index of apolipoprotein J, circulating levels of cytokines (TNF-α, IL-1 and IL-6), α-1- and α-2 globulins, serum amyloid A4, fibronectin, and others. At present results of the studies of alcohol abusers organism's proteome contain significant amount of artifacts, which are connected with the other substances of double abuse (e.g. cocaine, tobacco), specific nutrition deficiency, and the presence of organs dysfunction. Summarising the scientific literature analysis we can attest the lack of research concerning proteome changes at different stages of alcohol intoxication. An important task is to identify biomarkers that would allow measuring the level of alcohol consumption by detecting tissue damage and other physiological reactions on the alcohol abuse over time. Strategies of alcoholism biomarkers research should include the identification of proteins, which number differs in alcoholics and non-alcoholics. Decoding of individual proteome is likely to be part of the future personalized medicine.

Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron

1999 ◽  
Vol 11 (6) ◽  
pp. 687
Author(s):  
Tullia Maria De Feo ◽  
Silvia Fargion ◽  
Lorena Duca ◽  
Michela Mattioli ◽  
Maria Domenica Cappellini ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Chronic Alcohol ◽  
Body Iron ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin ◽  
Sensitive Marker

Accuracy of carbohydrate‐deficient transferrin (CDT) as a biomarker of chronic alcohol abuse during treatment for alcoholism

2021 ◽  
Author(s):  
Tatsuya Suzuki ◽  
Akiko Eguchi ◽  
Ryuta Shigefuku ◽  
Saeko Nagao ◽  
Masayuki Morikawa ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Chronic Alcohol ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin

scholarly journals ADVANCED APPROACH TO DIAGNOSTICS OF CHRONIC ALCOHOL ABUSE

2019 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Sergei A. Tsarev ◽  
Andrei V. Shcherban ◽  
Sergei A. Suslin ◽  
Aleksei A. Katin ◽  
Il'ya I. Sirotko
Keyword(s):  
Alcohol Abuse ◽  
Drunk Driving ◽  
Diagnostic Value ◽  
Positive Test ◽  
Test Results ◽  
Chronic Alcohol ◽  
Chronic Alcohol Abuse ◽  
The Past ◽  
Extensive Analysis ◽  
Carbohydrate Deficient Transferrin

Objectives - to identify the criteria of selecting the applicants for professional drivers who require the carbohydrate-deficient transferrin (CDT) assay, which can be applied by an addiction psychiatrist. Material and methods. The extensive analysis of testing results of 232 patients admitted to Samara Regional Narcological Dispensary from its local subsidiaries in Samara and the Samara Region was carried out. Results. The fact of driving in drunk condition in the past was defined as the criterion having the diagnostic value. Conclusion. The patients with the known fact of drunk driving had the majority of positive test results of the chronic alcohol abuse, compared to other groups of patients in this study. These findings make it possible to declare the deprivation of driving license due to the drunk driving to be a valuable criterion to submit the applicant for the CDT assay during his qualifying as a driver.

Sign in / Sign up

Export Citation Format

Share Document