scholarly journals 185: PREVALENCE OF BACTERIAL AND FUNGAL COINFECTIONS IN A COVID-19 AUTOPSY CASE SERIES

2021 ◽  
Vol 50 (1) ◽  
pp. 76-76
Author(s):  
Andrew Platt ◽  
Nadia Nasir ◽  
Bradley Ben ◽  
Sydney Stein ◽  
Sabrina Ramelli ◽  
...  
Keyword(s):  
Case Series ◽  
Autopsy Case

The Neuropathology of 1p36 Deletion Syndrome: An Autopsy Case Series

2021 ◽  
Author(s):  
Kyle S Conway ◽  
Fozia Ghafoor ◽  
Amy C Gottschalk ◽  
Joseph Laakman ◽  
Renee L Eigsti ◽  
...  
Keyword(s):  
Neuronal Migration ◽  
Single Case ◽  
Case Reports ◽  
Case Series ◽  
Deletion Syndrome ◽  
Cerebellar Hypoplasia ◽  
Autopsy Case ◽  
Single Case Report ◽  
Renal Abnormalities

Abstract 1p36 deletion syndrome is the most common terminal deletion syndrome, manifesting clinically as abnormal facies and developmental delay with frequent cardiac, skeletal, urogenital, and renal abnormalities. Limited autopsy case reports describe the neuropathology of 1p36 deletion syndrome. The most extensive single case report described a spectrum of abnormalities, mostly related to abnormal neuronal migration. We report the largest published series of 1p36 autopsy cases, with an emphasis on neuropathologic findings. Our series consists of 3 patients: 2 infants (5-hours old and 23-days old) and 1 older child (11 years). Our patients showed abnormal cortical gyration together with a spectrum of neuronal migration abnormalities, including heterotopias and hippocampal abnormalities, as well as cerebellar hypoplasia. Our findings thus support the role of neuronal migration defects in the pathogenesis of cognitive defects in 1p36 deletion syndrome and broaden the reported neuropathologic spectrum of this common syndrome.

Characteristic Distribution of Inflammatory Lesions in IgG4-Related Kidney Disease: Findings from Autopsy Case Series

2016 ◽  
pp. 187-191
Author(s):  
Satoshi Hara ◽  
Mitsuhiro Kawano ◽  
Ichiro Mizushima ◽  
Kenichi Harada ◽  
Takuma Takata ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Case Series ◽  
Autopsy Case ◽  
Inflammatory Lesions ◽  
Characteristic Distribution

Perinatal Pulmonary Hemorrhage: A Retrospective Autopsy Case Series

2020 ◽  
Vol 23 (4) ◽  
pp. 267-273
Author(s):  
Indu Agarwal ◽  
Linda M Ernst
Keyword(s):  
Pulmonary Hypoplasia ◽  
Case Series ◽  
Pulmonary Hemorrhage ◽  
Vascular Pathology ◽  
Placental Pathology ◽  
Autopsy Case ◽  
Inclusion Criteria ◽  
High Prevalence ◽  
Hematoxylin And Eosin ◽  
Pathology Reports

Perinatal pulmonary hemorrhage (PH) is a condition characterized by blood loss via the respiratory tract with an approximate incidence of 0.1% in all newborns. The histologic characteristics of the lung in PH are not well characterized, and we hypothesized that pulmonary maldevelopment such as pulmonary hypoplasia may contribute to PH. In addition, we sought to find any correlations with placental pathology. Retrospective study of fetal and neonatal autopsies with diagnosis of PH was performed between the years from 2009 to 2015. Autopsy reports, placental pathology reports, and hematoxylin and eosin sections of the lung were reviewed. Of the 17 cases which were identified meeting inclusion criteria, PH ranged from mild (<5% in each lung) to severe (>75% in both lungs). PH involved >50% of both lungs in 6 cases. Pulmonary hypoplasia was designated in 7 of 17 (41.17%) cases with PH. Pulmonary hypoplasia and/or persistence of intra-acinar arterioles was seen in 13 of 17 (76.4%) cases. No specific placental pathology was seen universally in the cases of PH, but either maternal or fetal vascular malperfusion was noted in 14 of 17 (82%) cases. Our data suggest a high prevalence of pulmonary maldevelopment, such as pulmonary hypoplasia and persistence of intra-acinar arterioles, in cases with PH. Although no specific placental pathology is seen in PH, maternal and fetal vascular pathology is common.

Homicide and concealment of the corpse. Autopsy case series and review of the literature

2020 ◽  
Vol 135 (1) ◽  
pp. 193-205
Author(s):  
Maria De Matteis ◽  
Arianna Giorgetti ◽  
Guido Viel ◽  
Chiara Giraudo ◽  
Claudio Terranova ◽  
...  
Keyword(s):  
Case Series ◽  
Autopsy Case ◽  
Review Of The Literature

The WHO/START study in New Caledonia: A psychological autopsy case series

2020 ◽  
Vol 262 ◽  
pp. 366-372
Author(s):  
Benjamin Goodfellow ◽  
Kairi Kõlves ◽  
Anne-Cécile Selefen ◽  
Tiffany Massain ◽  
Stéphane Amadéo ◽  
...  
Keyword(s):  
New Caledonia ◽  
Case Series ◽  
Autopsy Case ◽  
Psychological Autopsy

Co-morbidities associated with tuberculosis in an autopsy case series

Tuberculosis ◽  
2011 ◽  
Vol 91 ◽  
pp. S38-S42 ◽  
Author(s):  
Elena Sbrana ◽  
Joy Grise ◽  
Clarke Stout ◽  
Judith Aronson
Keyword(s):  
Case Series ◽  
Autopsy Case

scholarly journals Evaluation of Selection Bias in an Incident-Based Dementia Autopsy Case Series

2005 ◽  
Vol 19 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Debby Tsuang ◽  
Kate L Simpson ◽  
Gail Li ◽  
Ross L Barnhart ◽  
Steven D Edland ◽  
...  
Keyword(s):  
Selection Bias ◽  
Case Series ◽  
Autopsy Case

Detection of Pulmonary Platelet Thrombi in Acute Chest Syndrome in Sickle Cell Disease: Novel Findings in an Autopsy Case Series

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4093-4093
Author(s):  
Ciprian Anea ◽  
Amidat Adeyemi ◽  
Itia Lee ◽  
Kavita Natrajan ◽  
Greer Falls ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Medical Record ◽  
Sickle Cell ◽  
Acute Pain ◽  
Case Series ◽  
Acute Chest Syndrome ◽  
Autopsy Case ◽  
Cell Disease ◽  
Autopsy Report ◽  
Platelet Thrombi

Abstract Introduction: Acute chest syndrome (ACS) is one of the leading causes of death in patients with sickle cell disease (SCD). The pulmonary manifestations of ACS often appear suddenly and can progress rapidly to fatality. There are multiple identified etiologies associated with the development of ACS including infection, fat or pulmonary embolism, and opiate intoxication. The cause cannot be attributed to a single agent in most cases and if so, is likely determined authoritatively only at autopsy. One potential commonality, however, is that an acute pain event usually precedes the onset of ACS. Although, clearly there remains much to be learned, acute pain events are one of the better characterized aspects of SCD. In most cases, there is an increase in inflammatory markers and indicators of endothelial dysfunction. Platelet activation increases during pain events, as do platelet-derived markers of inflammation. In fact, platelets are emerging as potentially pivotal contributors to the overall inflammatory state of patients. Although patients at steady state typically have high platelet counts, platelet count decrease during pain events. Overt thrombocytopenia has been noted in ACS and is usually attributed to platelet sequestration in the vasculature. Thus, we considered the platelet to be a potential contributor to pulmonary pathology in cases of ACS. To lend support to our hypothesis, we performed an autopsy study of pulmonary histology in patients with SCD and ACS. Objective: To interrogate whether platelet thrombi were significant findings in lungs of patients who died concurrent with ACS. Methods: We performed an autopsy case series. Ten autopsies and corresponding medical records from patients with SCD were selected from those conducted at Georgia Regents Medical Center from 1997-2013. From the medical record or autopsy report, all cases had ACS listed concurrent with or as the primary cause of death. No pediatric cases were included in the series (age range 18-45 years old). Paraffin-embedded lung samples were obtained from all cases. Standard immunohistochemical techniques were used to detect platelet thrombi. A comprehensive perimortem medical record was available for 8 patients. A genotype of either SS or S/β0-Thalassemia was acceptable. Two cases were recorded with an S/β0-Thalassemia genotype, the rest were listed as SS. Results: Profound arterial platelet thrombi were detected in 3 out of the 10 cases. In these 3 positive cases, arterial vessels of all size (large arterial vessels to arterioles) were completely occluded by platelets. All platelet positive cases had a genotype of SS. In 2 of the 3 platelet thrombi positive cases, none of the established causes of ACS were noted in the medical record or autopsy report. In 1 platelet positive case, lipid-laden macrophages and ascites were noted at autopsy. Extensive pulmonary artery remodeling was noted in all 10 cases regardless of age or medical history. Conclusions: This case series illustrates that platelet- rich arterial thrombi are present in potentially up to 33 percent of fatal cases of ACS. These data are thus suggestive of a novel pathological role for platelets in ACS. Disclosures Kutlar: NIH/NIMHD: Research Funding.

O1-04-01: Visual hallucinations and Lewy body pathology: A community-based autopsy case series

2006 ◽  
Vol 2 ◽  
pp. S14-S15
Author(s):  
Debby Tsuang ◽  
Eric B. Larson ◽  
Elaine R. Peskind ◽  
James B. Bowen ◽  
Wayne McCormick ◽  
...  
Keyword(s):  
Lewy Body ◽  
Case Series ◽  
Visual Hallucinations ◽  
Autopsy Case ◽  
Community Based ◽  
Lewy Body Pathology
Sign in / Sign up

Export Citation Format

Share Document