Thyroid hormone receptor isoforms, nuclear corepressors and coactivators, and their role in thyroid hormone action

1998 ◽  
Vol 5 (4) ◽  
pp. 314-320 ◽  
Author(s):  
Anthony N. Hollenberg
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hormone Action ◽  
Thyroid Hormone Action ◽  
Receptor Isoforms ◽  
Nuclear Corepressors

Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action

2003 ◽  
Vol 284 (1) ◽  
pp. E36-E46 ◽  
Author(s):  
Peter M. Sadow ◽  
Olivier Chassande ◽  
Karine Gauthier ◽  
Jacques Samarut ◽  
Jianming Xu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Steroid Receptor ◽  
Receptor Subtype ◽  
Thyroid Function Tests ◽  
Hormone Action ◽  
Peripheral Tissues ◽  
Steroid Receptor Coactivator ◽  
Thyroid Hormone Action

Isoforms of the thyroid hormone receptor ( TR) α and TRβ genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear receptor superfamily, and modulate the activity of genes regulated by TH. Mice deficient in SRC-1 possess decreased tissue responsiveness to TH and many steroid hormones; however, it is not known whether or not SRC-1-mediated activation of TH-regulated gene transcription in peripheral tissues, such as heart and liver, is TR isoform specific. We have generated mice deficient in TRα and SRC-1, as well as in TRβ and SRC-1, and investigated thyroid function tests and effects of TH deprivation and TH treatment compared with wild-type (WT) mice or those deficient in either TR or SRC-1 alone. The data show that 1) in the absence of TRα or TRβ, SRC-1 is important for normal growth; 2) SRC-1 modulates TRα and TRβ effects on heart rate; 3) two new TRβ-dependent markers of TH action in the liver have been identified, osteopontin (upregulated) and glutathione S-transferase (downregulated); and 4) SRC-1 may mediate the hypersensitivity to TH seen in liver of TRα-deficient mice.

scholarly journals Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo

2003 ◽  
Vol 112 (4) ◽  
pp. 588-597 ◽  
Author(s):  
Nobuyuki Shibusawa ◽  
Koshi Hashimoto ◽  
Amisra A. Nikrodhanond ◽  
M. Charles Liberman ◽  
Meredithe L. Applebury ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Dna Binding ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hormone Action ◽  
Thyroid Hormone Action

scholarly journals A Direct Comparison of Thyroid Hormone Receptor Protein Levels in Mice Provides Unexpected Insights into Thyroid Hormone Action

Thyroid ◽  
2020 ◽  
Vol 30 (8) ◽  
pp. 1193-1204 ◽  
Author(s):  
Svetlana Minakhina ◽  
Sanya Bansal ◽  
Alice Zhang ◽  
Michael Brotherton ◽  
Rucha Janodia ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Protein ◽  
Hormone Action ◽  
Protein Levels ◽  
Thyroid Hormone Action

Coexpression of thyroid hormone receptor isoforms in mouse oligodendrocytes

2001 ◽  
Vol 67 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Fabienne Bury ◽  
Jean-Luc Carré ◽  
Sonia Vega ◽  
M. Said Ghandour ◽  
Angeles Rodriguez-Peña ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Isoforms
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