Transrectal ultrasound-guided needle biopsy of the prostate (TRUS)is a well-tolerated and standardized procedure for the diagnosisof prostate cancer. Complications associated with TRUS requiringemergency room visits or hospital admissions are relatively low andinclude complications, such as a 1% risk of urinary retention andless than 1% chance of bacterial sepsis. Vertebral osteomyelitis isa rare complication of TRUS; there are 3 reported cases. Vertebralosteomyelitis has an insidious onset and usually resolves followingmedical intervention. We present an extremely rare case ofvertebral osteomyelitis following TRUS, its clinical outcome andmanagement.