Solitary Splenic Metastasis in a Patient With a Malignant Melanoma Diagnosed With F-18-FDG PET Scanning

2005 ◽  
Vol 30 (8) ◽  
pp. 582-583 ◽  
Author(s):  
Henriette M. E. Quarles van Ufford ◽  
Peter J. C. Zoon ◽  
Paul F. G. M. van Waes ◽  
Gerard van Herk ◽  
John M. H. de Klerk
Keyword(s):  
Malignant Melanoma ◽  
Fdg Pet ◽  
Splenic Metastasis ◽  
Pet Scanning

scholarly journals 18F-5-FPN: A Specific Probe for Monitoring Photothermal Therapy Response in Malignant Melanoma

2020 ◽  
Author(s):  
Yichun Wang ◽  
Mengting Li ◽  
Wenxia Wang ◽  
Hao Ji ◽  
Chaoyi Jia ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Photothermal Therapy ◽  
Therapy Response ◽  
Response Assessment ◽  
Response Evaluation ◽  
Pet Scanning ◽  
Significant Difference ◽  
B16f10 Tumor

Abstract Background The increasing global burden and the significant breakthroughs in malignant melanoma therapy make urgent demands on efficient response evaluation and surveillance of adverse events. Though there have been a few probes explored for early diagnosis or staging of malignant melanoma, but rare for response assessment investigations except for common 18F-deoxyglucose (18F-FDG). Thus, this research would further explore the feasibility and ability of 18F-5-fluoro-N-(2-(diethylamino)ethyl)picolinamide (18F-5-FPN)PET imaging to evaluate photothermal therapy (PTT) response of malignant melanoma, simultaneously comparing with 18F-FDG. Methods B16F10 and MDA-MB-231subcutaneous tumor models were irradiated with an 808 nm laser for PTT. 18F-5-FPN and 18F-FDG PET imaging were adopted to estimate the therapy response. B16F10, inflammatory, and MDA-MB-231 models were subjected to 18F-FDG and 18F-5-FPN PET static acquisitions and compared by quantitative data for assessing the specificity of different agents to different diseases. Furthermore, B16F10 and 231 models were exploited for survival analysis to observe the efficacy and response feature of PTT. Results Melanin in B16F10 tumors successfully transformed the optical energy into heat for PTT. H&E staining at 24 h discovered framework destruction of tumor tissue and extensive necrosis. The mean tumor uptakes of 18F-5-FPN on Day 2 (7.52 ± 3.65%ID/g) and Day 6 (10.22 ± 6.00%ID/g) were much lower than before treatment (p < 0.01). However, no significant difference of the 18F-FDG uptakes was found between Day 1 after PTT and before treatment. 18F-5-FPN PET scanning only manifested B16F10 tumor strikingly, while they all accumulated 18F-FDG highly. PTT contributed to suppressing B16F10 tumors’ growth rapidly in a short time and prolonged the median survival of B16F10 models to some extent. Whereas, both of the temperature and growth of 231 tumors were not distinctly influenced. Conclusions Compared with 18F-FDG PET scanning, 18F-5-FPN PET imaging was capable of estimating PTT efficacy in malignant melanoma, successfully monitored the occult recurrence after therapy, and distinguished malignant melanoma from inflammation and other carcinomas well by high affinity to melanin. This potential probe may provide a new approach for precise and useful response evaluation, timely therapeutic regimen management, and sensitive follow-up.

FDG-PET Scanning Shows Distributed Changes in Cortical Activity Associated with Visual Hallucinations in Eye Disease

2019 ◽  
Vol 19 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Lütfü Hanoglu ◽  
Sultan Yildiz ◽  
Tansel Cakir ◽  
Taha Hanoglu ◽  
Burak Yulug
Keyword(s):  
Visual Cortex ◽  
Fdg Pet ◽  
Underlying Mechanism ◽  
Posterior Cingulate Cortex ◽  
Eye Disease ◽  
Visual Hallucinations ◽  
Charles Bonnet Syndrome ◽  
Pet Scanning ◽  
Inferior Parietal Cortex ◽  
Visual Deafferentation

Background and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the visual hallucinations in CBS patients and pure visually impaired patients is still not clear. </P><P> Methods: In our study, we have scanned three patients with eye disease and CBS (VH+) and three patients with eye disease without CBS (VH-) using FDG-PET. Results: Our results showed underactivity in the pons and overactivity in primary right left visual cortex and inferior parietal cortex in VH- patients and underactivity in left Broca, left inf frontal primary visual cortex and anterior and posterior cingulate cortex in VH+ patients relative to the normative 18FFDG PET data that was taken from the database consisting of 50 age-matched healthy adults without neuropsychiatric disorders. Conclusion: From this distributed pattern of activity changes, we conclude that the generation of visual hallucination in CBS is associated with bottom-up and top-down mechanism rather than the generally accepted visual deafferentation-related hyperexcitability theory.

scholarly journals Tumor response evaluation in patients with malignant melanoma undergoing immune checkpoint inhibitor therapy and prognosis prediction using 18F-FDG PET/CT: multicenter study for comparison of EORTC, PERCIST, and imPERCIST

2021 ◽  
Author(s):  
Kazuhiro Kitajima ◽  
Tadashi Watabe ◽  
Masatoyo Nakajo ◽  
Mana Ishibashi ◽  
Hiromitsu Daisaki ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Malignant Melanoma ◽  
Fdg Pet ◽  
Immune Checkpoint Inhibitor ◽  
Metabolic Response ◽  
Checkpoint Inhibitor ◽  
Response Evaluation ◽  
Pet Ct ◽  
Melanoma Patients ◽  
Fdg Pet Ct

Abstract Objective In malignant melanoma patients treated with immune checkpoint inhibitor (ICI) therapy, three different FDG-PET criteria, European Organization for Research and Treatment of Cancer (EORTC), PET Response Criteria in Solid Tumors (PERCIST), immunotherapy-modified PERCIST (imPERCIST), were compared regarding response evaluation and prognosis prediction using standardized uptake value (SUV) harmonization of results obtained with various PET/CT scanners installed at different centers. Materials and methods Malignant melanoma patients (n = 27) underwent FDG-PET/CT examinations before and again 3 to 9 months after therapy initiation (nivolumab, n = 21; pembrolizumab, n = 6) with different PET scanners at five hospitals. EORTC, PERCIST, and imPERCIST criteria were used to evaluate therapeutic response, then concordance of the results was assessed using Cohen’s κ coefficient. Log-rank and Cox methods were employed to determine progression-free (PFS) and overall (OS) survival. Results Complete metabolic response (CMR)/partial metabolic response (PMR)/stable metabolic disease (SMD)/progressive metabolic disease (PMD) with harmonized EORTC, PERCIST, and imPERCIST was seen in 3/5/4/15, 4/5/3/15, and 4/5/5/13 patients, respectively. Nearly perfect concordance between each pair of criteria was noted (κ = 0.939–0.972). Twenty patients showed progression and 14 died from malignant melanoma after a median 19.2 months. Responders (CMR/PMR) showed significantly longer PFS and OS than non-responders (SMD/PMD) (harmonized EORTC: p < 0.0001 and p = 0.011; harmonized PERCIST: p < 0.0001 and p = 0.0012; harmonized imPERCIST: p < 0.0001 and p = 0.0012, respectively). Conclusions All harmonized FDG-PET criteria (EORTC, PERCIST, imPERCIST) showed accuracy for response evaluation of ICI therapy and prediction of malignant melanoma patient prognosis. Additional studies to determine their value in larger study populations will be necessary.

A Case of Malignant Melanoma With Cardiac and Gallbladder Metastases Detected by FDG PET-CT

2009 ◽  
Vol 34 (12) ◽  
pp. 948-949 ◽  
Author(s):  
Tamer Özülker ◽  
Filiz Özülker ◽  
İrfan Cicin ◽  
Tevfik Özpaçac
Keyword(s):  
Malignant Melanoma ◽  
Fdg Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

Solitary Splenic Metastasis From Hepatocellular Carcinoma Detected on 18F-FDG PET/CT

2015 ◽  
Vol 40 (6) ◽  
pp. e325-e327 ◽  
Author(s):  
Do-Hoon Kim ◽  
Shin Young Jeong ◽  
Sang-Woo Lee ◽  
Jaetae Lee ◽  
Byeong-Cheol Ahn
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fdg Pet ◽  
Splenic Metastasis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

FDG PET scans as evaluation of clinical response to dendritic cell vaccination in patients with malignant melanoma

2012 ◽  
Vol 62 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Lotte Engell-Noerregaard ◽  
Helle W. Hendel ◽  
Helle H. Johannesen ◽  
Louise Alslev ◽  
Inge Marie Svane
Keyword(s):  
Dendritic Cell ◽  
Malignant Melanoma ◽  
Clinical Response ◽  
Fdg Pet ◽  
Dendritic Cell Vaccination ◽  
Pet Scans

18F-FDG PET/CT in the detection of asymptomatic malignant melanoma recurrence

2017 ◽  
Vol 56 (03) ◽  
pp. 83-89 ◽  
Author(s):  
Ismaheel Lawal ◽  
Thabo Lengana ◽  
Kehinde Ololade ◽  
Tebatso Boshomane ◽  
Florette Reyneke ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Diagnostic Accuracy ◽  
Fdg Pet ◽  
Disease Recurrence ◽  
Nodal Metastasis ◽  
Primary Lesion ◽  
Pathologic Features ◽  
Pet Ct ◽  
Fdg Pet Ct

SummaryAim: To evaluate the diagnostic accuracy of FDG PET/CT in the detection of asymptomatic recurrence in patients with malignant melanoma who have had resection of their primary lesion. We also aimed to determine the pattern and factors predisposing to disease recurrence. Methods: Patients with malignant melanoma who have had surgical resection of their disease and without any clinical evidence of disease recurrence were followed- up with FDG PET/CT. The diagnostic accuracy of FDG PET/CT, pattern of recurrence and factors predictive of disease recurrence were determined. Results: A total of 144 patients were followed-up for a median period of 50.50 months. Asymptomatic recurrence was seen in 37 patients (25.7 %) with a median time to recurrence of 20 months. Lymph node was the commonest site of asymptomatic recurrence. Sex, tumour depth, histology type and presence of nodal metastasis were significant predictors of tumour recurrence. Age, race, site of primary lesion, type of lymph node resection were not significant predictors of disease recurrence. Race has a significant effect on the histological subtype of tumour (nodular maligna was more common in Caucasian while acral lentiginous was more prevalent in the Blacks) and the site of the primary lesion (lower limb in Blacks and trunk in Caucasians). Sensitivity, specificity and accuracy of FDG PET/CT for the detection of disease recurrence were 94.5 %, 87.6 % and 89.6 % respectively. Conclusion: FDG PET/CT is a suitable modality for early detection of asymptomatic recurrence of malignant melanoma. Asymptomatic recurrence most commonly occurs in lymph nodes. Sex, nodal metastasis and tumour pathologic features are predictors of recurrence.

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