Safety and Tolerability of Methylphenidate in Preschool Children With ADHD

Author(s):  
TIM WIGAL ◽  
LAURENCE GREENHILL ◽  
SHIRLEY CHUANG ◽  
JAMES McGOUGH ◽  
BENEDETTO VITIELLO ◽  
...  
2018 ◽  
Vol 57 (10) ◽  
pp. S165-S166
Author(s):  
Ann Catherine Childress ◽  
Scott H. Kollins ◽  
James Wu ◽  
Brigitte Robertson

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Katja Becker ◽  
Tobias Banaschewski ◽  
Daniel Brandeis ◽  
Christina Dose ◽  
Christopher Hautmann ◽  
...  

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a psychosocially impairing and cost-intensive mental disorder, with first symptoms occurring in early childhood. It can usually be diagnosed reliably at preschool age. Early detection of children with ADHD symptoms and an early, age-appropriate treatment are needed in order to reduce symptoms, prevent secondary problems and enable a better school start. Despite existing ADHD treatment research and guideline recommendations for the treatment of ADHD in preschool children, there is still a need to optimise individualised treatment strategies in order to improve outcomes. Therefore, the ESCApreschool study (Evidence-Based, Stepped Care of ADHD in Preschool Children aged 3 years and 0 months to 6 years and 11 months of age (3;0 to 6;11 years) addresses the treatment of 3–6-year-old preschool children with elevated ADHD symptoms within a large multicentre trial. The study aims to investigate the efficacy of an individualised stepwise-intensifying treatment programme. Methods The target sample size of ESCApreschool is 200 children (boys and girls) aged 3;0 to 6;11 years with an ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) or a diagnosis of oppositional defiant disorder (ODD) plus additional substantial ADHD symptoms. The first step of the adaptive, stepped care design used in ESCApreschool consists of a telephone-assisted self-help (TASH) intervention for parents. Participants are randomised to either the TASH group or a waiting control group. The treatment in step 2 depends on the outcome of step 1: TASH responders without significant residual ADHD/ODD symptoms receive booster sessions of TASH. Partial or non-responders of step 1 are randomised again to either parent management and preschool teacher training or treatment as usual. Discussion The ESCApreschool trial aims to improve knowledge about individualised treatment strategies for preschool children with ADHD following an adaptive stepped care approach, and to provide a scientific basis for individualised medicine for preschool children with ADHD in routine clinical care. Trial registration The trial was registered at the German Clinical Trials Register (DRKS) as a Current Controlled Trial under DRKS00008971 on 1 October 2015. This manuscript is based on protocol version 3 (14 October 2016).


2009 ◽  
Vol 13 (5) ◽  
pp. 479-488 ◽  
Author(s):  
Chaya Gopin ◽  
Dione Healey ◽  
Katia Castelli ◽  
David Marks ◽  
Jeffrey M. Halperin

2008 ◽  
Vol 29 (5) ◽  
pp. 403-411 ◽  
Author(s):  
Kevin M. Antshel ◽  
Robert Nastasi

2017 ◽  
Vol 49 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Katie C. Hart ◽  
Rosmary Ros ◽  
Victoria Gonzalez ◽  
Paulo A. Graziano

Author(s):  
Mokhtar Malekpour ◽  
Mozhgan Shooshtari

The aim of this research was to investigating the effectiveness of psycho-educational interventions on the Rate of attention of preschool children with attention deficit / hyperactivity disorder (ADHD). Statistical population included all Preschool boys with ADHD in Isfahan city, Iran during 2011-2012. The sample of this research was 30 children with ADHD Symptoms. To select this sample, multi-stage random sampling was employed. Then these 30 pre-schoolers were randomly assigned in two groups, (15 children in the experimental group and 15 children in the control group). Research method was experimental with pre and post test design. Research tool, was parent’s Conner’s questionnaire and clinical interview. Psycho-educational interventions as independent variable was performed on experimental group. Data was analyzed by analysis of Covariance. The results showed that the Psycho - Educational interventions is effective on the rate of attention of preschool children with ADHD (p < 0/001). Therefore, psycho-educational intervention is one of appropriate approach for improvement of attention in children with ADHD.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xin-xin Huang ◽  
Ping Ou ◽  
Qin-fang Qian ◽  
Yan Huang

Abstract Background Attention-deficit hyperactivity disorder (ADHD) is the most common behavioral disorder. Behavioural intervention in preschool children with ADHD is considered effective. This study discussed the long-term effectiveness of behavioural intervention in the context of nondrug therapy. Methods The study was a prospective, randomised controlled trial in which 201 preschoolers diagnosed with ADHD who were not receiving any treatment were assigned to two groups from January 2018 to May 2019, 101 were assigned to the conventional group and 100 to the behavioural intervention group. The behavioural intervention group included parental training, behavioural therapy, attention training, relief therapy and game therapy, in addition to the conventional group offerings. Children were evaluated at a baseline, at the end of the 12-month intervention and six months after the intervention. The primary and secondary outcome variables included attention time, the impulse-hyperactivity and hyperactivity index from Conners parent symptom questionnaire (PSQ), full-scale attention quotient (FAQ) and full-scale response control quotient (FRCQ) from integrated visual and auditory comprehensive continuous performance tests. The attention time was observed and recorded by parents, and others were performe(PSQ)d by physicians in the clinic. All statistical analyses were conducted using SPSS V26.0 (IBM), including the descriptive statistics and mixed-effects models and so on. Results The participants’ mean age was (66.17±9.00) months in the behavioural group and (67.54±6.22) months in the conventional group .A total of 190 participants completed a follow-up six months after the intervention. The attention time, Conners parent symptom questionnaire (PSQ), full-scale attention quotient (FAQ) and full-scale response control quotient (FRCQ) increased significantly over time, and the behavioural group improvements were higher than those of conventional group. There was a significant main effect of time (pretest/posttest/follow-up) and group on all outcome measures (t =-12.549-4.069, p<0.05), and a significant interaction of time and group on attention time, impulsivity/hyperactivity, FAQ and FRCQ (t =-3.600-3.313, p<0.05). Conclusion Behavioural intervention can effectively improve behaviour management and relieve symptoms in children with ADHD. These effects lasted at least six months. This study provides a promising approach for improving clinical efficacy with preschool children with ADHD.


2018 ◽  
Vol 43 (5) ◽  
pp. 419-429 ◽  
Author(s):  
Kristie L Sweeney ◽  
Matthew Ryan ◽  
Heather Schneider ◽  
Lisa Ferenc ◽  
Martha Bridge Denckla ◽  
...  

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