Validity of carbohydrate-deficient transferrin (%CDT), γ-glutamyltransferase (γ-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin

Addiction ◽  
2005 ◽  
Vol 100 (10) ◽  
pp. 1477-1486 ◽  
Author(s):  
B. Hock ◽  
M. Schwarz ◽  
I. Domke ◽  
V. P. Grunert ◽  
M. Wuertemberger ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Alcohol Dependence ◽  
Chronic Alcohol ◽  
Liver Disorders ◽  
Erythrocyte Volume ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin

scholarly journals Analysis of protein profile changes in chronic alcohol intoxication to diagnose the development of these pathological conditions

2015 ◽  
Vol 70 (2) ◽  
pp. 11-19
Author(s):  
O. Harchenko ◽  
O. Savchuk ◽  
L. Ostapchenko
Keyword(s):  
Alcohol Abuse ◽  
Alcohol Intoxication ◽  
Protein Profile ◽  
Chronic Alcohol ◽  
Alcohol Abusers ◽  
Chronic Alcohol Abuse ◽  
Apolipoprotein J ◽  
Other Substances ◽  
Carbohydrate Deficient Transferrin ◽  
Proteome Changes

In the review it was characterized today existing biomarkers that allow to detect chronic alcohol abuse, namely: carbohydrate-deficient transferrin, the activity of GGT, ALT, AST, β-hexosaminidase; sialic acid index of apolipoprotein J, circulating levels of cytokines (TNF-α, IL-1 and IL-6), α-1- and α-2 globulins, serum amyloid A4, fibronectin, and others. At present results of the studies of alcohol abusers organism's proteome contain significant amount of artifacts, which are connected with the other substances of double abuse (e.g. cocaine, tobacco), specific nutrition deficiency, and the presence of organs dysfunction. Summarising the scientific literature analysis we can attest the lack of research concerning proteome changes at different stages of alcohol intoxication. An important task is to identify biomarkers that would allow measuring the level of alcohol consumption by detecting tissue damage and other physiological reactions on the alcohol abuse over time. Strategies of alcoholism biomarkers research should include the identification of proteins, which number differs in alcoholics and non-alcoholics. Decoding of individual proteome is likely to be part of the future personalized medicine.

Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron

1999 ◽  
Vol 11 (6) ◽  
pp. 687
Author(s):  
Tullia Maria De Feo ◽  
Silvia Fargion ◽  
Lorena Duca ◽  
Michela Mattioli ◽  
Maria Domenica Cappellini ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Chronic Alcohol ◽  
Body Iron ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin ◽  
Sensitive Marker

Accuracy of carbohydrate‐deficient transferrin (CDT) as a biomarker of chronic alcohol abuse during treatment for alcoholism

2021 ◽  
Author(s):  
Tatsuya Suzuki ◽  
Akiko Eguchi ◽  
Ryuta Shigefuku ◽  
Saeko Nagao ◽  
Masayuki Morikawa ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Chronic Alcohol ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin

scholarly journals ADVANCED APPROACH TO DIAGNOSTICS OF CHRONIC ALCOHOL ABUSE

2019 ◽  
Vol 4 (1) ◽  
pp. 37-41
Author(s):  
Sergei A. Tsarev ◽  
Andrei V. Shcherban ◽  
Sergei A. Suslin ◽  
Aleksei A. Katin ◽  
Il'ya I. Sirotko
Keyword(s):  
Alcohol Abuse ◽  
Drunk Driving ◽  
Diagnostic Value ◽  
Positive Test ◽  
Test Results ◽  
Chronic Alcohol ◽  
Chronic Alcohol Abuse ◽  
The Past ◽  
Extensive Analysis ◽  
Carbohydrate Deficient Transferrin

Objectives - to identify the criteria of selecting the applicants for professional drivers who require the carbohydrate-deficient transferrin (CDT) assay, which can be applied by an addiction psychiatrist. Material and methods. The extensive analysis of testing results of 232 patients admitted to Samara Regional Narcological Dispensary from its local subsidiaries in Samara and the Samara Region was carried out. Results. The fact of driving in drunk condition in the past was defined as the criterion having the diagnostic value. Conclusion. The patients with the known fact of drunk driving had the majority of positive test results of the chronic alcohol abuse, compared to other groups of patients in this study. These findings make it possible to declare the deprivation of driving license due to the drunk driving to be a valuable criterion to submit the applicant for the CDT assay during his qualifying as a driver.

scholarly journals Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and Interpretation

2001 ◽  
Vol 47 (1) ◽  
pp. 13-27 ◽  
Author(s):  
Torsten Arndt
Keyword(s):  
Alcohol Abuse ◽  
Human Serum ◽  
Current Knowledge ◽  
Specific Marker ◽  
Diagnostic Efficiency ◽  
Chronic Alcohol ◽  
Statistical Parameters ◽  
Chronic Alcohol Abuse ◽  
Carbohydrate Deficient Transferrin

Abstract Background: Carbohydrate-deficient transferrin (CDT) is used for diagnosis of chronic alcohol abuse. Some 200–300 reports on CDT have been published in impact factor-listed journals. The aims of this review were to condense the current knowledge and to resolve remaining issues on CDT. Approach: The literature (1976–2000) was searched using MEDLINE and Knowledge Server with “alcohol and CDT” as the search items. The data were reviewed systematically, checked for redundancy, and organized in sequence based on the steps involved in CDT analysis. Content: The review is divided into sections based on microheterogeneity of human serum transferrin (Tf), definition of CDT, structure of human serum CDT, pathomechanisms of ethanol-induced CDT increase, preanalysis, analysis, and medical interpretation (postanalysis). Test-specific cutoff values for serum CDT and causes of false positives and negatives for chronic alcohol abuse are discussed and summarized. Summary: Asialo- and disialo-Fe2-Tf, which lack one or two complete N-glycans, and monosialo-Fe2-Tf (structure remains unclear) are collectively referred to as CDT. Diminished mRNA concentration and glycoprotein glycosyltransferase activities involved in Tf N-glycan synthesis and increased sialidase activity most likely account for alcohol-induced increases in CDT. Knowledge about in vivo and in vitro effects on serum CDT is poor. Reliable CDT and non-CDT fractionation is needed for CDT measurement. Analysis methods with different analytical specificities and recoveries decreased the comparability of values and statistical parameters of the diagnostic efficiency of CDT. CDT is the most specific marker of chronic alcohol abuse to date. Efforts should concentrate on the pathomechanisms (in vivo), preanalysis, and standardization of CDT analysis.

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