NT-PROBNP COMBINED WITH R WAVE IN AVL LEAD PREDICTS MORTALITY BETTER THAN ECHOCARDIOGRAPHIC LEFT VENTRICULAR MASS IN HYPERTENSION

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e233
Author(s):  
P.-Y. Courand ◽  
A. Grandjean ◽  
C. Mouly-Bertin ◽  
M. Serraille ◽  
B. Harbaoui ◽  
...  
Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Gavin R Norton ◽  
Moekanyi J Sibiya ◽  
Elena Libhaber ◽  
Carlos Libhaber ◽  
Hendrik L Booysen ◽  
...  

Whether changes in in-treatment 24-hour aortic blood pressure (BP) predict changes in left ventricular mass (LVM) in response to antihypertensive treatment better than 24-hour brachial BP is uncertain. We imputed 24-hour aortic pulse pressure (PPc) and the 24-hour aortic-to-brachial amplification ratio (PPb/PPc) from an equation that we derived in 1179 participants from a cross-sectional community study. Over a 4-month treatment period in 173 mild-to-moderate hypertensives, 24-hour BP decreased (change in systolic BP/diastolic BP=-22±16/-13±9 mm Hg, p<0.0001), 24-hour PPb/PPc increased (from 1.23±0.08 to 1.27±0.09, p<0.0001) and echocardiographic LVM indexed to height2.7 (LVMI) decreased (-8.8±14.4 g/m2.7, p<0.0001). In-treatment changes in neither 24-hour systolic BP (r=0.08, p=0.32) nor 24-hour PPc (r=0.12, p=0.13) were correlated with changes in LVMI. However, in-treatment increases in the 24-hour PPb/PPc amplification ratio were correlated with decreases in LVMI and these relationships were independent of changes in 24-hour brachial BP and persisted with adjustments for a number of confounders (partial r=-0.24, p<0.005). With or without appropriate adjustments, including baseline LVMI and 24-hour PPb/PPc, marked differences in the change in LVMI (mean±SD in g/m2.7) were noted across tertiles of the change in 24-hour PPb/PPc (Tertiles 1:-4.6±11.1; 2:-8.2±10.2; 3: -11.3±11.0, p<0.05 versus tertiles 1 and 2). With all adjustments including baseline LVMI and 24-hour PPb/PPc, a -6.7 g/m2.7 greater decrease in LVMI was noted in tertile 3 as compared to 1 for change in 24-hour PPb/PPc (p<0.005). In conclusion, the 24-hour aortic-to-brachial PP amplification ratio derived from imputed aortic BP predicts the regression of LVMI in response to antihypertensive treatment better than does 24-hour BP.


2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
P Y Courand ◽  
A Grandjean ◽  
C Mouly-Bertin ◽  
M Serraille ◽  
B Harbaoui ◽  
...  

2006 ◽  
Vol 12 ◽  
pp. 6-7
Author(s):  
Juan Ybarra ◽  
Josep Maria Pou ◽  
Teresa Doñate ◽  
Monica Isart ◽  
Jaime Pujadas

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 284-291 ◽  
Author(s):  
Seong-Woo Choi ◽  
Hye-Yeon Kim ◽  
Hye-Ran Ahn ◽  
Young-Hoon Lee ◽  
Sun-Seog Kweon ◽  
...  

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.


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