230: RARE POST-COVID-19 SEQUELAE: A CASE SERIES ON NEW-ONSET TEMPORAL LOBE SEIZURES IN HEALTHY ADULTS

Electroencephalography (EEG) is an important tool for diagnosing, lateralizing and localizing temporal lobe seizures. In this paper, we review the EEG characteristics of temporal lobe epilepsy (TLE). Several “non-standard” electrodes may be needed to further evaluate the EEG localization, Ictal EEG recording is a major component of preoperative protocols for surgical consideration. Various ictal rhythms have been described including background attenuation, start-stop-start phenomenon, irregular 2-5 Hz lateralized activity, and 5-10 Hz sinusoidal waves or repetitive epileptiform discharges. The postictal EEG can also provide valuable lateralizing information. Postictal delta can be lateralized in 60% of patients with TLE and is concordant with the side of seizure onset in most patients. When patients are being considered for resective surgery, invasive EEG recordings may be needed. Accurate localization of the seizure onset in these patients is required for successful surgical management.

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Mechanisms in Temporal Lobe Seizures

Archives of Neurology ◽

10.1001/archneur.1961.00450130038006 ◽

1961 ◽

Vol 5 (1) ◽

pp. 36-45 ◽

Cited By ~ 7

Author(s):

R. J. STROBOS

Keyword(s):

Temporal Lobe ◽

Temporal Lobe Seizures

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Suspected new-onset autoimmune temporal lobe epilepsy with amygdala enlargement

Epilepsia ◽

10.1111/epi.13471 ◽

2016 ◽

Vol 57 (9) ◽

pp. 1485-1494 ◽

Cited By ~ 24

Author(s):

Michael P. Malter ◽

Guido Widman ◽

Norbert Galldiks ◽

Winfried Stoecker ◽

Christoph Helmstaedter ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

New Onset

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Case series: COVID-19 infection causing new-onset diabetes mellitus?

Endocrinology&Metabolism International Journal ◽

10.15406/emij.2021.09.00302 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Rujuta Katkar ◽

Narasa Raju Madam

Keyword(s):

Diabetes Mellitus ◽

Severe Acute Respiratory Syndrome ◽

Cell Damage ◽

Small Sample Size ◽

Case Series ◽

Small Sample ◽

Onset Diabetes ◽

History Of ◽

New Onset Diabetes Mellitus ◽

New Onset

Objectives: This paper seeks to explore the hypothesis of the potential diabetogenic effect of SARS-COV-2 (Severe Acute respiratory syndrome coronavirus). Case series presentation: We present a case series of observation among 8 patients of age group ranging from 34 to 74 years with a BMI range of 26.61 to 53.21 Kilogram/square meters that developed new-onset diabetes after COVID-19 infection. Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2), commonly known as Coronavirus or COVID-19(Coronavirus infectious disease), gains entry into the cells by binding to the Angiotensin-converting enzyme-2(ACE-2) receptors located in essential metabolic tissues including the pancreas, adipose tissue, small intestine, and kidneys. The evidence reviewed from the scientific literature describes how ACE 2 receptors play a role in the pathogenesis of diabetes and the plausible interaction of SARS-COV-2 with ACE 2 receptors in metabolic organs and tissues. Conclusion: The 8 patients without a past medical history of diabetes admitted with COVID-19 infection developed new-onset diabetes mellitus due to plausible interaction of SARS-COV-2 with ACE 2 receptors. The resulting downregulation of ACE-2 and ACE-2 receptors expression caused islet-cell damage resulting into diabetes. The resulting observation has the potential to adversely impact significant number of the globally affected population. Screening patients with COVID-19 for diabetes routinely can help in early detection, significantly reducing morbidity and mortality associated with diabetes. Due to limitations of observational study with a small sample size will require further investigation in the form of Clinical trial.

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Scalp-Recorded Auditory P300 Event-Related Potentials in New-Onset Untreated Temporal Lobe Epilepsy

Clinical EEG and Neuroscience ◽

10.1177/155005940703800314 ◽

2007 ◽

Vol 38 (3) ◽

pp. 168-171 ◽

Cited By ~ 9

Author(s):

Wuttichai V. Chayasirisobhon ◽

Sirichai Chayasirisobhon ◽

Sue Nwe Tin ◽

Ngoc Leu ◽

Keo Tehrani ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Hippocampal Sclerosis ◽

Event Related Potentials ◽

Auditory Event ◽

Auditory P300 ◽

Related Potentials ◽

Auditory Erps ◽

Auditory Event Related Potentials ◽

New Onset

We studied scalp-recorded auditory event-related potentials (ERPs) of 30 untreated patients with new-onset temporal lobe epilepsy and 30 age-and sex-matched normal controls. This study was designed to eliminate the effects of intractability of seizures and chronic use of antiepileptic drugs on P300 auditory ERPs. There were no statistically significant differences in both latency and amplitude of P300 between the two groups. Similar methods were also used to analyze component latencies and amplitudes of ERPs of 9 patients who had hippocampal sclerosis with comparison to control subjects. There were no statistically significant differences between these two groups as well. Our study evidently does not support temporal lobe sources of P300 scalp-recorded auditory ERPs. We also conclude that the scalp-recorded auditory ERPs procedure is not a useful tool to evaluate temporal lobe epilepsy.

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