scholarly journals WS-04-04: Novel clinical trial design applying Bayesian adaptive randomization for targeted therapy in lung cancer – A step toward personalized medicine

2007 ◽  
Vol 2 (8) ◽  
pp. S291-S292
Author(s):  
J Jack Lee
Keyword(s):  
Lung Cancer ◽  
Clinical Trial ◽  
Targeted Therapy ◽  
Personalized Medicine ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Adaptive Randomization

scholarly journals Promises and challenges of personalized medicine to guide ARDS therapy

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Katherine D. Wick ◽  
Daniel F. McAuley ◽  
Joseph E. Levitt ◽  
Jeremy R. Beitler ◽  
Djillali Annane ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Personalized Medicine ◽  
Trial Design ◽  
Distress Syndrome ◽  
Clinical Trial Design ◽  
First Century ◽  
Global Context ◽  
Patient Level

AbstractIdentifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global context to identify effective ARDS treatments. This review highlights emerging opportunities and continued challenges for personalizing therapy for ARDS, from identifying treatable traits to innovative clinical trial design and recognition of patient-level factors as the field of critical care investigation moves forward into the twenty-first century.

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