Role of peroxisome proliferator-activated receptor-γ in the protection afforded by 15-deoxyΔ12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin

2004 ◽  
Vol 32 (3) ◽  
pp. 826-831 ◽  
Author(s):  
Marika Collin ◽  
Nimesh S. A. Patel ◽  
Laura Dugo ◽  
Christoph Thiemermann
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Prostaglandin J2

Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis

2007 ◽  
Vol 42 (3) ◽  
pp. 454-461 ◽  
Author(s):  
Renu Sharma ◽  
Joseph J. Tepas ◽  
Mark L. Hudak ◽  
Daniel L. Mollitt ◽  
Peter S. Wludyka ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Necrotizing Enterocolitis ◽  
Proinflammatory Cytokines ◽  
Multiple Organ ◽  
Gut Barrier

Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome

2003 ◽  
Vol 31 (4) ◽  
pp. 1048-1052 ◽  
Author(s):  
Takeshi Motoyama ◽  
Kazufumi Okamoto ◽  
Ichirou Kukita ◽  
Masamichi Hamaguchi ◽  
Yoshihiro Kinoshita ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Oxidant Stress ◽  
Multiple Organ ◽  
Systemic Inflammatory Response

scholarly journals 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

PPAR Research ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jingjing Li ◽  
Chuanyong Guo ◽  
Jianye Wu
Keyword(s):  
Peroxisome Proliferator ◽  
Defence Mechanism ◽  
Endogenous Ligand ◽  
Peroxisome Proliferator Activated Receptor ◽  
Associated Diseases ◽  
Ppar Γ ◽  
Structure Synthesis ◽  
Functional Mechanisms ◽  
Prostaglandin J2

15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.

POST-INJURY MULTIPLE ORGAN FAILURE: THE ROLE OF THE GUT

Shock ◽  
2001 ◽  
Vol 15 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Heitham T. Hassoun ◽  
Bruce C. Kone ◽  
David W. Mercer ◽  
Frank G. Moody ◽  
Norman W. Weisbrodt ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Post Injury

scholarly journals Role of PPAR-δ in the development of zymosan-induced multiple organ failure: an experiment mice study

2010 ◽  
Vol 7 (1) ◽  
pp. 12 ◽  
Author(s):  
Maria Galuppo ◽  
Rosanna Di Paola ◽  
Emanuela Mazzon ◽  
Tiziana Genovese ◽  
Concetta Crisafulli ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ

scholarly journals ROLE OF NITRIC OXIDE ON MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 70-71
Author(s):  
Salvatore Cuzzocrea ◽  
Basilia Zingarelli ◽  
Lydia Sautebin ◽  
Massimo Di Rosa ◽  
Achille P. Caputi
Keyword(s):  
Nitric Oxide ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ
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