The Efficacy of Tranexamic Acid Versus Placebo in Decreasing Blood Loss in Pediatric Patients Undergoing Repeat Cardiac Surgery

1998 ◽  
Vol 42 (3) ◽  
pp. 146
Author(s):  
ROBERT W. REID ◽  
A. ANDREW ZIMMERMAN ◽  
PETER C. LAUSSEN ◽  
JOHN E. MAYER ◽  
JED B. GORLIN ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Pediatric Patients ◽  
Acid Versus

The Efficacy of Tranexamic Acid Versus Placebo in Decreasing Blood Loss in Pediatric Patients Undergoing Repeat Cardiac Surgery

1997 ◽  
Vol 84 (5) ◽  
pp. 990-996 ◽  
Author(s):  
Robert W. Reid ◽  
A. Andrew Zimmerman ◽  
Peter C. Laussen ◽  
John E. Mayer ◽  
Jed B. Gorlin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Pediatric Patients ◽  
Acid Versus

scholarly journals The Efficacy of Tranexamic Acid Versus Placebo in Decreasing Blood Loss in Pediatric Patients Undergoing Repeat Cardiac Surgery

1997 ◽  
Vol 84 (5) ◽  
pp. 990-996 ◽  
Author(s):  
Robert W. Reid ◽  
A. Andrew Zimmerman ◽  
Peter C. Laussen ◽  
John E. Mayer ◽  
Jed B. Gorlin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Pediatric Patients ◽  
Acid Versus

Hemostatic Parameters and Platelet Activation Marker Expression in Cyanotic and Acyanotic Pediatric Patients Undergoing Cardiac Surgery in the Presence of Tranexamic Acid

2000 ◽  
Vol 83 (01) ◽  
pp. 54-59 ◽  
Author(s):  
Elena Levin ◽  
John Wu ◽  
John Alexander ◽  
Clayton Reichart ◽  
Suvro Sett ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Activation ◽  
Pediatric Patients ◽  
Factor Xiiia ◽  
Congenital Defects ◽  
Plasma Factor ◽  
Pai 1 ◽  
D Dimer

SummaryWe have investigated hemostatic parameters including platelet activation in 56 pediatric patients with or without cyanosis undergoing cardiopulmonary bypass (CPB) and cardiac surgery to repair congenital defects. Patients were participants in a study assessing the effects of tranexamic acid on surgery-related blood loss. Parameters monitored included blood loss, prothrombin F1.2, thrombin-antithrombin complexes, t-PA, PAI-1, plasminogen, fibrin D-dimer, and plasma factor XIII. Additionally, flow cytometry monitored platelet degranulation (P-selectin or CD63), as well as surface-bound fibrinogen, von Willebrand factor and factor XIIIa. Cyanotic patients had evidence of supranormal coagulation activation as both fibrin D-dimer and PAI-1 levels were elevated prior to surgery. While the extent of expression of Pselectin or CD63 was not informative, platelet-associated factor XIIIa was elevated in cyanotic patients at baseline. In both patient groups, CPB altered platelet activation state and coagulation status irrespective of the use of tranexamic acid.

scholarly journals Effect of Tranexamic Acid after Cardiac Surgery in Children

1970 ◽  
Vol 1 (2) ◽  
pp. 189-192
Author(s):  
MK Hassan ◽  
KA Hasan ◽  
ABMA Salam ◽  
A Razzak ◽  
S Ferdous ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Pediatric Patients ◽  
Acid Group ◽  
Skin Incision ◽  
Total Blood Loss ◽  
Financial Cost ◽  
Total Blood ◽  
Transfusion Requirements

Background: The antifibrinolytic drug tranexamic acid (TA) decreases blood loss in Pediatric patients under going cardiac Surgery. However its efficacy has not been extensively studied in children. Method: We examined 750 children under going cardiac surgery form 2004 to 2007 in National Institute of Cardiovascular Diseases (NICVD), 379 children in the Tranexamic Acid group (TA) and 371 included in placebo (P) group. After induction of anesthesia and prior to skin incision, patients received either tranexamic acid (10mg/kg followed by 1mg/kg/hr) and saline placebo. After admission to intensive care unit total blood loss and transfusion requirements during the first12 hours were recorded. Result: Children who were treated with tranexamic acid had 24% less total blood loss (26±7 vs 34±17 ml/kg) compared with children who received placebo (p<0.05). Additionally, the total transfusion requirements, total donor unit exposure and financial cost of blood components were less in the tranexamic acid group. Conclusion: Tranexamic acid can reduce perioperative blood loss in children undergoing cardiac surgery.Keywords: Tranexemic acid; Cardiac surgery; Post operative; bleeding DOI: http://dx.doi.org/10.3329/cardio.v1i2.8127 Cardiovasc. j. 2009; 1(2) : 189-192

The Influence of Aprotinin and Tranexamic Acid on Platelet Function and Postoperative Blood Loss in Cardiac Surgery

2008 ◽  
Vol 107 (2) ◽  
pp. 391-397 ◽  
Author(s):  
Andinet M. Mengistu ◽  
Kerstin D. Röhm ◽  
Joachim Boldt ◽  
Jochen Mayer ◽  
Stefan W. Suttner ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Function ◽  
Postoperative Blood Loss

The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32°C)

1998 ◽  
Vol 12 (6) ◽  
pp. 642-646 ◽  
Author(s):  
Jacek M. Karski ◽  
Noreen P. Dowd ◽  
Ross Joiner ◽  
Jo Carroll ◽  
Charles Peniston ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Systemic Hypothermia ◽  
Different Doses
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