Introduction:
SBP is commonly utilized for BP control in stroke, but the clinical significance of DBP in kidney transplant recipients (KTR) is unknown.
Hypothesis:
We hypothesize that DBP at the time of stroke presentation is also associated with risk factor of stroke in KTR.
Methods:
This is a nested case-control study using a closed cohort of end-stage kidney disease patients undergoing kidney transplantation (KT) over a 12-year period. Stroke was diagnosed from brain imaging lesions consistent with localized neurological deficits. One case was matched with three controls based on age and date of KT identified at the same time when the first episode of CVA of each case occurred (incidence density sampling method).
Results:
Of all 752 KTR, 5 stroke cases and 15 controls were identified during the last 2 years of a study period. Mean age±SD was 45±16 VS 47± 12 years. Mean SBP of cases and controls were not significantly different (SBP±SD: 159±24 VS. 135±29 mmHg, p 0.109); whereas, mean DBP of the cases were significantly higher (DBP±SD: 93±7 and 76±13 mmHg; p 0.015) (Figure 1). Compared with the controls, cases’ SBP was 24 mmHg greater, but was not significant; whereas, DBP was 17 mmHg significantly higher (β 24.61; p 0.109; 95%CI -6.07, 55.29) and (β 17; p 0.015; 95%CI 3.69, 30.31). After adjusted by gender, race, body mass index, presence or absence of diabetes, hyperlipidemia, coronary artery disease, and atrial fibrillation, duration after KT, serum calcium and phosphorus, both SBP and DBP were 61 and 28 mmHg significantly higher, respectively among cases compared to the controls (β 61.11; p 0.011; 95%CI 20.31, 101.92) and (β 28.11; p 0.001; 95%CI 16.23, 39.10).
Conclusion:
Although SBP is known to be associated with stroke, DBP at the time of presentation for stroke is also associated with stroke in KTR. Epidemiological studies comparing SBP and DBP for outcomes of stroke in this population will further identify appropriate BP control and may change clinical practice.
MP70-15 CHANGE IN GLOMERULAR VOLUME AND ITS CLINICAL SIGNIFICANCE IN PROTOCOL BIOPSIES AFTER KIDNEY TRANSPLANTATION
